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XSB2122 : amphiphysin I variant NC1 [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0093

* Basic Information

OrganismHomo sapiens (human)
Protein Namesamphiphysin I variant NC1
Gene NamesAMPH
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAM44810 N/A N/A Q8NFL4 N/A N/A N/A hsa:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 583 aa

Average Mass: 62.173 kDa

Monoisotopic Mass: 62.135 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 89 ---
Attractin 1. 141191-13.65.1
--- cleavage 419 ---
--- cleavage 497 ---
--- cleavage 481 ---
--- cleavage 415 ---
SH3_1 1. 51358224.10.00017

3. Sequence Information

Fasta Sequence: XSB2122.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

5 [sites]

Cleavage sites (±10aa)

[Site 1] SAQPEAEELE419-ATVPQEKVIP

Glu419 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ser410Ala411Gln412Pro413Glu414Ala415Glu416Glu417Leu418Glu419
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala420Thr421Val422Pro423Gln424Glu425Lys426Val427Ile428Pro429

Sequence conservation (by blast)

[Site 2] APAMGAADQL497-ASAREASQEL

Leu497 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala488Pro489Ala490Met491Gly492Ala493Ala494Asp495Gln496Leu497
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala498Ser499Ala500Arg501Glu502Ala503Ser504Gln505Glu506Leu507

Sequence conservation (by blast)

[Site 3] FEDNFVPEIS89-VTTPSQNEVP

Ser89 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Phe80Glu81Asp82Asn83Phe84Val85Pro86Glu87Ile88Ser89
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val90Thr91Thr92Pro93Ser94Gln95Asn96Glu97Val98Pro99

Sequence conservation (by blast)

[Site 4] LATEQKPIQD481-PQPTPSAPAM

Asp481 Pro

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Leu472Ala473Thr474Glu475Gln476Lys477Pro478Ile479Gln480Asp481
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Pro482Gln483Pro484Thr485Pro486Ser487Ala488Pro489Ala490Met491

Sequence conservation (by blast)

[Site 5] EGAESAQPEA415-EELEATVPQE

Ala415 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu406Gly407Ala408Glu409Ser410Ala411Gln412Pro413Glu414Ala415
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu416Glu417Leu418Glu419Ala420Thr421Val422Pro423Gln424Glu425

Sequence conservation (by blast)

* References

[PubMed ID: 12023042] Terada Y, Tsutsui K, Sano K, Hosoya O, Ohtsuki H, Tokunaga A, Tsutsui K, Novel splice variants of amphiphysin I are expressed in retina. FEBS Lett. 2002 May 22;519(1-3):185-90.