CaMPDB :: Substrate

XSB2134 : amphiphysin [Rattus norvegicus]

This entry is computationally expanded from SB0093

* Basic Information

Organism	Rattus norvegicus (Norway rat)
Protein Names	amphiphysin; amphiphysin 1
Gene Names	Amph; Amph1; amphiphysin
Gene Locus	17q11; chromosome 17
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_071553	NM_022217	60668	O08838	N/A	N/A	N/A	rno:60668

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 683 aa

Average Mass: 74.878 kDa

Monoisotopic Mass: 74.832 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
BAR 1.	13	233	288.1	1.9e-83
Drf_FH1 1.	260	406	-44.9	8.1
--- cleavage 333 (inside Drf_FH1 260..406) ---
--- cleavage 392 (inside Drf_FH1 260..406) ---
--- cleavage 377 (inside Drf_FH1 260..406) ---
DUF2510 1.	416	445	-17.3	9.5
SH3_1 1.	613	682	21.5	0.00032

3. Sequence Information

Fasta Sequence: XSB2134.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 2VJ0 (X-ray; 160 A; Q=324-330)

* Cleavage Information

3 [sites]

Cleavage sites (±10aa)

[Site 1] FEDNFVPEIN³³³-VTTPSQNEVL

Asn³³³ Val

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Phe³²⁴	Glu³²⁵	Asp³²⁶	Asn³²⁷	Phe³²⁸	Val³²⁹	Pro³³⁰	Glu³³¹	Ile³³²	Asn³³³

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Val³³⁴	Thr³³⁵	Thr³³⁶	Pro³³⁷	Ser³³⁸	Gln³³⁹	Asn³⁴⁰	Glu³⁴¹	Val³⁴²	Leu³⁴³

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
PPLPKVTPTKELQQENIINFFEDNFVPEINVTTPSQNEVLEVKKEETLLDLDFDPFKPDV

Summary

#	organism	max score	hits	top seq
1	Rattus norvegicus	80.50	3	amphiphysin 1
2	Mus musculus	79.00	4	amphiphysin
3	Homo sapiens	76.60	17	amphiphysin isoform 1
4	Pan troglodytes	76.60	6	PREDICTED: amphiphysin
5	Canis familiaris	76.60	2	PREDICTED: similar to Amphiphysin
6	Bos taurus	76.60	2	hypothetical protein LOC614722
7	synthetic construct	76.60	1	amphiphysin
8	Xenopus tropicalis	75.90	3	Unknown (protein for MGC:122074)
9	Gallus gallus	75.90	1	amphiphysin (Stiff-Man syndrome with breast cancer
10	Xenopus laevis	75.90	1	hypothetical protein LOC432150
11	Macaca mulatta	75.10	4	PREDICTED: amphiphysin isoform 2
12	Monodelphis domestica	74.30	2	PREDICTED: similar to cytokine receptor common gam
13	N/A	57.00	1	A
14	Danio rerio	50.40	1	amphiphysin
15	Tetraodon nigroviridis	46.60	1	unnamed protein product

