XSB1934 : dystrophin [Canis lupus familiaris]
[ CaMP Format ]
This entry is computationally expanded from SB0073
* Basic Information
| Organism | Canis lupus familiaris (dog) |
| Protein Names | dystrophin |
| Gene Names | DMD; dystrophin (muscular dystrophy, Duchenne and Becker types) |
| Gene Locus | X; chromosome X |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_001003343 | NM_001003343 | 606758 | O97592 | N/A | N/A | N/A | cfa:606758 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 3680 aa
Average Mass: 425.653 kDa
Monoisotopic Mass: 425.389 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| CH 1. | 16 | 119 | 111.2 | 3.6e-30 |
| CH 2. | 135 | 240 | 102.4 | 1.6e-27 |
| Spectrin 1. | 340 | 448 | 71.6 | 2.9e-18 |
| Spectrin 2. | 449 | 557 | 65.2 | 2.4e-16 |
| Spectrin 3. | 560 | 668 | 2.2 | 0.022 |
| --- cleavage 691 --- | ||||
| Spectrin 4. | 720 | 828 | 12.3 | 0.0031 |
| Spectrin 5. | 831 | 935 | 30.6 | 6.3e-06 |
| Spectrin 6. | 944 | 1047 | 14.4 | 0.0021 |
| Spectrin 7. | 1050 | 1156 | 83.4 | 8e-22 |
| Spectrin 8. | 1159 | 1265 | 55.4 | 2.2e-13 |
| Spectrin 9. | 1268 | 1369 | 18.6 | 0.00092 |
| Involucrin_N 1. | 1370 | 1437 | -12.9 | 9.6 |
| Spectrin 10. | 1461 | 1570 | 0.4 | 0.031 |
| Spectrin 11. | 1573 | 1678 | 52.2 | 1.9e-12 |
| Spectrin 12. | 1681 | 1781 | 59.2 | 1.5e-14 |
| Involucrin 1. | 1851 | 1860 | 2.3 | 1.3e |
| Spectrin 13. | 1879 | 1981 | 47.7 | 4.6e-11 |
| Osmo_CC 1. | 2011 | 2055 | 2.9 | 6.1 |
| Spectrin 14. | 2106 | 2210 | 79.8 | 1e-20 |
| Spectrin 15. | 2213 | 2320 | 59.5 | 1.3e-14 |
| Involucrin 2. | 2325 | 2334 | 3.0 | 89 |
| Spectrin 16. | 2465 | 2572 | 15.2 | 0.0018 |
| Spectrin 17. | 2575 | 2681 | 50.1 | 8.6e-12 |
| Spectrin 18. | 2684 | 2797 | 25.4 | 0.00024 |
| Spectrin 19. | 2800 | 2926 | 3.7 | 0.017 |
| Spectrin 20. | 2929 | 3035 | 71.5 | 3.1e-18 |
| WW 1. | 3052 | 3081 | 48.9 | 2e-11 |
| efhand_1 1. | 3082 | 3202 | 275.0 | 1.6e-79 |
| efhand_2 1. | 3206 | 3297 | 230.0 | 6.1e-66 |
| ZZ 1. | 3302 | 3347 | 93.3 | 8.6e-25 |
| M 1. | 3496 | 3516 | 0.9 | 1.1e |
| M 2. | 3562 | 3582 | 5.1 | 31 |
| Involucrin 3. | 3651 | 3660 | 2.1 | 1.5e |
3. Sequence Information
Fasta Sequence: XSB1934.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] VMETVTMVTT691-REHILVKHAQ
Thr691 
Arg
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val682 | Met683 | Glu684 | Thr685 | Val686 | Thr687 | Met688 | Val689 | Thr690 | Thr691 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Arg692 | Glu693 | His694 | Ile695 | Leu696 | Val697 | Lys698 | His699 | Ala700 | Gln701 |
Sequence conservation (by blast)
* References
[PubMed ID: 18458171] Urasawa N, Wada MR, Machida N, Yuasa K, Shimatsu Y, Wakao Y, Yuasa S, Sano T, Nonaka I, Nakamura A, Takeda S, Selective vacuolar degeneration in dystrophin-deficient canine Purkinje fibers despite preservation of dystrophin-associated proteins with overexpression of Dp71. Circulation. 2008 May 13;117(19):2437-48. Epub 2008 May 5.