XSB2127 : PREDICTED: amphiphysin isoform 3 [Macaca mulatta]
[ CaMP Format ]
This entry is computationally expanded from SB0093
* Basic Information
| Organism | Macaca mulatta (rhesus monkey) |
| Protein Names | amphiphysin isoform 3 |
| Gene Names | AMPH; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 9 mRNAs, 54 ESTs, 8 Proteins |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 829 aa
Average Mass: 91.023 kDa
Monoisotopic Mass: 90.967 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| BAR 1. | 13 | 233 | 288.1 | 1.9e-83 |
| --- cleavage 336 --- |
| Attractin 1. | 388 | 438 | -13.7 | 5.2 |
| APC_CDC26 1. | 541 | 617 | -27.0 | 5.9 |
| --- cleavage 666 --- |
| --- cleavage 662 --- |
| SH3_1 1. | 759 | 828 | 24.1 | 0.00017 |
3. Sequence Information
Fasta Sequence: XSB2127.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
3 [sites]
Cleavage sites (±10aa)
[Site 1] AQAEAEELAA666-TVPQEKVIPS
Ala666 
Thr
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Ala657 | Gln658 | Ala659 | Glu660 | Ala661 | Glu662 | Glu663 | Leu664 | Ala665 | Ala666 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Thr667 | Val668 | Pro669 | Gln670 | Glu671 | Lys672 | Val673 | Ile674 | Pro675 | Ser676 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
GEGVSLEEAKIGTETEGAESAQAEAEELAATVPQEKVIPSVVIEPASNHEEEGEHEITIG
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Macaca mulatta |
51.60 |
3 |
PREDICTED: amphiphysin isoform 3 |
| 2 |
Homo sapiens |
47.00 |
8 |
amphiphysin isoform 1 |
| 3 |
Pan troglodytes |
47.00 |
1 |
PREDICTED: amphiphysin |
| 4 |
synthetic construct |
47.00 |
1 |
amphiphysin |
| 5 |
Rattus norvegicus |
35.00 |
1 |
amphiphysin 1 |
| 6 |
Bos taurus |
34.30 |
1 |
hypothetical protein LOC614722 |
| 7 |
Canis familiaris |
33.50 |
1 |
PREDICTED: similar to Amphiphysin |
Top-ranked sequences
| organism | matching |
|---|
| Macaca mulatta |
Query 637 GEGVSLEEAKIGXXXXXXXXXXXXXXXXXX#XVPQEKVIPSVVIEPASN 684
|||||||||||| # |||||||||||||||||
Sbjct 637 GEGVSLEEAKIGTETEGAESAQAEAEELAA#TVPQEKVIPSVVIEPASN 684
|
| Homo sapiens |
Query 637 GEGVSLEEAKIGXXXXXXXXXXXXXXXXXX#X-VPQEKVIPSVVIEPASN 684
|||||||||||| # |||||||||||||||||
Sbjct 502 GEGVSLEEAKIGTETTEGAESAQPEAEELE#ATVPQEKVIPSVVIEPASN 550
|
| Pan troglodytes |
Query 637 GEGVSLEEAKIGXXXXXXXXXXXXXXXXXX#X-VPQEKVIPSVVIEPASN 684
|||||||||||| # |||||||||||||||||
Sbjct 737 GEGVSLEEAKIGTETTEGAESAQPEAEELE#VTVPQEKVIPSVVIEPASN 785
|
| synthetic construct |
Query 637 GEGVSLEEAKIGXXXXXXXXXXXXXXXXXX#X-VPQEKVIPSVVIEPASN 684
|||||||||||| # |||||||||||||||||
Sbjct 502 GEGVSLEEAKIGTETTEGAESAQPEAEELE#ATVPQEKVIPSVVIEPASN 550
|
| Rattus norvegicus |
Query 669 PQEKVIPSVVIEPASN 684
||||||||||||||||
Query 669 PQEKVIPSVVIEPASN 684
|
| Bos taurus |
Query 637 GEGVSLEEAKIGXXXXXXXXXXXXXXXXXX#XVP-QEKVIPSVVIEPASN 684
| | |||||| # | ||||||||||+||||
Sbjct 499 GAGASLEEAKTDIEATEAIDGDRSQLEETE#AVAAQEKVIPSVVIQPASN 547
|
| Canis familiaris |
