logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2123 : amphiphysin I variant CT2 [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0093

* Basic Information

OrganismHomo sapiens (human)
Protein Namesamphiphysin I variant CT2
Gene NamesAMPH
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAM44806 N/A N/A Q8NFL8 N/A N/A N/A hsa:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 452 aa

Average Mass: 48.147 kDa

Monoisotopic Mass: 48.118 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Attractin 1. 1060-13.65.1
--- cleavage 288 ---
--- cleavage 366 ---
--- cleavage 350 ---
--- cleavage 284 ---
SH3_1 1. 38245124.10.00017

3. Sequence Information

Fasta Sequence: XSB2123.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites]

Cleavage sites (±10aa)

[Site 1] SAQPEAEELE288-ATVPQEKVIP

Glu288 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ser279Ala280Gln281Pro282Glu283Ala284Glu285Glu286Leu287Glu288
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala289Thr290Val291Pro292Gln293Glu294Lys295Val296Ile297Pro298

Sequence conservation (by blast)

[Site 2] APAMGAADQL366-ASAREASQEL

Leu366 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala357Pro358Ala359Met360Gly361Ala362Ala363Asp364Gln365Leu366
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala367Ser368Ala369Arg370Glu371Ala372Ser373Gln374Glu375Leu376

Sequence conservation (by blast)

[Site 3] LATEQKPIQD350-PQPTPSAPAM

Asp350 Pro

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Leu341Ala342Thr343Glu344Gln345Lys346Pro347Ile348Gln349Asp350
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Pro351Gln352Pro353Thr354Pro355Ser356Ala357Pro358Ala359Met360

Sequence conservation (by blast)

[Site 4] EGAESAQPEA284-EELEATVPQE

Ala284 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu275Gly276Ala277Glu278Ser279Ala280Gln281Pro282Glu283Ala284
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu285Glu286Leu287Glu288Ala289Thr290Val291Pro292Gln293Glu294

Sequence conservation (by blast)

* References

[PubMed ID: 12023042] Terada Y, Tsutsui K, Sano K, Hosoya O, Ohtsuki H, Tokunaga A, Tsutsui K, Novel splice variants of amphiphysin I are expressed in retina. FEBS Lett. 2002 May 22;519(1-3):185-90.