logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB1896 : Chain A, Calpain Domain Vi With Calcium Bound

[ CaMP Format ]

This entry is computationally expanded from SB0017

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein NamesCalpain small subunit 1; CSS1; Calcium-dependent protease small subunit 1; Calcium-dependent protease small subunit; CDPS; Calpain regulatory subunit; Calcium-activated neutral proteinase small subunit; CANP small subunit
Gene NamesCapn4, Css1; Capn4; Css1
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
1DVI_A N/A N/A Q64537 N/A N/A N/A rno:29156

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 184 aa

Average Mass: 21.265 kDa

Monoisotopic Mass: 21.251 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 57 ---
efhand 1. 598715.20.27
efhand 2. 8911715.90.17
efhand 3. 1541817.53.2

3. Sequence Information

Fasta Sequence: XSB1896.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1AJ5 (X-ray; 230 A; A/B=98-270), 1DF0 (X-ray; 260 A; B=88-270), 1DVI (X-ray; 230 A; A/B=88-270), 1NP8 (X-ray; 200 A; A/B=91-249), 1U5I (X-ray; 286 A; B=88-270), 3BOW (X-ray; 240 A; B=88-270), 3DF0 (X-ray; 295 A; B=88-270)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] PDLKTDGFGI57-DTSRSMVAVM

Ile57 Asp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro48Asp49Leu50Lys51Thr52Asp53Gly54Phe55Gly56Ile57
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asp58Thr59Ser60Arg61Ser62Met63Val64Ala65Val66Met67

Sequence conservation (by blast)

* References

[PubMed ID: 7982961] Graham-Siegenthaler K, Gauthier S, Davies PL, Elce JS, Active recombinant rat calpain II. Bacterially produced large and small subunits associate both in vivo and in vitro. J Biol Chem. 1994 Dec 2;269(48):30457-60.

» More (2)