Query 637 GEGVSLEEAKIGXXXXXXXXXXXXXXXXXX#XV-PQEKVIPSVVIEPASN 684
||| +|||+ # | | ||||||||||||||
Sbjct 653 GEGAGVEEARPDTEATQAVDGDRSQLEEAE#AVAPLEKVIPSVVIEPASN 701
|
[Site 2] FEDNFVPEIS336-VTTPSQNEVP
Ser336 Val
|
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Phe327 | Glu328 | Asp329 | Asn330 | Phe331 | Val332 | Pro333 | Glu334 | Ile335 | Ser336 |
|
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Val337 | Thr338 | Thr339 | Pro340 | Ser341 | Gln342 | Asn343 | Glu344 | Val345 | Pro346 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
PPLPKVTPTKELRQENIISFFEDNFVPEISVTTPSQNEVPEVKKEETLLDLDFDPFKPEV
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Macaca mulatta |
125.00 |
4 |
PREDICTED: amphiphysin isoform 3 |
| 2 |
Homo sapiens |
123.00 |
18 |
Amphiphysin (Stiff-Man syndrome with breast cancer |
| 3 |
Pan troglodytes |
123.00 |
6 |
PREDICTED: amphiphysin |
| 4 |
Canis familiaris |
123.00 |
2 |
PREDICTED: similar to Amphiphysin |
| 5 |
synthetic construct |
123.00 |
1 |
amphiphysin |
| 6 |
Bos taurus |
122.00 |
2 |
hypothetical protein LOC614722 |
| 7 |
Mus musculus |
116.00 |
4 |
amphiphysin |
| 8 |
Rattus norvegicus |
116.00 |
3 |
amphiphysin 1 |
| 9 |
Monodelphis domestica |
116.00 |
2 |
PREDICTED: similar to cytokine receptor common gam |
| 10 |
Gallus gallus |
110.00 |
1 |
amphiphysin (Stiff-Man syndrome with breast cancer |
| 11 |
Xenopus tropicalis |
109.00 |
3 |
Unknown (protein for MGC:122074) |
| 12 |
Xenopus laevis |
107.00 |
1 |
hypothetical protein LOC432150 |
| 13 |
Danio rerio |
73.20 |
1 |
amphiphysin |
| 14 |
Lampetra fluviatilis |
63.20 |
1 |
amphiphysin |
| 15 |
N/A |
59.70 |
1 |
A |
| 16 |
Tetraodon nigroviridis |
56.20 |
1 |
unnamed protein product |
Top-ranked sequences
| organism | matching |
|---|
| Macaca mulatta |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 366
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 366
|
| Homo sapiens |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 366
||||||||||||+|||||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 304 PPLPKVTPTKELQQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 363
|
| Pan troglodytes |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 366
||||||||||||+|||||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 407 PPLPKVTPTKELQQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 466
|
| Canis familiaris |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 366
||||||||||||+|||||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 323 PPLPKVTPTKELQQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 382
|
| synthetic construct |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 366
||||||||||||+|||||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 304 PPLPKVTPTKELQQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 363
|
| Bos taurus |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 366
