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XSB1890 : calpain, small subunit 1 [Rattus norvegicus]

[ CaMP Format ]

This entry is computationally expanded from SB0017

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein NamesCalpain small subunit 1; CSS1; Calcium-dependent protease small subunit 1; Calcium-dependent protease small subunit; CDPS; Calpain regulatory subunit; Calcium-activated neutral proteinase small subunit; CANP small subunit; calpain; small subunit 1; calpain 4
Gene NamesCapns1; Capn4, Css1; Capn4; Css1; calpain, small subunit 1
Gene Locus1q21; chromosome 1
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_058814 NM_017118 29156 Q64537 N/A N/A N/A rno:29156

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 270 aa

Average Mass: 28.570 kDa

Monoisotopic Mass: 28.552 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
TAT_signal 1. 6262.48.7
--- cleavage 143 ---
efhand 1. 14517318.40.03
efhand 2. 17520315.90.17
efhand 3. 2402677.53.2

3. Sequence Information

Fasta Sequence: XSB1890.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1AJ5 (X-ray; 230 A; A/B=98-270), 1DF0 (X-ray; 260 A; B=88-270), 1DVI (X-ray; 230 A; A/B=88-270), 1NP8 (X-ray; 200 A; A/B=91-249), 1U5I (X-ray; 286 A; B=88-270), 3BOW (X-ray; 240 A; B=88-270), 3DF0 (X-ray; 295 A; B=88-270)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] PDLKTDGFGI143-DTCRSMVAVM

Ile143 Asp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro134Asp135Leu136Lys137Thr138Asp139Gly140Phe141Gly142Ile143
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asp144Thr145Cys146Arg147Ser148Met149Val150Ala151Val152Met153

Sequence conservation (by blast)

* References

[PubMed ID: 18544539] Niapour M, Yu Y, Berger SA, Regulation of calpain activity by c-Myc through calpastatin and promotion of transformation in c-Myc-negative cells by calpastatin suppression. J Biol Chem. 2008 Aug 1;283(31):21371-81. Epub 2008 Jun 10.

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