XSB2069 : microtubule-associated protein 2 isoform 5 [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0057
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Microtubule-associated protein; microtubule-associated protein 2 isoform 5 |
| Gene Names | MAP2; microtubule-associated protein 2 |
| Gene Locus | 2q34-q35; chromosome 2 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_001034627 | NM_001039538 | 4133 | Q8IUX2 | 157130 | 6839 | N/A | hsa:4133 |
* Information From OMIM
Function: Pregnenolone (PREG) and a synthetic analog, MePREG, bind to MAP2 and stimulate microtubule polymerization. Fontaine-Lenoir et al. (2006) found that PREG, MePREG, and progesterone (PROG), the metabolite of PREG, significantly enhanced neurite outgrowth of NGF (see NGFB; OMIM:162030)-treated rat PC12 pheochromocytoma cells. Map2 RNA interference prevented the stimulatory effect of PREG and MePREG, but not PROG, on neurite extension. Fontaine-Lenoir et al. (2006) concluded that MAP2 is a specific PREG and MePREG receptor.
* Structure Information
1. Primary Information
Length: 559 aa
Average Mass: 58.954 kDa
Monoisotopic Mass: 58.919 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| RII_binding_1 1. | 86 | 103 | 19.2 | 0.017 |
| --- cleavage 99 (inside RII_binding_1 86..103) --- | ||||
| Tubulin-binding 1. | 361 | 392 | 64.3 | 4.4e-16 |
| Tubulin-binding 2. | 393 | 423 | 64.9 | 3.1e-16 |
| Tubulin-binding 3. | 424 | 454 | 66.0 | 1.4e-16 |
| Tubulin-binding 4. | 455 | 486 | 55.1 | 2.6e-13 |
3. Sequence Information
Fasta Sequence: XSB2069.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] VSARIVQVVT99-AEAVAVLKGE
Thr99 
Ala
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val90 | Ser91 | Ala92 | Arg93 | Ile94 | Val95 | Gln96 | Val97 | Val98 | Thr99 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala100 | Glu101 | Ala102 | Val103 | Ala104 | Val105 | Leu106 | Lys107 | Gly108 | Glu109 |
Sequence conservation (by blast)
* References
[PubMed ID: 19369632] Gambichler T, Rotterdam S, Radkowski K, Altmeyer P, Kreuter A, Differential expression of microtubule-associated protein 2 in melanocytic skin lesions. Am J Clin Pathol. 2009 May;131(5):710-4.