logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2112 : Filamin-C

[ CaMP Format ]

This entry is computationally expanded from SB0092

* Basic Information

OrganismHomo sapiens (human)
Protein NamesGamma-filamin; Filamin-2; Protein FLNc; Actin-binding-like protein; ABP-L; ABP-280-like protein
Gene NamesABPL, FLN2; ABPL; FLN2
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
Q14315 N/A N/A Q14315 N/A N/A N/A hsa:2318

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 2725 aa

Average Mass: 290.959 kDa

Monoisotopic Mass: 290.778 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
CH 1. 37142109.89.2e-30
CH 2. 16026298.91.8e-26
Filamin 1. 272365128.22.6e-35
Filamin 2. 372465124.53.4e-34
Filamin 3. 471562134.04.7e-37
Filamin 4. 568655117.83.6e-32
Filamin 5. 664755146.11.1e-40
Filamin 6. 761858142.01.8e-39
Filamin 7. 864957123.56.7e-34
Filamin 8. 9631053108.22.8e-29
Filamin 9. 10591146151.52.5e-42
Filamin 10. 11521241149.31.1e-41
Filamin 11. 12471341124.34e-34
Filamin 12. 13471434156.48.5e-44
Filamin 13. 14401530147.15.5e-41
Filamin 14. 15361627140.84.4e-39
Filamin 15. 16331731101.62.7e-27
Filamin 16. 1774185121.70.00014
Filamin 17. 18561943156.48.4e-44
Filamin 18. 1944203019.20.00024
Filamin 19. 20382125149.69.6e-42
Filamin 20. 2216230341.04.9e-09
Filamin 21. 23112398127.06.1e-35
Filamin 22. 2405249386.78.4e-23
Filamin 23. 25022589123.19.1e-34
--- cleavage 2626 ---
Filamin 24. 26322721116.68e-32

3. Sequence Information

Fasta Sequence: XSB2112.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1V05 (X-ray; 143 A; A=2633-2725), 2D7M (NMR; -; A=1536-1637), 2D7N (NMR; -; A=1782-1861), 2D7O (NMR; -; A=1856-1953), 2D7P (NMR; -; A=2405-2500), 2D7Q (NMR; -; A=2502-2599), 2NQC (X-ray; 205 A; A=2495-2598)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] SSSSRGSSYS2626-SIPKFSSDAS

Ser2626 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ser2617Ser2618Ser2619Ser2620Arg2621Gly2622Ser2623Ser2624Tyr2625Ser2626
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser2627Ile2628Pro2629Lys2630Phe2631Ser2632Ser2633Asp2634Ala2635Ser2636

Sequence conservation (by blast)

* References

[PubMed ID: 9791010] Xie Z, Xu W, Davie EW, Chung DW, Molecular cloning of human ABPL, an actin-binding protein homologue. Biochem Biophys Res Commun. 1998 Oct 29;251(3):914-9.

» More (20)