||||||||||||+|||||||||||||||||#||||||||+|||||||||||||||||||+|
Sbjct 304 PPLPKVTPTKELQQENIISFFEDNFVPEIS#VTTPSQNEIPEVKKEETLLDLDFDPFKPDV 363
|
| Mus musculus |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 366
||||||||||||+|||||+||||||||||+#||||||||| ||||||||||||||||||+|
Sbjct 304 PPLPKVTPTKELKQENIINFFEDNFVPEIN#VTTPSQNEVLEVKKEETLLDLDFDPFKPDV 363
|
| Rattus norvegicus |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 366
||||||||||||+|||||+||||||||||+#||||||||| ||||||||||||||||||+|
Sbjct 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQNEVLEVKKEETLLDLDFDPFKPDV 363
|
| Monodelphis domestica |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 366
||||||||||||+|||||| ||||||||||#||||||||||| ||||+|||||||||||+|
Sbjct 304 PPLPKVTPTKELQQENIISLFEDNFVPEIS#VTTPSQNEVPEQKKEESLLDLDFDPFKPDV 363
|
| Gallus gallus |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 366
|||||+||||||+|||||+ |+|||||||+#||||||||+|| || |+|||||||||||||
Sbjct 304 PPLPKLTPTKELQQENIINLFDDNFVPEIN#VTTPSQNEIPETKKVESLLDLDFDPFKPEV 363
|
| Xenopus tropicalis |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPE 365
|||||+||+|||+||||||||||||||||+#|||||||| | ||||+||||||||||||
Sbjct 305 PPLPKLTPSKELQQENIISFFEDNFVPEIN#VTTPSQNEAVEEKKEESLLDLDFDPFKPE 363
|
| Xenopus laevis |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKP 364
|||||+||+|||+||||||||||||||||+#|||||||| | ||||+|||||||||||
Sbjct 309 PPLPKLTPSKELQQENIISFFEDNFVPEIN#VTTPSQNEAVEEKKEESLLDLDFDPFKP 366
|
| Danio rerio |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPE 365
|| ||||||+||+|| || |+ | ||||#||+| || | |+|||||||||||+
Sbjct 304 PPPPKVTPTRELQQEQIIDLFDGGF-PEIS#VTSPQPNERP----GESLLDLDFDPFKPD 357
|
| Lampetra fluviatilis |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPE 365
|| ||+||+||++|| | | |+|||||+ |# + |++ | | +|||+|||| ||+
Sbjct 303 PPPPKLTPSKEVQQEAIFSLFDDNFVPDFS#-SAPAE---AAKKDEGSLLDIDFDPLKPD 357
|
| N/A |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQ 342
|| || ||+||++|| |+| ||| ||||||#||||||
Sbjct 42 PPPPKHTPSKEVKQEQILSLFEDTFVPEIS#VTTPSQ 77
|
| Tetraodon nigroviridis |
Query 307 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQNEVPEVKKEETLLDLDFDPFKPEV 366
|| |||||+|+++ |||++ |+ |+||#||+|++ + | | +|||+| | | |
Sbjct 212 PPPPKVTPSKDMKAENIVNLFDAAAAPDIS#VTSPTEFDRPAV---SSLLDVDLDSFTSTV 268
|
[Site 3] GAESAQAEAE662-ELAATVPQEK
Glu662 Glu
|
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Gly653 | Ala654 | Glu655 | Ser656 | Ala657 | Gln658 | Ala659 | Glu660 | Ala661 | Glu662 |
|
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Glu663 | Leu664 | Ala665 | Ala666 | Thr667 | Val668 | Pro669 | Gln670 | Glu671 | Lys672 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
TLPAGEGVSLEEAKIGTETEGAESAQAEAEELAATVPQEKVIPSVVIEPASNHEEEGEHE
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Macaca mulatta |
77.40 |
3 |
PREDICTED: amphiphysin isoform 3 |
| 2 |
Homo sapiens |
68.90 |
8 |
