XSB2120 : Beta-crystallin B3
[ CaMP Format ]
This entry is computationally expanded from SB0095
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Beta-B3 crystallin |
| Gene Names | CRYB3 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 211 aa
Average Mass: 24.230 kDa
Monoisotopic Mass: 24.215 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| --- cleavage 15 --- | ||||
| Crystall 1. | 25 | 107 | 148.3 | 2.3e-41 |
| Crystall 2. | 115 | 197 | 159.0 | 1.4e-44 |
3. Sequence Information
Fasta Sequence: XSB2120.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] GAPEQAAAGK15-SHGDLGGSYK
Lys15 
Ser
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly6 | Ala7 | Pro8 | Glu9 | Gln10 | Ala11 | Ala12 | Ala13 | Gly14 | Lys15 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser16 | His17 | Gly18 | Asp19 | Leu20 | Gly21 | Gly22 | Ser23 | Tyr24 | Lys25 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| MAEQHGAPEQAAAGKSHGDLGGSYKVILYELENFQGKRCELSAEC |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 96.70 | 6 | Crystallin, beta B3 |
| 2 | Pan troglodytes | 91.30 | 5 | PREDICTED: crystallin, beta B3 isoform 1 |
| 3 | Mus musculus | 90.90 | 5 | crystallin, beta B3 |
| 4 | Macaca mulatta | 90.90 | 3 | PREDICTED: crystallin, beta B2 isoform 1 |
| 5 | Cavia porcellus | 89.40 | 3 | betaB3-crystallin |
| 6 | N/A | 88.60 | 8 | C |
| 7 | Rattus norvegicus | 88.60 | 7 | crystallin, beta B3 |
| 8 | Ovis aries | 88.60 | 1 | crystallin, beta B3 |
| 9 | Bos taurus | 87.00 | 4 | crystallin, beta B3 |
| 10 | Xenopus laevis | 74.70 | 8 | MGC84109 protein |
| 11 | Danio rerio | 62.40 | 13 | beta B3-crystallin |
| 12 | Gallus gallus | 61.20 | 3 | crystallin, beta B3 |
| 13 | Tetraodon nigroviridis | 60.10 | 5 | unnamed protein product |
| 14 | Sus scrofa | 40.40 | 1 | beta crystallin subunit beta B1 |
| 15 | Canis familiaris | 40.00 | 1 | PREDICTED: similar to crystallin, beta B1 |
| 16 | Dicentrarchus labrax | 40.00 | 1 | crystallin beta B1 |
| 17 | synthetic construct | 39.70 | 1 | crystallin beta B1 |
| 18 | Monodelphis domestica | 38.50 | 3 | PREDICTED: similar to betaB2-crystallin |
| 19 | Xenopus tropicalis | 38.10 | 2 | crystallin, beta B1 |
| 20 | Contains: Beta crystallin B1B | 38.10 | 1 | CRBB1_RAT Beta crystallin B1 |
| 21 | Cynops pyrrhogaster | 37.40 | 1 | newt beta B1-crystallin |
| 22 | Iguana iguana | 35.40 | 1 | betaA2-crystallin |
| 23 | Oryctolagus cuniculus | 33.90 | 2 | beta A3-crystallin |
| 24 | Contains: Beta crystallin A3, isoform A1, Delta4 form; Beta crystallin A3, isoform A1, Delta7 form; Beta crystallin A3, isoform A1, Delta8 form | 33.90 | 1 | CRBA1_BOVIN Beta crystallin A3 |
| 25 | Canis lupus familiaris | 33.90 | 1 | crystallin, beta A1 |
| 26 | Rana catesbeiana | 33.50 | 4 | CRB31_RANCA Beta crystallin A3-1 emb |
| 27 | Rana temporaria | 33.50 | 2 | unnamed protein product |
