XSB1971 : phosphoinositide-specific phospholipase C beta 1 isoform a [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0008
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; 3.1.4.11; Phosphoinositide phospholipase C; Phospholipase C-beta-1; PLC-beta-1; PLC-I; PLC-154; phosphoinositide-specific phospholipase C beta 1 isoform a; 1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase beta 1; triphosphoinositide phosphodiesterase; phosphoinositidase C; monophosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol-4; 5-bisphosphate; inositoltrisphosphohydrolase |
| Gene Names | PLCB1; KIAA0581; phospholipase C, beta 1 (phosphoinositide-specific) |
| Gene Locus | 20p12; chromosome 20 |
| GO Function | Not available |
* Information From OMIM
Description: Phospholipase C-beta (PLCB) catalyzes the generation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) from phosphatidylinositol 4,5-bisphosphate (IP2), a key step in the intracellular transduction of many extracellular signals. PLCB1 is one of several mammalian PLCB isoforms which differ in their function and expression patterns in vivo.
* Structure Information
1. Primary Information
Length: 1216 aa
Average Mass: 138.567 kDa
Monoisotopic Mass: 138.480 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Chitin_synth_1 1. | 92 | 181 | -119.6 | 3.6 |
| efhand_like 1. | 224 | 315 | 160.2 | 6e-45 |
| PI-PLC-X 1. | 318 | 468 | 327.6 | 2.6e-95 |
| PI-PLC-Y 1. | 539 | 656 | 297.8 | 2.3e-86 |
| C2 1. | 678 | 761 | 63.9 | 5.9e-16 |
| Big_4 1. | 835 | 897 | -11.8 | 5.7 |
| --- cleavage 880 (inside Big_4 835..897) --- | ||||
| DUF1154 1. | 903 | 946 | 6.2 | 0.0036 |
| PLC-beta_C 1. | 997 | 1189 | 414.4 | 1.9e-121 |
3. Sequence Information
Fasta Sequence: XSB1971.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] TPKPPSQALH880-SQPAPGSVKA
His880 
Ser
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Thr871 | Pro872 | Lys873 | Pro874 | Pro875 | Ser876 | Gln877 | Ala878 | Leu879 | His880 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser881 | Gln882 | Pro883 | Ala884 | Pro885 | Gly886 | Ser887 | Val888 | Lys889 | Ala890 |
Sequence conservation (by blast)
* References
[PubMed ID: 19240061] Trynka G, Zhernakova A, Romanos J, Franke L, Hunt K, Turner G, Platteel M, Ryan AW, de Kovel C, Barisani D, Bardella MT, McManus R, Van Heel DA, Wijmenga C, Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. Gut. 2009 Feb 24.