Top-ranked sequences

organism	matching
Rattus norvegicus	Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQN 340 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQN 340
Mus musculus	Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQN 340 \|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| Sbjct 304 PPLPKVTPTKELKQENIINFFEDNFVPEIN#VTTPSQN 340
Homo sapiens	Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQN 340 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|+#\|\|\|\|\|\|\| Sbjct 304 PPLPKVTPTKELQQENIISFFEDNFVPEIS#VTTPSQN 340
Pan troglodytes	Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQN 340 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|+#\|\|\|\|\|\|\| Sbjct 407 PPLPKVTPTKELQQENIISFFEDNFVPEIS#VTTPSQN 443
Canis familiaris	Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQN 340 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|+#\|\|\|\|\|\|\| Sbjct 323 PPLPKVTPTKELQQENIISFFEDNFVPEIS#VTTPSQN 359
Bos taurus	Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQN 340 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|+#\|\|\|\|\|\|\| Sbjct 304 PPLPKVTPTKELQQENIISFFEDNFVPEIS#VTTPSQN 340
synthetic construct	Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQN 340 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|+#\|\|\|\|\|\|\| Sbjct 304 PPLPKVTPTKELQQENIISFFEDNFVPEIS#VTTPSQN 340
Xenopus tropicalis	Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQN 340 \|\|\|\|\|+\|\|+\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| Sbjct 305 PPLPKLTPSKELQQENIISFFEDNFVPEIN#VTTPSQN 341
Gallus gallus	Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQN 340 \|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| Sbjct 304 PPLPKLTPTKELQQENIINLFDDNFVPEIN#VTTPSQN 340
Xenopus laevis	Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQN 340 \|\|\|\|\|+\|\|+\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\| Sbjct 309 PPLPKLTPSKELQQENIISFFEDNFVPEIN#VTTPSQN 345
Macaca mulatta	Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQN 340 \|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|+#\|\|\|\|\|\|\| Sbjct 304 PPLPKVTPTKELRQENIISFFEDNFVPEIS#VTTPSQN 340
Monodelphis domestica	Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQN 340 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+ \|\|\|\|\|\|\|\|\|+#\|\|\|\|\|\|\| Sbjct 304 PPLPKVTPTKELQQENIISLFEDNFVPEIS#VTTPSQN 340
N/A	Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQ 339 \|\| \|\| \|\|+\|\|++\|\| \|++ \|\|\| \|\|\|\|\|+#\|\|\|\|\|\| Sbjct 42 PPPPKHTPSKEVKQEQILSLFEDTFVPEIS#VTTPSQ 77
Danio rerio	Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQN 340 \|\| \|\|\|\|\|\|+\|\|\|\|\| \|\|+ \|+ \| \|\|\|+#\|\|+\| \| Sbjct 304 PPPPKVTPTRELQQEQIIDLFDGGF-PEIS#VTSPQPN 339
Tetraodon nigroviridis	Query 304 PPLPKVTPTKELQQENIINFFEDNFVPEIN#VTTPSQ 339 \|\| \|\|\|\|\|+\|+++ \|\|\|+\| \|+ \|+\|+#\|\|+\|++ Sbjct 212 PPPPKVTPSKDMKAENIVNLFDAAAAPDIS#VTSPTE 247

[Site 2] DLWTTSTDLV³⁹²-QPASGGSFND

Val³⁹² Gln

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Asp³⁸³	Leu³⁸⁴	Trp³⁸⁵	Thr³⁸⁶	Thr³⁸⁷	Ser³⁸⁸	Thr³⁸⁹	Asp³⁹⁰	Leu³⁹¹	Val³⁹²

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Gln³⁹³	Pro³⁹⁴	Ala³⁹⁵	Ser³⁹⁶	Gly³⁹⁷	Gly³⁹⁸	Ser³⁹⁹	Phe⁴⁰⁰	Asn⁴⁰¹	Asp⁴⁰²

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
VTPAGSAAATHSPMSQTLPWDLWTTSTDLVQPASGGSFNDFTQPQDTSLFTMQTDQNMAE

Summary

#	organism	max score	hits	top seq
1	Rattus norvegicus	127.00	1	amphiphysin 1
2	Mus musculus	122.00	2	amphiphysin
3	Homo sapiens	116.00	11	amphiphysin isoform 1
4	synthetic construct	116.00	1	amphiphysin
5	Macaca mulatta	112.00	3	PREDICTED: amphiphysin isoform 2
6	Bos taurus	104.00	2	hypothetical protein LOC614722
7	Monodelphis domestica	90.90	1	PREDICTED: similar to cytokine receptor common gam
8	Gallus gallus	73.60	1	amphiphysin (Stiff-Man syndrome with breast cancer
9	Xenopus tropicalis	70.90	1	Unknown (protein for MGC:122074)
10	Xenopus laevis	61.60	1	hypothetical protein LOC432150
11	Pan troglodytes	54.70	1	PREDICTED: amphiphysin
12	Canis familiaris	52.40	1	PREDICTED: similar to Amphiphysin
13	Danio rerio	40.00	1	amphiphysin

