XSB1907 : protein tyrosine phosphatase, receptor type, N [Bos taurus]
[ CaMP Format ]
This entry is computationally expanded from SB0024
* Basic Information
| Organism | Bos taurus (cattle) |
| Protein Names | Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell autoantigen 512; ICA512; protein tyrosine phosphatase; receptor type; N |
| Gene Names | PTPRN; protein tyrosine phosphatase, receptor type, N |
| Gene Locus | 2; chromosome 2 |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 979 aa
Average Mass: 105.908 kDa
Monoisotopic Mass: 105.842 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| Toxin_19 1. | 39 | 71 | -7.6 | 4.4 |
| FDX-ACB 1. | 474 | 550 | -51.5 | 1.7 |
| --- cleavage 658 --- |
| Y_phosphatase 1. | 734 | 968 | 386.2 | 5.8e-113 |
3. Sequence Information
Fasta Sequence: XSB1907.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] PEPSRVSSVS658-SQFSDAAQAS
Ser658 
Ser
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Pro649 | Glu650 | Pro651 | Ser652 | Arg653 | Val654 | Ser655 | Ser656 | Val657 | Ser658 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Ser659 | Gln660 | Phe661 | Ser662 | Asp663 | Ala664 | Ala665 | Gln666 | Ala667 | Ser668 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
QDLCRQHMATKSLFNRAEGPPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMD
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Homo sapiens |
66.20 |
5 |
protein tyrosine phosphatase, receptor type, N pre |
| 2 |
N/A |
66.20 |
4 |
I |
| 3 |
Bos taurus |
66.20 |
1 |
protein tyrosine phosphatase, receptor type, N |
| 4 |
Pongo pygmaeus |
66.20 |
1 |
hypothetical protein |
| 5 |
Pan troglodytes |
66.20 |
1 |
PREDICTED: protein tyrosine phosphatase, receptor |
| 6 |
synthetic construct |
66.20 |
1 |
Homo sapiens protein tyrosine phosphatase, recepto |
| 7 |
Mus musculus |
63.20 |
9 |
protein tyrosine phosphatase, receptor type, N |
| 8 |
Rattus norvegicus |
63.20 |
2 |
protein tyrosine phosphatase, receptor type, N |
| 9 |
Rattus sp. |
63.20 |
1 |
BAA07397.1 |
| 10 |
Canis familiaris |
62.40 |
2 |
PREDICTED: similar to Receptor-type tyrosine-prote |
Top-ranked sequences
| organism | matching |
|---|
| Homo sapiens |
Query 629 QDLCRQHMATKSLFNRAEGPPEXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 688
|||||||||||||||||||||| # |||||||||||
Sbjct 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688
|
| N/A |
Query 629 QDLCRQHMATKSLFNRAEGPPEXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 688
|||||||||||||||||||||| # |||||||||||
Sbjct 241 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 300
|
| Bos taurus |
Query 629 QDLCRQHMATKSLFNRAEGPPEXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 688
|||||||||||||||||||||| # |||||||||||
Sbjct 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688
|
| Pongo pygmaeus |
Query 629 QDLCRQHMATKSLFNRAEGPPEXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 688
|||||||||||||||||||||| # |||||||||||
Sbjct 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688
|
| Pan troglodytes |
Query 629 QDLCRQHMATKSLFNRAEGPPEXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 688
|||||||||||||||||||||| # |||||||||||
Sbjct 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688
|
| synthetic construct |
Query 629 QDLCRQHMATKSLFNRAEGPPEXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 688
|||||||||||||||||||||| # |||||||||||
Sbjct 241 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 300
|
| Mus musculus |
Query 629 QDLCRQHMATKSLFNRAEGPPEXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 688
||||||||||||||||||| || # |||||||||||
Sbjct 631 QDLCRQHMATKSLFNRAEGQPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 690
|
| Rattus norvegicus |
Query 629 QDLCRQHMATKSLFNRAEGPPEXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 688
||||||||||||||||||| || # |||||||||||
Sbjct 633 QDLCRQHMATKSLFNRAEGQPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 692
|
| Rattus sp. |
Query 629 QDLCRQHMATKSLFNRAEGPPEXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 688
||||||||||||||||||| || # |||||||||||
Sbjct 572 QDLCRQHMATKSLFNRAEGQPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 631
|
| Canis familiaris |
Query 629 QDLCRQHMATKSLFNRAEGPPEXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 688
||||||||| ||||+||||||| # |||||||||||
Sbjct 726 QDLCRQHMAAKSLFSRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 785
|
* References
[PubMed ID: 10457160] Hermel JM, Dirkx R Jr, Solimena M, Post-translational modifications of ICA512, a receptor tyrosine phosphatase-like protein of secretory granules. Eur J Neurosci. 1999 Aug;11(8):2609-20.
