XSB2052 : gap junction membrane channel protein alpha 8 [Mus musculus]
[ CaMP Format ]
This entry is computationally expanded from SB0016
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | Gap junction alpha-8 protein; Connexin-50; Cx50; Lens fiber protein MP70; gap junction membrane channel protein alpha 8; connexin 50; alpha 8 connexin; lens opacity 10 |
| Gene Names | Gja8; gap junction protein, alpha 8 |
| Gene Locus | 3 47.1 cM; chromosome 3 |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 440 aa
Average Mass: 49.598 kDa
Monoisotopic Mass: 49.566 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Connexin 1. | 3 | 129 | 311.9 | 1.3e-90 |
| Connexin_CCC 1. | 168 | 234 | 165.8 | 1.3e-46 |
| Connexin50 1. | 267 | 333 | 189.0 | 1.4e-53 |
| --- cleavage 290 (inside Connexin50 267..333) --- | ||||
3. Sequence Information
Fasta Sequence: XSB2052.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] IVSHYFPLTE290-VGMVETSPLS
Glu290 
Val
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ile281 | Val282 | Ser283 | His284 | Tyr285 | Phe286 | Pro287 | Leu288 | Thr289 | Glu290 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Val291 | Gly292 | Met293 | Val294 | Glu295 | Thr296 | Ser297 | Pro298 | Leu299 | Ser300 |
Sequence conservation (by blast)
* References
[PubMed ID: 19331825] DeRosa AM, Mese G, Li L, Sellitto C, Brink PR, Gong X, White TW, The cataract causing Cx50-S50P mutant inhibits Cx43 and intercellular communication in the lens epithelium. Exp Cell Res. 2009 Apr 1;315(6):1063-75. Epub 2009 Jan 30.