CaMPDB :: Substrate

XSB2089 : PREDICTED: gamma filamin [Pan troglodytes]

This entry is computationally expanded from SB0092

* Basic Information

Organism	Pan troglodytes (chimpanzee)
Protein Names	gamma filamin
Gene Names	FLNC; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 1 Protein
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
XP_519364	XM_519364	463711	N/A	N/A	N/A	N/A	N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 2571 aa

Average Mass: 275.870 kDa

Monoisotopic Mass: 275.697 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
CH 1.	14	107	77.5	4.7e-20
CH 2.	125	227	99.6	1.1e-26
Filamin 1.	237	330	127.8	3.5e-35
Filamin 2.	337	430	124.5	3.4e-34
Filamin 3.	436	527	134.0	4.7e-37
Filamin 4.	533	620	117.8	3.6e-32
Filamin 5.	629	720	147.4	4.5e-41
Filamin 6.	721	774	9.4	0.0019
Filamin 7.	780	873	123.5	6.7e-34
Filamin 8.	908	1046	91.0	4.2e-24
Filamin 9.	1052	1141	149.3	1.1e-41
Filamin 10.	1147	1241	124.3	4e-34
Filamin 11.	1247	1335	80.3	6.8e-21
Filamin 12.	1341	1431	147.1	5.5e-41
Filamin 13.	1437	1528	143.8	5.5e-40
Filamin 14.	1534	1632	101.6	2.7e-27
Filamin 15.	1724	1801	21.7	0.00014
Filamin 16.	1806	1893	156.4	8.4e-44
Filamin 17.	1894	1980	19.2	0.00024
Filamin 18.	1988	2075	149.6	9.6e-42
Filamin 19.	2166	2253	39.9	1e-08
Filamin 20.	2261	2348	137.9	3.2e-38
Filamin 21.	2355	2443	65.0	2.8e-16
--- cleavage 2472 ---
Filamin 22.	2478	2567	116.6	8e-32

3. Sequence Information

Fasta Sequence: XSB2089.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] SSSSRGSSYS²⁴⁷²-SIPKFSSDAS

Ser²⁴⁷² Ser

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Ser²⁴⁶³	Ser²⁴⁶⁴	Ser²⁴⁶⁵	Ser²⁴⁶⁶	Arg²⁴⁶⁷	Gly²⁴⁶⁸	Ser²⁴⁶⁹	Ser²⁴⁷⁰	Tyr²⁴⁷¹	Ser²⁴⁷²

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ser²⁴⁷³	Ile²⁴⁷⁴	Pro²⁴⁷⁵	Lys²⁴⁷⁶	Phe²⁴⁷⁷	Ser²⁴⁷⁸	Ser²⁴⁷⁹	Asp²⁴⁸⁰	Ala²⁴⁸¹	Ser²⁴⁸²

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
LSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSF

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	94.40	30	filamin, muscle isoform
2	Mus musculus	94.40	24	PREDICTED: similar to Filamin-C (Gamma-filamin) (F
3	Canis familiaris	94.40	21	PREDICTED: similar to Filamin C (Gamma-filamin) (F
4	N/A	94.40	16	F
5	Pan troglodytes	94.40	16	PREDICTED: gamma filamin
6	Bos taurus	94.40	6	PREDICTED: similar to filamin, muscle isoform 2
7	Rattus norvegicus	94.40	5	PREDICTED: similar to Filamin-C (Gamma-filamin) (F
8	Xenopus laevis	87.00	5	Unknown (protein for IMAGE:6940151)
9	Gallus gallus	80.50	4	cgABP260
10	Danio rerio	80.10	5	PREDICTED: similar to gamma-filamin
11	Tetraodon nigroviridis	66.20	4	unnamed protein product
12	Xenopus tropicalis	58.90	1	hypothetical protein LOC779840
13	Oryctolagus cuniculus	57.80	1	FLNB_RABIT Filamin-B (FLN-B) (Beta-filamin) (Actin
14	Macaca mulatta	56.20	8	PREDICTED: filamin B, beta (actin binding protein
15	Sus scrofa	56.20	2	filamin B beta
16	Drosophila melanogaster	54.30	8	cheerio CG3937-PD, isoform D
17	Monodelphis domestica	52.40	1	PREDICTED: similar to filamin B, beta (actin bindi
18	Anopheles gambiae str. PEST	48.90	1	ENSANGP00000003616
19	Aedes aegypti	48.90	1	filamin, putative
20	Apis mellifera	44.30	1	PREDICTED: similar to cheerio CG3937-PB, isoform B
21	Strongylocentrotus purpuratus	40.80	3	PREDICTED: similar to ENSANGP00000003616
22	Euprymna scolopes	40.00	1	filamin
23	Caenorhabditis briggsae	37.70	1	Hypothetical protein CBG10541
24	Caenorhabditis elegans	37.40	2	Y66H1B.2b

