CaMPDB :: Substrate

XSB2031 : PREDICTED: similar to plasma membrane calcium ATPase 1 isoform 1b isoform 26 [Canis familiaris]

This entry is computationally expanded from SB0056

* Basic Information

Organism	Canis lupus familiaris (dog)
Protein Names	similar to plasma membrane calcium ATPase 1 isoform 1b isoform 26
Gene Names	ATP2B1; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 11 mRNAs, 286 ESTs, 165 Proteins
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
XP_865769	XM_860676	403480	N/A	N/A	N/A	N/A	N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 1251 aa

Average Mass: 137.937 kDa

Monoisotopic Mass: 137.850 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
efhand 1.	13	41	3.9	7.8
Cation_ATPase_N 1.	44	127	86.9	7.2e-23
E1-E2_ATPase 1.	158	496	227.7	2.9e-65
Hydrolase 1.	500	849	63.4	8.3e-16
Cation_ATPase_C 1.	910	1092	204.3	3.3e-58

3. Sequence Information

Fasta Sequence: XSB2031.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] EIDHAERELR¹¹³²-RGQILWFRGL

Arg¹¹³² Arg

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Glu¹¹²³	Ile¹¹²⁴	Asp¹¹²⁵	His¹¹²⁶	Ala¹¹²⁷	Glu¹¹²⁸	Arg¹¹²⁹	Glu¹¹³⁰	Leu¹¹³¹	Arg¹¹³²

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Arg¹¹³³	Gly¹¹³⁴	Gln¹¹³⁵	Ile¹¹³⁶	Leu¹¹³⁷	Trp¹¹³⁸	Phe¹¹³⁹	Arg¹¹⁴⁰	Gly¹¹⁴¹	Leu¹¹⁴²

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
AGHGTQKEEIPEEELAEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVNAFRSSLYEG

Summary

#	organism	max score	hits	top seq
1	Canis familiaris	91.30	103	PREDICTED: similar to plasma membrane calcium ATPa
2	N/A	91.30	40	A
3	Homo sapiens	91.30	27	plasma membrane calcium ATPase 1 isoform 1b
4	Bos taurus	91.30	12	plasma membrane calcium ATPase 1
5	Mus musculus	91.30	12	plasma membrane calcium ATPase 1
6	Gallus gallus	91.30	9	PREDICTED: similar to adenosine triphosphatase iso
7	Macaca mulatta	91.30	7	PREDICTED: similar to plasma membrane calcium ATPa
8	Monodelphis domestica	91.30	3	PREDICTED: similar to plasma membrane calcium ATPa
9	Sus scrofa	91.30	2	plasma membrane calcium ATPase 1
10	Rana catesbeiana	89.40	2	PMCA1bx
11	Tetraodon nigroviridis	84.30	4	unnamed protein product
12	Danio rerio	84.30	4	PREDICTED: hypothetical protein, partial
13	Rattus norvegicus	84.00	6	PREDICTED: similar to plasma membrane calcium ATPa
14	Pan troglodytes	82.00	11	PREDICTED: plasma membrane calcium ATPase 2 isofor
15	Oryctolagus cuniculus	80.90	1	Ca2+/Mg2+ ATPase
16	Pongo pygmaeus	75.90	1	hypothetical protein
17	synthetic construct	72.80	2	hypothetical protein
18	rats, ROS 17/2.8 osteosarcoma cells, Peptide Partial, 123 aa	71.20	1	plasma membrane Ca(2+)-ATPase PMCA1b isoform {alte
19	Procambarus clarkii	70.90	1	plasma membrane calcium ATPase PMCA3
20	Xenopus laevis	70.10	1	ATPase, Ca++ transporting, plasma membrane 3

Top-ranked sequences

organism	matching
Canis familiaris	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1103 AGHGTQKEEIPEEELAEDVEEIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162
N/A	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1072 AGHGTQKEEIPEEELAEDVEEIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1131
Homo sapiens	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1072 AGHGTQKEEIPEEELAEDVEEIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1131
Bos taurus	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1072 AGHGTQKEEIPEEELAEDVEEIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1131
Mus musculus	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1072 AGHGTQKEEIPEEELAEDVEEIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1131
Gallus gallus	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1070 AGHGTQKEEIPEEELAEDVEEIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1129
Macaca mulatta	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1098 AGHGTQKEEIPEEELAEDVEEIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1157
Monodelphis domestica	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1072 AGHGTQKEEIPEEELAEDVEEIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1131
Sus scrofa	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1072 AGHGTQKEEIPEEELAEDVEEIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1131
Rana catesbeiana	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\|\|\|\| \| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1066 AGHGTHKDEIPEEELAEDAEEIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1125
Tetraodon nigroviridis	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\| \|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 288 AGQLTQKDELPEEDVNEENEEIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 347
Danio rerio	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\| \|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 293 AGQLTQKDEMPEEEMNEDQEEIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 352
Rattus norvegicus	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\|\|\| \| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\| Sbjct 1069 AGHGPGKDEMTDEELAEGEEEIDHAERELR#RGQILWFRGLNRIQTQIRVVKAFRSSLYEG 1128
Pan troglodytes	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\| \|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\| Sbjct 1087 AGRLTQKEEIPEEELNEDVEEIDHAERELR#RGQILWFRGLNRIQTQIRVVKAFRSSLYEG 1146
Oryctolagus cuniculus	Query 1105 HGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\|\|\|\| \| \|\|\|\|\|\|\|#\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1074 HGTQKREIGEEELAEDVEEIVHAERELR#RWQILWFRGLNRIQTQIRVVNAFRSSLYEG 1131
Pongo pygmaeus	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRS 1157 \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+ \|\|\|\|\|+\| Sbjct 150 AGHGTQKEEIPEEELAEDVEEIDHAERELR#RGQILWFRGLNRIQTQMDVVNAFQS 204
synthetic construct	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYE 1161 \|\|\|\|\| \| \|\|\|\|\| \|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\| \|\| \|\|\|+\| Sbjct 1060 AGHGTTKEEITKDAEGLDE--IDHAEMELR#RGQILWFRGLNRIQTQIKVVKAFHSSLHE 1116
rats, ROS 17/2.8 osteosarcoma cells, Peptide Partial, 123 aa	Query 1129 RELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162 \|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1129 RELR#RGQILWFRGLNRIQTQIRVVNAFRSSLYEG 1162
Procambarus clarkii	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRS 1157 \|\|\| +\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|+\| Sbjct 1098 AGHEHRKDEMNAEDLNEGQEEIDHAERELR#RGQILWFRGLNRIQTQIEVVNAFKS 1152
Xenopus laevis	Query 1103 AGHGTQKXXXXXXXXXXXXXXIDHAERELR#RGQILWFRGLNRIQTQIRVVNAFRS 1157 \|\|+ \|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\| \|+\| Sbjct 1098 AGNLTQKEENQEEELNEDAEEIDHAERELR#RGQILWFRGLNRIQTQIEVVNTFKS 1152

* References

None.