amphiphysin isoform 1 |
| 3 |
synthetic construct |
68.90 |
1 |
amphiphysin |
| 4 |
Pan troglodytes |
66.20 |
1 |
PREDICTED: amphiphysin |
| 5 |
Bos taurus |
52.80 |
1 |
hypothetical protein LOC614722 |
| 6 |
Canis familiaris |
48.90 |
1 |
PREDICTED: similar to Amphiphysin |
| 7 |
Mus musculus |
48.50 |
3 |
amphiphysin |
| 8 |
Rattus norvegicus |
48.10 |
1 |
amphiphysin 1 |
| 9 |
Monodelphis domestica |
42.00 |
1 |
PREDICTED: similar to amphiphysin I variant CT2 |
| 10 |
Xenopus laevis |
36.20 |
1 |
hypothetical protein LOC432150 |
| 11 |
Gallus gallus |
36.20 |
1 |
amphiphysin (Stiff-Man syndrome with breast cancer |
Top-ranked sequences
| organism | matching |
|---|
| Macaca mulatta |
Query 633 TLPAGEGVSLEEAKIGXXXXXXXXXXXXXX#XXXXXVPQEKVIPSVVIEPASNHEEEGEHE 692
|||||||||||||||| # |||||||||||||||||||||||||
Sbjct 633 TLPAGEGVSLEEAKIGTETEGAESAQAEAE#ELAATVPQEKVIPSVVIEPASNHEEEGEHE 692
|
| Homo sapiens |
Query 633 TLPAGEGVSLEEAKIGXXXXXXXXXXXXXX#XXXXX-VPQEKVIPSVVIEPASNHEEEGEH 691
|+|||||||||||||| # |||||||||||||||||||||||+
Sbjct 498 TVPAGEGVSLEEAKIGTETTEGAESAQPEA#EELEATVPQEKVIPSVVIEPASNHEEEGEN 557
Query 692 E 692
|
Query 692 E 692
|
| synthetic construct |
Query 633 TLPAGEGVSLEEAKIGXXXXXXXXXXXXXX#XXXXX-VPQEKVIPSVVIEPASNHEEEGEH 691
|+|||||||||||||| # |||||||||||||||||||||||+
Sbjct 498 TVPAGEGVSLEEAKIGTETTEGAESAQPEA#EELEATVPQEKVIPSVVIEPASNHEEEGEN 557
Query 692 E 692
|
Query 692 E 692
|
| Pan troglodytes |
Query 633 TLPAGEGVSLEEAKIGXXXXXXXXXXXXXX#XXXXX-VPQEKVIPSVVIEPASNHEEEGEH 691
|+|||||||||||||| # ||||||||||||||||||| |||+
Sbjct 733 TVPAGEGVSLEEAKIGTETTEGAESAQPEA#EELEVTVPQEKVIPSVVIEPASNHEGEGEN 792
Query 692 E 692
|
Query 692 E 692
|
| Bos taurus |
Query 634 LPAGEGVSLEEAKIGXXXXXXXXXXXXXX#XXXXXVP-QEKVIPSVVIEPASNHEEEGEHE 692
|||| | |||||| # | ||||||||||+||||+| |||||
Sbjct 496 LPAGAGASLEEAKTDIEATEAIDGDRSQL#EETEAVAAQEKVIPSVVIQPASNNEGEGEHE 555
|
| Canis familiaris |
Query 634 LPAGEGVSLEEAKIGXXXXXXXXXXXXXX#XXXXXV-PQEKVIPSVVIEPASNHEEEGEHE 692
|| ||| +|||+ # | | ||||||||||||||+| ||+||
Sbjct 650 LPPGEGAGVEEARPDTEATQAVDGDRSQL#EEAEAVAPLEKVIPSVVIEPASNNEGEGDHE 709
|
| Mus musculus |
Query 634 LPAGEGVSLEEAKI-GXXXXXXXXXXXXXX#XXXXXVPQEKVIPSVVIEPASNHEEEGEHE 692
|||||| | | ||| | # || |||||||||||||| ||||+
Sbjct 493 LPAGEGGSPEGAKIDGESTELAISESPQPV#EPEAGAPQ--VIPSVVIEPASNHEGEGEHQ 550
|
| Rattus norvegicus |
Query 634 LPAGEGVSLEEAKIGXXXXXXXXXXXXXX#XXXXX-VPQEKVIPSVVIEPASNHEEEGEHE 692
|||||| | | ||| # |||||||||||||||||| | ||+
Sbjct 489 LPAGEGESPEGAKIDVESTELASSESPQA#AELEAGAPQEKVIPSVVIEPASNHEGE-EHQ 547
|
| Monodelphis domestica |
Query 670 QEKVIPSVVIEPASNHEEEGEHE 692
||||||||||||||||| | | |
Sbjct 79 QEKVIPSVVIEPASNHEGEDEQE 101
|
| Xenopus laevis |
Query 669 PQEKVIPSVVIEPASNHEEEGEHE 692
|+ +|||||||||||||+| + +
Sbjct 524 PEITIIPSVVIEPASNHEDEHDDD 547
|
| Gallus gallus |
Query 668 VPQEKV--IPSVVIEPASNHEEEGE 690
| |||| |||||||||||+| |||
Sbjct 525 VSQEKVSSIPSVVIEPASNNEGEGE 549
|