| 28 | Macropus fuliginosus | 33.10 | 1 | betaA2-crystallin |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1 MAEQHGAPEQAAAGK#SHGDLGGSYKVILYELENFQGKRCELSAEC 45 |||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MAEQHGAPEQAAAGK#SHGDLGGSYKVILYELENFQGKRCELSAEC 45 |
| Pan troglodytes | Query 1 MAEQHGAPEQAAAGK#SHGDLGGSYKVILYELENFQGKRCELSAEC 45 |||||| ||||||||#||| ||||||||+||||||||||||||||| Sbjct 1 MAEQHGTPEQAAAGK#SHGGLGGSYKVIVYELENFQGKRCELSAEC 45 |
| Mus musculus | Query 1 MAEQHGAPEQAAAGK#SHGDLGGSYKVILYELENFQGKRCELSAEC 45 |||||||||||||||#||| ||||||| +||||||||||||||||| Sbjct 1 MAEQHGAPEQAAAGK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 |
| Macaca mulatta | Query 1 MAEQHGAPEQAAAGK#SHGDLGGSYKVILYELENFQGKRCELSAEC 45 |||||||||||||||#||| ||||||||+||||||||| ||||||| Sbjct 1 MAEQHGAPEQAAAGK#SHGGLGGSYKVIVYELENFQGKHCELSAEC 45 |
| Cavia porcellus | Query 1 MAEQHGAPEQAAAGK#SHGDLGGSYKVILYELENFQGKRCELSAEC 45 |||||||||||||||#||| ||| ||| +||||||||||||||||| Sbjct 1 MAEQHGAPEQAAAGK#SHGGLGGGYKVTVYELENFQGKRCELSAEC 45 |
| N/A | Query 1 MAEQHGAPEQAAAGK#SHGDLGGSYKVILYELENFQGKRCELSAEC 45 ||||||||||||| |#||| ||||||| +||||||||||||||||| Sbjct 1 MAEQHGAPEQAAASK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 |
| Rattus norvegicus | Query 1 MAEQHGAPEQAAAGK#SHGDLGGSYKVILYELENFQGKRCELSAEC 45 ||||||||||||| |#||| ||||||| +||||||||||||||||| Sbjct 1 MAEQHGAPEQAAANK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 |
| Ovis aries | Query 1 MAEQHGAPEQAAAGK#SHGDLGGSYKVILYELENFQGKRCELSAEC 45 ||||| |||||||||#||| ||||||||+||+||||||||||+||| Sbjct 1 MAEQHSAPEQAAAGK#SHGGLGGSYKVIVYEMENFQGKRCELTAEC 45 |
| Bos taurus | Query 1 MAEQHGAPEQAAAGK#SHGDLGGSYKVILYELENFQGKRCELSAEC 45 ||||| ||||||||#||| ||||||||+||+||||||||||+||| Sbjct 1 MAEQHSTPEQAAAGK#SHGGLGGSYKVIVYEMENFQGKRCELTAEC 45 |
| Xenopus laevis | Query 1 MAEQHGAPEQAAAGK#SHGDLGGSYKVILYELENFQGKRCELSAEC 45 |+| |||| ||||#||| +||+||+ ||||||||||+|||+ || Sbjct 1 MSELQSAPEQMAAGK#SHGGIGGNYKITLYELENFQGKKCELTGEC 45 |
| Danio rerio | Query 1 MAEQHGAPEQAAAGK#SHGDLGGSYKVILYELENFQGKRCELSAEC 45 |++| | |+| |||#| | | ||| ||| |||+||+ |||||| Sbjct 1 MSDQQGVPDQQVAGK#SQGGAGAIYKVSLYEFENFRGKKLELSAEC 45 |
| Gallus gallus | Query 1 MAEQHGAPEQAAAGK#SHGDLGGSYKVILYELENFQGKRCELSAE 44 | || ||| |+# |+ ||+||+ +||||||||+||||| | Sbjct 1 MTEQQSPPEQMVTGE#GAGERGGNYKITIYELENFQGRRCELSEE 44 |
| Tetraodon nigroviridis | Query 1 MAEQHGAPEQAAAGK#SHGDLGGSYKVILYELENFQGKRCELSAEC 45 |+|+ |||| ||||#| | | +|||+|+| ||||| + | |++| Sbjct 33 MSERQSAPEQLAAGK#SQGGAGATYKVLLFEFENFQGCKAEFSSDC 77 |
| Sus scrofa | Query 8 PEQAAAGK---#SHGDLG-GSYKVILYELENFQGKRCELSAEC 45 | || | #+ ||| ||||++++| |||||+| | | || Sbjct 36 PAQAPAQPMPA#AKGDLPPGSYKLVVFEQENFQGRRVEFSGEC 77 |
| Canis familiaris | Query 18 GDLG-GSYKVILYELENFQGKRCELSAEC 45 ||| ||||++++| |||||+| | | || Sbjct 48 GDLPPGSYKLVVFEQENFQGRRVEFSGEC 76 |