Top-ranked sequences

organism	matching
Rattus norvegicus	Query 363 VTPAGSAAATHSPMSQTLPWDLWTTSTDLV#QPASGGSFNDFTQPQDTSLFTMQTDQNMAE 422 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 363 VTPAGSAAATHSPMSQTLPWDLWTTSTDLV#QPASGGSFNDFTQPQDTSLFTMQTDQNMAE 422
Mus musculus	Query 363 VTPAGSAAATHSPMSQTLPWDLWTTSTDLV#QPASGGSFNDFTQPQDTSLFTMQTDQNMAE 422 \| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 363 VAPAGSAAATHSPMSQTLPWDLWTTSTDLV#QPASGGSFNDFTQAQDTSLFTMQTDQNMAE 422
Homo sapiens	Query 363 VTPAGSAAATHSPMSQTLPWDLWTTSTDLV#QPASGGSFNDFTQPQDTSLFTMQTDQNM 420 \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\| Sbjct 363 VTPAGSAGVTHSPMSQTLPWDLWTTSTDLV#QPASGGSFNGFTQPQDTSLFTMQTDQSM 420
synthetic construct	Query 363 VTPAGSAAATHSPMSQTLPWDLWTTSTDLV#QPASGGSFNDFTQPQDTSLFTMQTDQNM 420 \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\| Sbjct 363 VTPAGSAGVTHSPMSQTLPWDLWTTSTDLV#QPASGGSFNGFTQPQDTSLFTMQTDQSM 420
Macaca mulatta	Query 363 VTPAGSAAATHSPMSQTLPWDLWTTSTDLV#QPASGGSFNDFTQPQDTSLFTMQTDQNM 420 \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|#\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\| \|\|\|\|\|+\| Sbjct 363 VTPAGSAGVTHSPMSQTLPWDLWTTSADLV#QPASGGSFNGFTQPQDTSLFAMQTDQSM 420
Bos taurus	Query 363 VTPAGSAAATHSPMSQTLPWDLWTTSTDLV#QPASGGSFNDFTQPQDTSLFTMQTDQNM 420 \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\| \|\| \|\|\|\|\|\|\|\|\| \|\|+\| Sbjct 363 VTPAGSAGVTHSPMSQTLPWDLWTTSTDLV#QPASGGSFNGFT--QDTSLFTMQADQSM 418
Monodelphis domestica	Query 363 VTPAGSAAATHSPMSQTLPWDLWTTSTDLV#QPASGGSFNDFTQPQDTSLFTMQTDQ 418 \|\|\| \|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|++\|\|#\|\|\|\| \|+\|\| \|\|\|\|\|\|\|\|\|\| \| \| Sbjct 363 VTPVGSAGIAPSPMSQTLPWDLWTTSSELV#QPASSGTFNGFTQPQDTSLFDMPASQ 418
Gallus gallus	Query 368 SAAATHSPMSQTLPWDLWTTSTDLV#QPASGGSFNDFTQPQDTSLFTMQTDQNMAE 422 \| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+++\|\|#\|\|\|\| +\|\| \| \|\|\|+ \| +\|+++\|+ \| Sbjct 365 STGVTHSPMSQTLPWDLWTTTSELV#QPASSTAFNGFA--QDTTAFAVQSNENVTE 417
Xenopus tropicalis	Query 372 THSPMSQTLPWDLWTTSTDLV#QPASGGSFNDFTQPQDTS-LFTMQTDQN 419 +\|\|\|+\|\|\|\|\|\|\|\|\|\|\|+ ++\|#\|\|\|\| \|+\|\| \|\|\|\| ++ \|\|\|+ +\|\| Sbjct 372 SHSPLSQTLPWDLWTTNNEVV#QPASTGAFNGFTQPDASAPLFTLPLEQN 420
Xenopus laevis	Query 372 THSPMSQTLPWDLWT-------TSTDLV#QPASGGSFNDFTQPQDTS-LFTMQTDQN 419 +\|\|\|+\|\|\|\|\|\|\|\|\|\| \|+ ++\|#\|\|\|\| \| \|\| \|\|\|\| ++ \|\|\|+ +++\| Sbjct 376 SHSPISQTLPWDLWTCFCPSTQTNNEVV#QPASTGVFNGFTQPDASAPLFTLPSEKN 431
Pan troglodytes	Query 363 VTPAGSAAATHSPMSQTLPWDLWTTSTDLV#QP 394 \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\| Sbjct 466 VTPAGSAGVTHSPMSQTLPWDLWTTSTDLV#QP 497 Query 378 QTLPWDLWTTSTDLV#QPASGGSFNDFTQPQDTSLFTMQTDQNM 420 \| + \|\|+ + #\| \|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|++ Sbjct 656 QKIEDSLWS-GVEAC#QKASGGSFNGFTQPQDTSLFTMQTDQSV 697
Canis familiaris	Query 363 VTPAGSAAATHSPMSQTLPWDLWTTSTDLV#QP 394 \| \| \|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\| Sbjct 382 VAPVGSVGVTHSPMSQTLPWDLWTTSTDLV#QP 413 Query 378 QTLPWDLWTTSTDLV#QPASGGSFNDFTQPQDTSLFTMQTDQNM 420 \| + +\| + #+ \|\|\|\|+\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\| Sbjct 572 QKIEDSVWA-GVETC#EKASGGTFNGFTQPQDTSLFTMQTDQSM 613
Danio rerio	Query 364 TPAGSAAATHSPMSQTLPWDLWTTSTDLV#QPASGGSFNDFT 404 \|\| \| \| \|\|+\|\|\|\|\|\|\|\|\|\| \| #\|\|\| + \|\| Sbjct 360 TPIGQ---TQSPVSQTLPWDLWT--GDAA#QPAQPATDAGFT 395

