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XSB1943 : tumor protein p53 mutant form [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0053

* Basic Information

OrganismHomo sapiens (human)
Protein NamesCellular tumor antigen p53; tumor protein p53 mutant form
Gene NamesTP53
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
CAJ28924 N/A N/A Q1MSW9 N/A 11998 N/A hsa:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 285 aa

Average Mass: 31.566 kDa

Monoisotopic Mass: 31.545 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
P53_TAD 1. 52946.41.1e-10
--- cleavage 25 (inside P53_TAD 5..29) ---
P53 1. 95270401.02.1e-117

3. Sequence Information

Fasta Sequence: XSB1943.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] QETFSDLWKL25-LPENNVLSPL

Leu25 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gln16Glu17Thr18Phe19Ser20Asp21Leu22Trp23Lys24Leu25
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu26Pro27Glu28Asn29Asn30Val31Leu32Ser33Pro34Leu35

Sequence conservation (by blast)

* References

[PubMed ID: 17065008] Feuerborn A, Moritz C, Von Bonin F, Dobbelstein M, Trumper L, Sturzenhofecker B, Kube D, Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma. Leuk Lymphoma. 2006 Sep;47(9):1932-40.