Top-ranked sequences

organism	matching
Homo sapiens	Query 2443 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2564 LSGGHSLHETSTVLVETVTKSSSSRGSSYS#SIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2623
Mus musculus	Query 2443 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2517 LSGGHSLHETSTVLVETVTKSSSSRGASYS#SIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2576
Canis familiaris	Query 2443 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2443 LSGGHSLHETSTVLVETVTKSSSSRGSSYS#SIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502
N/A	Query 2443 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2597 LSGGHSLHETSTVLVETVTKSSSSRGSSYS#SIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2656
Pan troglodytes	Query 2443 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2443 LSGGHSLHETSTVLVETVTKSSSSRGSSYS#SIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502
Bos taurus	Query 2443 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2479 LSGGHSLHETSTVLVETVTKSSSSRGSSYS#SIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2538
Rattus norvegicus	Query 2443 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2517 LSGGHSLHETSTVLVETVTKSSSSRGASYS#SIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2576
Xenopus laevis	Query 2443 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|+\|\|\|\|\|\|\|+\| Sbjct 53 LSGGHSLHETSTVLVETVTKSSASVGEYGM#AGPKFSSDASKVVSRGPGLSKAFVGQKNTF 112
Gallus gallus	Query 2443 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|+ # +\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\| \|\|\|\|\|\|\| \| Sbjct 2531 LSGGHSLHETSSVLVETVTRGALGPPGFGT#-LPKFSSDASKVVARGPGLSTAFVGQKNHF 2589
Danio rerio	Query 2443 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\| # +\|\|\|\|\|\|\|\|\|\|\|+\|\| \|\|\|+\|\|+\|\|\|\|+\| Sbjct 2133 LSGGHSLHETSSVLVETVTKSSSVAGSFST#-LPKFSSDASKVVSRGAGLSKAFIGQKNTF 2191
Tetraodon nigroviridis	Query 2443 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\| \|\| \| \|\|\|+\|\|\|\|\|\|+\| # \|\|\|\|\|\|\|\|+\|+ \|\| \|\|\|+\|\|+ \|\|\|\|\| Sbjct 2744 LSSGHGLRETSSVLVETVSKSTAKGAAFAS#-FPKFSSDASQVLLRGAGLSKAFISQKNSF 2802
Xenopus tropicalis	Query 2447 HSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|\|\|\|+\|+\| \|++\|\|\| # \|+ +\|\|\|\|\|\|\| +\| \|\|++\|\|\|\|\|\|\|\|\| Sbjct 95 HSLHESSSVFVDSVTKSEAFTQHAAA#--PRIASDASKVVAKGLGLNKAFVGQKNSF 148
Oryctolagus cuniculus	Query 2443 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \| \| \| +\|\|\|++\|\|\|+\|\|+ # \|\|\| \|\|\|\|\|\|\| ++\| \|\|\|+\|\|\|\|\|\|+\|\| Sbjct 168 LVGPGSTNETSSILVESVTRSSTETCYSA-#-IPKASSDASKVTSKGAGLSKAFVGQKSSF 225
