CaMPDB :: Substrate

XSB1881 : PREDICTED: neurotensin/neuromedin N isoform 3 [Pan troglodytes]

This entry is computationally expanded from SB0034

* Basic Information

Organism	Pan troglodytes (chimpanzee)
Protein Names	neurotensin/neuromedin N isoform 3
Gene Names	NTS; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 5 mRNAs, 214 ESTs, 1 Protein
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
XP_001165130	XM_001165130	745818	N/A	N/A	N/A	N/A	N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 170 aa

Average Mass: 19.885 kDa

Monoisotopic Mass: 19.872 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Pro-NT_NN 1.	2	170	468.2	1.2e-137
--- cleavage 153 (inside Pro-NT_NN 2..170) ---
--- cleavage 158 (inside Pro-NT_NN 2..170) ---

3. Sequence Information

Fasta Sequence: XSB1881.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] IPYILKRQLY¹⁵³-ENKPRRPYIL

Tyr¹⁵³ Glu

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Ile¹⁴⁴	Pro¹⁴⁵	Tyr¹⁴⁶	Ile¹⁴⁷	Leu¹⁴⁸	Lys¹⁴⁹	Arg¹⁵⁰	Gln¹⁵¹	Leu¹⁵²	Tyr¹⁵³

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Glu¹⁵⁴	Asn¹⁵⁵	Lys¹⁵⁶	Pro¹⁵⁷	Arg¹⁵⁸	Arg¹⁵⁹	Pro¹⁶⁰	Tyr¹⁶¹	Ile¹⁶²	Leu¹⁶³

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
EDILDTGNDKNEKEEVIKRKIPYILKRQLYENKPRRPYILKRDSYYY

Summary

#	organism	max score	hits	top seq
1	Pan troglodytes	100.00	3	PREDICTED: neurotensin/neuromedin N isoform 3
2	Macaca fascicularis	100.00	1	hypothetical protein
3	Macaca mulatta	100.00	1	PREDICTED: neurotensin
4	Homo sapiens	98.20	3	neurotensin/neuromedin N preproprotein
5	Contains: Large neuromedin N (NmN-125); Neuromedin N (NmN) (NN); Neurotensin (NT); Tail peptide	96.30	2	NEUT_BOVIN Neurotensin/neuromedin N precursor
6	Bos taurus	96.30	1	neurotensin
7	Canis familiaris	95.90	1	PREDICTED: similar to Neurotensin/neuromedin N pre
8	Mus musculus	92.80	1	neurotensin
9	Rattus norvegicus	91.30	1	PREDICTED: similar to Neurotensin/neuromedin N pre
10	N/A	91.30	1	-
11	Monodelphis domestica	72.80	1	PREDICTED: similar to Neurotensin/neuromedin N pre
12	Xenopus laevis	62.00	1	MGC84018 protein
13	Gallus gallus	60.80	1	PREDICTED: similar to Neurotensin/neuromedin N pre

Top-ranked sequences

organism	matching
Pan troglodytes	Query 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170
Macaca fascicularis	Query 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170
Macaca mulatta	Query 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170
Homo sapiens	Query 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170 \|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 124 EDILDTGNDKNGKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170
Contains: Large neuromedin N (NmN-125); Neuromedin N (NmN) (NN); Neurotensin (NT); Tail peptide	Query 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170 \|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\| Sbjct 123 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
Bos taurus	Query 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170 \|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\| Sbjct 124 EDILDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 170
Canis familiaris	Query 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170 \|\|+\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\| Sbjct 124 EDVLDAGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 170
Mus musculus	Query 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170 \|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\| Sbjct 123 EDILDNVNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRGSYYY 169
Rattus norvegicus	Query 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170 \|\|\|\|\| \|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\| Sbjct 123 EDILDHGNEKTEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRASYYY 169
N/A	Query 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170 \|\|\|\|\| \|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\| Sbjct 79 EDILDHGNEKTEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRASYYY 125
Monodelphis domestica	Query 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYYY 170 +\|\|\|+\|\|\| \|\|\|\|\|+\|\|\| \|\|\|\|\|\|\|++# \|\| \|\|\|\|\|\|\|\| \| \|\| Sbjct 119 DDILETGNLNREKEEVMKRKTPYILKRQIH#VNKARRPYILKRSSSYY 165
Xenopus laevis	Query 125 DILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYY 169 \| \|+ + +\|\|+\| \|\|\|\| \|\|\|\|\|\|\| \|# +\| \|\|\|\|\|\|\|\| \|\|\| Sbjct 122 DYLEPNSPNSEKDEPIKRKTPYILKRQTY#VSKARRPYILKRGSYY 166
Gallus gallus	Query 124 EDILDTGNDKNEKEEVIKRKIPYILKRQLY#ENKPRRPYILKRDSYY 169 +\| \| \| \|\|\| ++\|\|\| \|\|\|\|\|\|\|\|+# \|\| \|\|\|\|\|\|\|\| \|\|\| Sbjct 120 QDAFDLENSSQEKE-IMKRKNPYILKRQLH#VNKARRPYILKRSSYY 164

