logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB1893 : calpain, small subunit 1 [Bos taurus]

[ CaMP Format ]

This entry is computationally expanded from SB0017

* Basic Information

OrganismBos taurus (cattle)
Protein NamesCalpain small subunit 1; CSS1; Calcium-dependent protease small subunit 1; Calcium-dependent protease small subunit; CDPS; Calpain regulatory subunit; Calcium-activated neutral proteinase small subunit; CANP small subunit; calpain; small subunit 1; calpain 4; small subunit (30K)
Gene NamesCAPNS1; CAPN4; calpain, small subunit 1
Gene Locus18; chromosome 18
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_776686 NM_174261 281664 P13135 N/A N/A N/A bta:281664

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 263 aa

Average Mass: 27.931 kDa

Monoisotopic Mass: 27.914 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
TAT_signal 1. 6262.48.7
MazG 1. 79130-27.13.4
--- cleavage 136 ---
efhand 1. 13816618.40.03
efhand 2. 16819615.50.22
efhand 3. 2332608.22.7

3. Sequence Information

Fasta Sequence: XSB1893.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] PDLKTDGFGI136-DTCRSMVAVM

Ile136 Asp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro127Asp128Leu129Lys130Thr131Asp132Gly133Phe134Gly135Ile136
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asp137Thr138Cys139Arg140Ser141Met142Val143Ala144Val145Met146

Sequence conservation (by blast)

* References

[PubMed ID: 2551902] McCelland P, Lash JA, Hathaway DR, Identification of major autolytic cleavage sites in the regulatory subunit of vascular calpain II. A comparison of partial amino-terminal sequences to deduced sequence from complementary DNA. J Biol Chem. 1989 Oct 15;264(29):17428-31.