XSB1922 : Receptor-type tyrosine-protein phosphatase-like N
[ CaMP Format ]
This entry is computationally expanded from SB0024
* Basic Information
| Organism | Rattus norvegicus (Norway rat) |
| Protein Names | R-PTP-N; 105 kDa islet cell antigen; ICA105; PTP IA-2; PTPLP; Brain-enriched membrane-associated protein tyrosine phosphatase; BEM-3 |
| Gene Names | Ptprn |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| Q63259 | N/A | N/A | Q63259 | N/A | N/A | N/A | rno:116660 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 983 aa
Average Mass: 106.228 kDa
Monoisotopic Mass: 106.161 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Toxin_19 1. | 45 | 77 | -6.3 | 2.9 |
| DUF1008 1. | 284 | 367 | -101.5 | 8.6 |
| FDX-ACB 1. | 478 | 554 | -52.3 | 2 |
| FCD 1. | 587 | 709 | -29.0 | 7.4 |
| --- cleavage 662 (inside FCD 587..709) --- | ||||
| Y_phosphatase 1. | 738 | 972 | 386.2 | 5.8e-113 |
3. Sequence Information
Fasta Sequence: XSB1922.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] PEPSRVSSVS662-SQFSDAAQAS
Ser662 
Ser
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Pro653 | Glu654 | Pro655 | Ser656 | Arg657 | Val658 | Ser659 | Ser660 | Val661 | Ser662 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser663 | Gln664 | Phe665 | Ser666 | Asp667 | Ala668 | Ala669 | Gln670 | Ala671 | Ser672 |
Sequence conservation (by blast)
* References
[PubMed ID: 7568143] Passini N, Larigan JD, Genovese S, Appella E, Sinigaglia F, Rogge L, The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9412-6.