[Site 3] SAAATHSPMS³⁷⁷-QTLPWDLWTT

Ser³⁷⁷ Gln

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Ser³⁶⁸	Ala³⁶⁹	Ala³⁷⁰	Ala³⁷¹	Thr³⁷²	His³⁷³	Ser³⁷⁴	Pro³⁷⁵	Met³⁷⁶	Ser³⁷⁷

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Gln³⁷⁸	Thr³⁷⁹	Leu³⁸⁰	Pro³⁸¹	Trp³⁸²	Asp³⁸³	Leu³⁸⁴	Trp³⁸⁵	Thr³⁸⁶	Thr³⁸⁷

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
EETLLDLDFDPFKPDVTPAGSAAATHSPMSQTLPWDLWTTSTDLVQPASGGSFNDFTQPQ

Summary

#	organism	max score	hits	top seq
1	Rattus norvegicus	99.40	1	amphiphysin 1
2	Mus musculus	94.40	2	amphiphysin
3	Homo sapiens	93.60	8	Amphiphysin (Stiff-Man syndrome with breast cancer
4	synthetic construct	93.60	1	amphiphysin
5	Macaca mulatta	91.70	3	PREDICTED: amphiphysin isoform 2
6	Bos taurus	89.00	2	hypothetical protein LOC614722
7	Monodelphis domestica	78.20	1	PREDICTED: similar to cytokine receptor common gam
8	Xenopus tropicalis	64.70	1	Unknown (protein for MGC:122074)
9	Canis familiaris	64.30	1	PREDICTED: similar to Amphiphysin
10	Gallus gallus	63.50	1	amphiphysin (Stiff-Man syndrome with breast cancer
11	Xenopus laevis	56.20	1	hypothetical protein LOC432150
12	Danio rerio	40.00	1	amphiphysin
13	Pan troglodytes	32.30	1	PREDICTED: amphiphysin