| Dicentrarchus labrax | Query 2 AEQHGAPEQAAAGK#SH--GDLG-GSYKVILYELENFQGKRCELSAEC 45 |+ ||| ||+ |#+ |+ | |||++++++ |||||+ |+ || Sbjct 15 AKDKGAPAPAASSK#ATKTGEPGMGSYRIMMFDQENFQGRMIEVQNEC 61 |
| synthetic construct | Query 22 GSYKVILYELENFQGKRCELSAEC 45 |+|+++++|||||||+| | | || Sbjct 57 GNYRLVVFELENFQGRRAEFSGEC 80 |
| Monodelphis domestica | Query 1 MAEQHGAPEQAAAGK#SHGDLGGSYK 25 | || ||||||||#||| ||||+| Sbjct 125 MMEQQSVPEQAAAGK#SHGGLGGSFK 149 Query 23 SYKVILYELENFQGKRCELSAEC 45 | +| ++||||||||+|+|| || Sbjct 215 SLQVSIFELENFQGKKCDLSTEC 237 |
| Xenopus tropicalis | Query 7 APEQAAAGK#SHGD-LGGSYKVILYELENFQGKRCELSAEC 45 || +| # || + ||+|++|+| |||||+ || || Sbjct 19 APVPSAKPT#RTGDPMMGSFKIVLFEQENFQGRHVELLNEC 58 |
| Contains: Beta crystallin B1B | Query 22 GSYKVILYELENFQGKRCELSAEC 45 |||+++++| |||||+| | | || Sbjct 55 GSYRLVVFEQENFQGRRVEFSGEC 78 |
| Cynops pyrrhogaster | Query 2 AEQHGAPEQAAAGK#SH--GDLG-GSYKVILYELENFQGKRCELSAEC 45 +++ | | |# + || |+||+|++| |||||+ || || Sbjct 23 SKEKGVPPSVPISK#PNKAGDSSVGTYKIIIFEQENFQGRHLELVNEC 69 |
| Iguana iguana | Query 22 GSYKVILYELENFQGKRCELSAEC 45 | +|+ ++| |||||+||| || Sbjct 3 GQFKITVWEEENFQGERCEFLMEC 26 |
| Oryctolagus cuniculus | Query 22 GSYKVILYELENFQGKRCELSAEC 45 | +|+ +|+ ||||||| | ++ | Sbjct 29 GPWKITIYDQENFQGKRMEFTSSC 52 |
| Contains: Beta crystallin A3, isoform A1, Delta4 form; Beta crystallin A3, isoform A1, Delta7 form; Beta crystallin A3, isoform A1, Delta8 form | Query 22 GSYKVILYELENFQGKRCELSAEC 45 | +|+ +|+ ||||||| | ++ | Sbjct 29 GPWKITIYDQENFQGKRMEFTSSC 52 |
| Canis lupus familiaris | Query 22 GSYKVILYELENFQGKRCELSAEC 45 | +|+ +|+ ||||||| | ++ | Sbjct 29 GPWKITIYDQENFQGKRMEFTSSC 52 |
| Rana catesbeiana | Query 22 GSYKVILYELENFQGKRCELSAEC 45 | +|+ +|+ ||||||| | ++ | Sbjct 29 GPWKITVYDQENFQGKRMEFTSSC 52 |
| Rana temporaria | Query 22 GSYKVILYELENFQGKRCELSAEC 45 | +|+ +|+ ||||||| | ++ | Sbjct 12 GPWKITVYDQENFQGKRMEFTSSC 35 |
| Macropus fuliginosus | Query 25 KVILYELENFQGKRCELSAEC 45 ++ |+| |||||+|||| ++| Sbjct 13 RLTLWEEENFQGRRCELMSDC 33 |
* References
[PubMed ID: 8999933] Lampi KJ, Ma Z, Shih M, Shearer TR, Smith JB, Smith DL, David LL, Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens. J Biol Chem. 1997 Jan 24;272(4):2268-75.
[PubMed ID: 2499686] ... Aarts HJ, Jacobs EH, van Willigen G, Lubsen NH, Schoenmakers JG, Different evolution rates within the lens-specific beta-crystallin gene family. J Mol Evol. 1989 Apr;28(4):313-21.
[PubMed ID: 15461802] ... Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I, A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. 2004;5(10):R84. Epub 2004 Sep 30.
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[PubMed ID: 15914629] ... Riazuddin SA, Yasmeen A, Yao W, Sergeev YV, Zhang Q, Zulfiqar F, Riaz A, Riazuddin S, Hejtmancik JF, Mutations in betaB3-crystallin associated with autosomal recessive cataract in two Pakistani families. Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2100-6.