[Site 2] KRQLYENKPR¹⁵⁸-RPYILKRDSY

Arg¹⁵⁸ Arg

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Lys¹⁴⁹	Arg¹⁵⁰	Gln¹⁵¹	Leu¹⁵²	Tyr¹⁵³	Glu¹⁵⁴	Asn¹⁵⁵	Lys¹⁵⁶	Pro¹⁵⁷	Arg¹⁵⁸

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Arg¹⁵⁹	Pro¹⁶⁰	Tyr¹⁶¹	Ile¹⁶²	Leu¹⁶³	Lys¹⁶⁴	Arg¹⁶⁵	Asp¹⁶⁶	Ser¹⁶⁷	Tyr¹⁶⁸

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
TGNDKNEKEEVIKRKIPYILKRQLYENKPRRPYILKRDSYYY

Summary

#	organism	max score	hits	top seq
1	Pan troglodytes	91.30	3	PREDICTED: neurotensin/neuromedin N isoform 3
2	Macaca fascicularis	91.30	1	hypothetical protein
3	Macaca mulatta	91.30	1	PREDICTED: neurotensin
4	Homo sapiens	88.60	3	neurotensin/neuromedin N preproprotein
5	Contains: Large neuromedin N (NmN-125); Neuromedin N (NmN) (NN); Neurotensin (NT); Tail peptide	86.70	2	NEUT_BOVIN Neurotensin/neuromedin N precursor
6	Bos taurus	86.70	1	neurotensin
7	Canis familiaris	86.70	1	PREDICTED: similar to Neurotensin/neuromedin N pre
8	Mus musculus	84.30	1	neurotensin
9	Rattus norvegicus	82.40	1	PREDICTED: similar to Neurotensin/neuromedin N pre
10	N/A	82.40	1	-
11	Monodelphis domestica	65.90	1	PREDICTED: similar to Neurotensin/neuromedin N pre
12	Xenopus laevis	58.20	1	MGC84018 protein
13	Gallus gallus	57.80	1	PREDICTED: similar to Neurotensin/neuromedin N pre

Top-ranked sequences

organism	matching
Pan troglodytes	Query 129 TGNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\| Query 129 TGNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170
Macaca fascicularis	Query 129 TGNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\| Query 129 TGNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170
Macaca mulatta	Query 129 TGNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\| Query 129 TGNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170
Homo sapiens	Query 129 TGNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170 \|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 129 TGNDKNGKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170
Contains: Large neuromedin N (NmN-125); Neuromedin N (NmN) (NN); Neurotensin (NT); Tail peptide	Query 130 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\| Sbjct 129 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
Bos taurus	Query 130 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\| Sbjct 130 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 170
Canis familiaris	Query 130 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\| Sbjct 130 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 170
Mus musculus	Query 131 NDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\| Sbjct 130 NDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRGSYYY 169
Rattus norvegicus	Query 130 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170 \|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\| Sbjct 129 GNEKTEKEEVIKRKIPYILKRQLYENKPR#RPYILKRASYYY 169
N/A	Query 130 GNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170 \|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| \|\|\|\| Sbjct 85 GNEKTEKEEVIKRKIPYILKRQLYENKPR#RPYILKRASYYY 125
Monodelphis domestica	Query 129 TGNDKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYYY 170 \|\|\| \|\|\|\|\|+\|\|\| \|\|\|\|\|\|\|++ \|\| \|#\|\|\|\|\|\|\| \| \|\| Sbjct 124 TGNLNREKEEVMKRKTPYILKRQIHVNKAR#RPYILKRSSSYY 165
Xenopus laevis	Query 134 NEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYY 169 +\|\|+\| \|\|\|\| \|\|\|\|\|\|\| \| +\| \|#\|\|\|\|\|\|\| \|\|\| Sbjct 131 SEKDEPIKRKTPYILKRQTYVSKAR#RPYILKRGSYY 166
Gallus gallus	Query 132 DKNEKEEVIKRKIPYILKRQLYENKPR#RPYILKRDSYY 169 + ++++\|++\|\|\| \|\|\|\|\|\|\|\|+ \|\| \|#\|\|\|\|\|\|\| \|\|\| Sbjct 127 NSSQEKEIMKRKNPYILKRQLHVNKAR#RPYILKRSSYY 164

* References

None.