logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2079 : unknown [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0093

* Basic Information

OrganismHomo sapiens (human)
Protein NamesAmphiphysin; unknown
Gene NamesAMPH; AMPH1
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAS07541 N/A N/A P49418 N/A N/A N/A hsa:273

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 563 aa

Average Mass: 60.857 kDa

Monoisotopic Mass: 60.820 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
ATP-synt_DE 1. 951-0.85.4
GnsAB 1. 76125-3.64.1
--- cleavage 201 ---
--- cleavage 260 ---
--- cleavage 245 ---
Ribosomal_60s 1. 299376-34.96.9
--- cleavage 322 (inside Ribosomal_60s 299..376) ---
--- cleavage 346 (inside Ribosomal_60s 299..376) ---
--- cleavage 399 ---
--- cleavage 477 ---
--- cleavage 461 ---
--- cleavage 395 ---
SH3_1 1. 49356224.10.00017

3. Sequence Information

Fasta Sequence: XSB2079.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1KY7 (X-ray; 215 A; P=322-331), 1UTC (X-ray; 230 A; P/Q=379-387)

* Cleavage Information

9 [sites]

Cleavage sites (±10aa)

[Site 1] TPAVGLDLGM322-DTRAEEPVEE

Met322 Asp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Thr313Pro314Ala315Val316Gly317Leu318Asp319Leu320Gly321Met322
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asp323Thr324Arg325Ala326Glu327Glu328Pro329Val330Glu331Glu332

Sequence conservation (by blast)

[Site 2] SAQPEAEELE399-ATVPQEKVIP

Glu399 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ser390Ala391Gln392Pro393Glu394Ala395Glu396Glu397Leu398Glu399
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala400Thr401Val402Pro403Gln404Glu405Lys406Val407Ile408Pro409

Sequence conservation (by blast)

[Site 3] APAMGAADQL477-ASAREASQEL

Leu477 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala468Pro469Ala470Met471Gly472Ala473Ala474Asp475Gln476Leu477
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala478Ser479Ala480Arg481Glu482Ala483Ser484Gln485Glu486Leu487

Sequence conservation (by blast)

[Site 4] PGADADAAVG346-TLVSAAEGAP

Gly346 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro337Gly338Ala339Asp340Ala341Asp342Ala343Ala344Val345Gly346
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Thr347Leu348Val349Ser350Ala351Ala352Glu353Gly354Ala355Pro356

Sequence conservation (by blast)

[Site 5] FEDNFVPEIS201-VTTPSQNEVP

Ser201 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Phe192Glu193Asp194Asn195Phe196Val197Pro198Glu199Ile200Ser201
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val202Thr203Thr204Pro205Ser206Gln207Asn208Glu209Val210Pro211

Sequence conservation (by blast)

[Site 6] LATEQKPIQD461-PQPTPSAPAM

Asp461 Pro

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Leu452Ala453Thr454Glu455Gln456Lys457Pro458Ile459Gln460Asp461
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Pro462Gln463Pro464Thr465Pro466Ser467Ala468Pro469Ala470Met471

Sequence conservation (by blast)

[Site 7] EGAESAQPEA395-EELEATVPQE

Ala395 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu386Gly387Ala388Glu389Ser390Ala391Gln392Pro393Glu394Ala395
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu396Glu397Leu398Glu399Ala400Thr401Val402Pro403Gln404Glu405

Sequence conservation (by blast)

[Site 8] DLWTTSTDLV260-QPASGGSFNG

Val260 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asp251Leu252Trp253Thr254Thr255Ser256Thr257Asp258Leu259Val260
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gln261Pro262Ala263Ser264Gly265Gly266Ser267Phe268Asn269Gly270

Sequence conservation (by blast)

[Site 9] SAGVTHSPMS245-QTLPWDLWTT

Ser245 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ser236Ala237Gly238Val239Thr240His241Ser242Pro243Met244Ser245
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gln246Thr247Leu248Pro249Trp250Asp251Leu252Trp253Thr254Thr255

Sequence conservation (by blast)

* References

[PubMed ID: 12853948] Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK, The DNA sequence of human chromosome 7. Nature. 2003 Jul 10;424(6945):157-64.