Macaca mulatta	Query 2448 SLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \| +\|\|\|++\|\|\|+\|\|+ # \|\|\| \|\|\|\|\|\|\| ++\| \|\|\|+\|\|\|\|\|\|+\|\| Sbjct 2465 SANETSSILVESVTRSSTETCYSA-#-IPKASSDASKVTSKGAGLSKAFVGQKSSF 2517
Sus scrofa	Query 2448 SLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \| +\|\|\|++\|\|\|+\|\|+ # \|\|\| \|\|\|\|\|\|\| ++\| \|\|\|+\|\|\|\|\|\|+\|\| Sbjct 131 SANETSSILVESVTRSSTETCYSA-#-IPKASSDASKVTSKGAGLSKAFVGQKSSF 183
Drosophila melanogaster	Query 2451 ETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|\|\|\|+\|\|\|\| \| # +\| \| \|\|\|\|\|\|\|++\| \|\| +\|++\|++\| \| Sbjct 2421 ETSTVIVETVQKVAKGGKNTGV#HLPTFKSDASKVVSKGMGLKKAYIGKQNQF 2472
Monodelphis domestica	Query 2448 SLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \| +\|\|\|++\|\|\|+\|\|+ # +\|\| \|\|\|\|\|\|\| ++\| \|\| +\|\|\|\|\|\|++\| Sbjct 37 SANETSSILVESVTRSSTETCYSA-#-VPKASSDASKVTSKGAGLVKAFVGQKSTF 89
Anopheles gambiae str. PEST	Query 2451 ETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|\|+\|+\|\|\|\| \| # +\| \| \|\|\|\|\|+ ++\| \|\| +\|++\|++\| \| Sbjct 2293 ETSSVIVETVAKVSKGGNRTGV#ILPIFKSDASKIQSKGMGLKKAYMGKQNQF 2344
Aedes aegypti	Query 2451 ETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|\|+\|+\|\|\|\| \| # +\| \| \|\|\|\|\|\| ++\| \|\| +\|++\|++\| \| Sbjct 2235 ETSSVVVETVAKVSKGGNRTGV#ILPIFKSDASKVQSKGMGLKKAYLGKQNQF 2286
Apis mellifera	Query 2451 ETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|\|+++\|\|\|\| \| # +\| \| \|\|\|\|\|\| ++\| \|\| +\|++\|++\| \| Sbjct 683 ETSSIVVETVQKISKAKQVGPV#-LPLFKSDASKVTSKGMGLKKAYLGKQNVF 733
Strongylocentrotus purpuratus	Query 2451 ETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|+ \|+\|\|\|+ \| # \| \|+\|\|\|\|\|\|\|+ \| \|\| ++\|+ +\|+ \| Sbjct 2168 ETAQVMVETIVKTTTTTGFQA-#--PVFTSDASKVVSSGMGLKKSFLNKKSQF 2216
Euprymna scolopes	Query 2446 GHS--LHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVG 2497 \|\|+ \|\| ++\|+\|\|\|\|\|\| # \| \| \|\|\|\|\|\|\| \| \|\| \|+ \| Sbjct 78 GHASGFHEQASVVVETVTKTSTTTRFSG-#-IQNFQSDASKVVANGAGLKTAYPG 129
Caenorhabditis briggsae	Query 2445 GGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|+ +\|\|\| \| ++ \| \| # +\|+++ \|\|+\|\| +\| \|\|++ \| \|+ +\| Sbjct 1241 GGNGYNETSHVKIDAVAKTSKGTVAV--#-VPEYAGDAAKVTAKGAGLNKFFPGRPAAF 1295
Caenorhabditis elegans	Query 2445 GGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502 \|\|+ +\|\|\| \| ++ \| \| # +\|++ \|\|+\|\| +\| \|\|++ \| \|+ +\| Sbjct 777 GGNGYNETSHVKIDAVAKTSKGTVAV--#-VPEYQGDAAKVTAKGAGLNKFFPGRPAAF 831

* References

None.