logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2114 : filamin, muscle isoform [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0092

* Basic Information

OrganismHomo sapiens (human)
Protein NamesFilamin-C; Gamma-filamin; Filamin-2; Protein FLNc; Actin-binding-like protein; ABP-L; ABP-280-like protein; filamin; muscle isoform
Gene NamesABPL, FLN2; ABPL; FLN2
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
CAB46442 N/A N/A Q14315 N/A 3756 N/A hsa:2318

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 2692 aa

Average Mass: 287.356 kDa

Monoisotopic Mass: 287.177 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
CH 1. 37142103.95.4e-28
CH 2. 16026291.23.7e-24
Filamin 1. 272365128.22.6e-35
Filamin 2. 372465124.53.4e-34
Filamin 3. 471562128.71.8e-35
Filamin 4. 568655117.83.6e-32
Filamin 5. 664755147.44.5e-41
Filamin 6. 761858142.01.8e-39
Filamin 7. 864957123.56.7e-34
Filamin 8. 9631053108.22.8e-29
Filamin 9. 10591146147.73.6e-41
Filamin 10. 11521241149.31.1e-41
Filamin 11. 12471341124.34e-34
Filamin 12. 13471434156.48.5e-44
Filamin 13. 14401530147.15.5e-41
Filamin 14. 15361627141.03.7e-39
Filamin 15. 1633173194.53.8e-25
Filamin 16. 1741181821.70.00014
Filamin 17. 18231910156.48.4e-44
Filamin 18. 1911199719.20.00024
Filamin 19. 20052092148.61.9e-41
Filamin 20. 2183227041.04.9e-09
Filamin 21. 22782365137.93.2e-38
Filamin 22. 2372246086.78.4e-23
Filamin 23. 24692556123.19.1e-34
--- cleavage 2593 ---
Filamin 24. 25992688116.68e-32

3. Sequence Information

Fasta Sequence: XSB2114.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1V05 (X-ray; 143 A; A=2633-2725), 2D7M (NMR; -; A=1536-1637), 2D7N (NMR; -; A=1782-1861), 2D7O (NMR; -; A=1856-1953), 2D7P (NMR; -; A=2405-2500), 2D7Q (NMR; -; A=2502-2599), 2NQC (X-ray; 205 A; A=2495-2598)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] SSSSRGSSYS2593-SIPKFSSDAS

Ser2593 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ser2584Ser2585Ser2586Ser2587Arg2588Gly2589Ser2590Ser2591Tyr2592Ser2593
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser2594Ile2595Pro2596Lys2597Phe2598Ser2599Ser2600Asp2601Ala2602Ser2603

Sequence conservation (by blast)

* References

None.