CaMPDB :: Substrate

XSB1908 : protein tyrosine phosphatase, receptor type, N [Mus musculus]

This entry is computationally expanded from SB0024

* Basic Information

Organism	Mus musculus (house mouse)
Protein Names	Protein tyrosine phosphatase, receptor type, N; protein tyrosine phosphatase; receptor type; N; receptor-type
Gene Names	Ptprn; protein tyrosine phosphatase, receptor type, N
Gene Locus	1 41.0 cM; chromosome 1
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_033011	NM_008985	19275	Q6NVE2	N/A	N/A	N/A	mmu:19275

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 981 aa

Average Mass: 106.025 kDa

Monoisotopic Mass: 105.959 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Toxin_19 1.	42	74	-6.3	2.9
TrmB 1.	350	406	-30.4	4.9
FDX-ACB 1.	476	552	-53.8	2.9
FCD 1.	585	707	-29.2	7.7
--- cleavage 660 (inside FCD 585..707) ---
Y_phosphatase 1.	736	970	386.1	6e-113

3. Sequence Information

Fasta Sequence: XSB1908.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] PEPSRVSSVS⁶⁶⁰-SQFSDAAQAS

Ser⁶⁶⁰ Ser

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Pro⁶⁵¹	Glu⁶⁵²	Pro⁶⁵³	Ser⁶⁵⁴	Arg⁶⁵⁵	Val⁶⁵⁶	Ser⁶⁵⁷	Ser⁶⁵⁸	Val⁶⁵⁹	Ser⁶⁶⁰

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ser⁶⁶¹	Gln⁶⁶²	Phe⁶⁶³	Ser⁶⁶⁴	Asp⁶⁶⁵	Ala⁶⁶⁶	Ala⁶⁶⁷	Gln⁶⁶⁸	Ala⁶⁶⁹	Ser⁶⁷⁰

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
QDLCRQHMATKSLFNRAEGQPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMD

Summary

#	organism	max score	hits	top seq
1	Mus musculus	57.80	9	protein tyrosine phosphatase, receptor type, N
2	Homo sapiens	57.80	5	protein tyrosine phosphatase, receptor type, N pre
3	N/A	57.80	4	P
4	Rattus norvegicus	57.80	2	protein tyrosine phosphatase, receptor type, N
5	Pan troglodytes	57.80	1	PREDICTED: protein tyrosine phosphatase, receptor
6	Bos taurus	57.80	1	protein tyrosine phosphatase, receptor type, N
7	Pongo pygmaeus	57.80	1	hypothetical protein
8	synthetic construct	57.80	1	Homo sapiens protein tyrosine phosphatase, recepto
9	Rattus sp.	57.80	1	BAA07397.1
10	Canis familiaris	53.90	2	PREDICTED: similar to Receptor-type tyrosine-prote

Top-ranked sequences

organism	matching
Mus musculus	Query 631 QDLCRQHMATKSLFNRAEGXXXXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 690 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\| Sbjct 631 QDLCRQHMATKSLFNRAEGQPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 690
Homo sapiens	Query 631 QDLCRQHMATKSLFNRAEGXXXXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 690 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\| Sbjct 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688
N/A	Query 631 QDLCRQHMATKSLFNRAEGXXXXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 690 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\| Sbjct 629 QDLCRQHMATKSLFNRAEGQPEPSRVSSVS#SQFSDAAQASPSSHSSSPSWCEEPAQANMD 688
Rattus norvegicus	Query 631 QDLCRQHMATKSLFNRAEGXXXXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 690 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\| Sbjct 633 QDLCRQHMATKSLFNRAEGQPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 692
Pan troglodytes	Query 631 QDLCRQHMATKSLFNRAEGXXXXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 690 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\| Sbjct 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688
Bos taurus	Query 631 QDLCRQHMATKSLFNRAEGXXXXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 690 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\| Sbjct 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688
Pongo pygmaeus	Query 631 QDLCRQHMATKSLFNRAEGXXXXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 690 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\| Sbjct 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688
synthetic construct	Query 631 QDLCRQHMATKSLFNRAEGXXXXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 690 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\| Sbjct 241 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 300
Rattus sp.	Query 631 QDLCRQHMATKSLFNRAEGXXXXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 690 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\| Sbjct 572 QDLCRQHMATKSLFNRAEGQPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 631
Canis familiaris	Query 631 QDLCRQHMATKSLFNRAEGXXXXXXXXXXX#XXXXXXXXXXXXXXXXXXXWCEEPAQANMD 690 \|\|\|\|\|\|\|\|\| \|\|\|\|+\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\| Sbjct 726 QDLCRQHMAAKSLFSRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 785

* References

[PubMed ID: 19361477] Nishimura T, Kobosaki A, Ito Y, Notkins AL, Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan. Neuroscience. 2009 Mar 17;159(2):427-37.

» More (9) « Hide Below

[PubMed ID: 19019914] ... Kim SM, Theilig F, Qin Y, Cai T, Mizel D, Faulhaber-Walter R, Hirai H, Bachmann S, Briggs JP, Notkins AL, Schnermann J, Dense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathway. Am J Physiol Renal Physiol. 2009 Feb;296(2):F382-9. Epub 2008 Nov 19.

[PubMed ID: 18824546] ... Trajkovski M, Mziaut H, Schubert S, Kalaidzidis Y, Altkruger A, Solimena M, Regulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512. J Biol Chem. 2008 Nov 28;283(48):33719-29. Epub 2008 Sep 29.

[PubMed ID: 18310453] ... Henquin JC, Nenquin M, Szollosi A, Kubosaki A, Louis Notkins A, Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta. J Endocrinol. 2008 Mar;196(3):573-81.

[PubMed ID: 18178618] ... Mziaut H, Kersting S, Knoch KP, Fan WH, Trajkovski M, Erdmann K, Bergert H, Ehehalt F, Saeger HD, Solimena M, ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):674-9. Epub 2008 Jan 4.

[PubMed ID: 9383296] ... Leiter EH, Tsumura H, Serreze DV, Chapman HD, Rabin DU, Lan MS, Notkins AL, Mapping to chromosomes 1 and 12 of mouse homologs of human protein tyrosine phosphatase, receptor-type, related genes encoding pancreatic beta cell autoantigens. Mamm Genome. 1997 Dec;8(12):949-50.

[PubMed ID: 8933284] ... Notkins AL, Lu J, Li Q, VanderVegt FP, Wasserfall C, Maclaren NK, Lan MS, IA-2 and IA-2 beta are major autoantigens in IDDM and the precursors of the 40 kDa and 37 kDa tryptic fragments. J Autoimmun. 1996 Oct;9(5):677-82.

[PubMed ID: 8526904] ... Magistrelli G, Covini N, Mosca M, Lippoli G, Isacchi A, Expression of PTP35, the murine homologue of the protein tyrosine phosphatase-related sequence IA-2, is regulated during cell growth and stimulated by mitogens in 3T3 fibroblasts. Biochem Biophys Res Commun. 1995 Dec 5;217(1):154-61.

[PubMed ID: 7832766] ... Hendriks W, Schepens J, Brugman C, Zeeuwen P, Wieringa B, A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain. Biochem J. 1995 Jan 15;305 ( Pt 2):499-504.

[PubMed ID: 7980563] ... Lu J, Notkins AL, Lan MS, Isolation, sequence and expression of a novel mouse brain cDNA, mIA-2, and its relatedness to members of the protein tyrosine phosphatase family. Biochem Biophys Res Commun. 1994 Oct 28;204(2):930-6.