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XSB1917 : tyrosine phosphatase-like protein IA-2a

[ CaMP Format ]

This entry is computationally expanded from SB0024

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein NamesReceptor-type tyrosine-protein phosphatase-like N; R-PTP-N; 105 kDa islet cell antigen; ICA105; PTP IA-2; PTPLP; Brain-enriched membrane-associated protein tyrosine phosphatase; BEM-3
Gene NamesPtprn
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAA83235 N/A N/A Q63259 N/A N/A N/A rno:116660

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 971 aa

Average Mass: 105.159 kDa

Monoisotopic Mass: 105.094 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Toxin_19 1. 3365-6.32.9
DUF1008 1. 272355-101.58.6
CbtB 1. 557595-31.17.1
--- cleavage 650 ---
Y_phosphatase 1. 726960334.71.8e-97

3. Sequence Information

Fasta Sequence: XSB1917.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] PEPSRVSSVS650-SKFSDAAQAN

Ser650 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro641Glu642Pro643Ser644Arg645Val646Ser647Ser648Val649Ser650
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser651Lys652Phe653Ser654Asp655Ala656Ala657Gln658Ala659Asn660

Sequence conservation (by blast)

* References

[PubMed ID: 7657822] Payton MA, Hawkes CJ, Christie MR, Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J Clin Invest. 1995 Sep;96(3):1506-11.