logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB1892 : Chain A, Inhibitor And Calcium Bound Domain Vi Of Porcine Calpain

[ CaMP Format ]

This entry is computationally expanded from SB0017

* Basic Information

OrganismSus scrofa (pig)
Protein NamesCalpain small subunit 1; CSS1; Calcium-dependent protease small subunit 1; Calcium-dependent protease small subunit; CDPS; Calpain regulatory subunit; Calcium-activated neutral proteinase small subunit; CANP small subunit
Gene NamesCAPN4
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
1ALW_A N/A N/A P04574 N/A N/A N/A ssc:397587

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 173 aa

Average Mass: 19.861 kDa

Monoisotopic Mass: 19.849 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 46 ---
efhand 1. 487618.40.03
efhand 2. 7810616.50.11
efhand 3. 1431708.22.7

3. Sequence Information

Fasta Sequence: XSB1892.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1ALV (X-ray; 190 A; A/B=94-266), 1ALW (X-ray; 203 A; A/B=94-266), 1NX0 (X-ray; 230 A; A/B=94-266), 1NX1 (X-ray; 200 A; A/B=94-266), 1NX2 (X-ray; 220 A; A=94-266), 1NX3 (X-ray; 245 A; A=94-266)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] PDLKTDGFGI46-DTCRSMVAVM

Ile46 Asp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro37Asp38Leu39Lys40Thr41Asp42Gly43Phe44Gly45Ile46
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asp47Thr48Cys49Arg50Ser51Met52Val53Ala54Val55Met56

Sequence conservation (by blast)

* References

[PubMed ID: 9228946] Lin GD, Chattopadhyay D, Maki M, Wang KK, Carson M, Jin L, Yuen PW, Takano E, Hatanaka M, DeLucas LJ, Narayana SV, Crystal structure of calcium bound domain VI of calpain at 1.9 A resolution and its role in enzyme assembly, regulation, and inhibitor binding. Nat Struct Biol. 1997 Jul;4(7):539-47.