Top-ranked sequences

organism	matching
Rattus norvegicus	Query 348 EETXXXXXXXXXXXXVTPAGSAAATHSPMS#QTLPWDLWTTSTDLVQPASGGSFNDFTQPQ 407 \|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 348 EETLLDLDFDPFKPDVTPAGSAAATHSPMS#QTLPWDLWTTSTDLVQPASGGSFNDFTQPQ 407
Mus musculus	Query 348 EETXXXXXXXXXXXXVTPAGSAAATHSPMS#QTLPWDLWTTSTDLVQPASGGSFNDFTQPQ 407 \|\|\| \| \|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \| Sbjct 348 EETLLDLDFDPFKPDVAPAGSAAATHSPMS#QTLPWDLWTTSTDLVQPASGGSFNDFTQAQ 407
Homo sapiens	Query 348 EETXXXXXXXXXXXXVTPAGSAAATHSPMS#QTLPWDLWTTSTDLVQPASGGSFNDFTQPQ 407 \|\|\| \|\|\|\|\|\|\| \|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\| Sbjct 348 EETLLDLDFDPFKPEVTPAGSAGVTHSPMS#QTLPWDLWTTSTDLVQPASGGSFNGFTQPQ 407
synthetic construct	Query 348 EETXXXXXXXXXXXXVTPAGSAAATHSPMS#QTLPWDLWTTSTDLVQPASGGSFNDFTQPQ 407 \|\|\| \|\|\|\|\|\|\| \|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\| Sbjct 348 EETLLDLDFDPFKPEVTPAGSAGVTHSPMS#QTLPWDLWTTSTDLVQPASGGSFNGFTQPQ 407
Macaca mulatta	Query 348 EETXXXXXXXXXXXXVTPAGSAAATHSPMS#QTLPWDLWTTSTDLVQPASGGSFNDFTQPQ 407 \|\|\| \|\|\|\|\|\|\| \|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\| Sbjct 348 EETLLDLDFDPFKPEVTPAGSAGVTHSPMS#QTLPWDLWTTSADLVQPASGGSFNGFTQPQ 407
Bos taurus	Query 348 EETXXXXXXXXXXXXVTPAGSAAATHSPMS#QTLPWDLWTTSTDLVQPASGGSFNDFTQ 405 \|\|\| \|\|\|\|\|\|\| \|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\| Sbjct 348 EETLLDLDFDPFKPDVTPAGSAGVTHSPMS#QTLPWDLWTTSTDLVQPASGGSFNGFTQ 405
Monodelphis domestica	Query 363 VTPAGSAAATHSPMS#QTLPWDLWTTSTDLVQPASGGSFNDFTQPQ 407 \|\|\| \|\|\| \|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|++\|\|\|\|\|\| \|+\|\| \|\|\|\|\| Sbjct 363 VTPVGSAGIAPSPMS#QTLPWDLWTTSSELVQPASSGTFNGFTQPQ 407
Xenopus tropicalis	Query 372 THSPMS#QTLPWDLWTTSTDLVQPASGGSFNDFTQP 406 +\|\|\|+\|#\|\|\|\|\|\|\|\|\|\|+ ++\|\|\|\|\| \|+\|\| \|\|\|\| Sbjct 372 SHSPLS#QTLPWDLWTTNNEVVQPASTGAFNGFTQP 406
Canis familiaris	Query 348 EETXXXXXXXXXXXXVTPAGSAAATHSPMS#QTLPWDLWTTSTDLVQP 394 \|\|\| \| \| \|\| \|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 367 EETLLDLDFDPFKPEVAPVGSVGVTHSPMS#QTLPWDLWTTSTDLVQP 413
Gallus gallus	Query 368 SAAATHSPMS#QTLPWDLWTTSTDLVQPASGGSFNDFTQ 405 \| \|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|+++\|\|\|\|\|\| +\|\| \| \| Sbjct 365 STGVTHSPMS#QTLPWDLWTTTSELVQPASSTAFNGFAQ 402
Xenopus laevis	Query 372 THSPMS#QTLPWDLWT-------TSTDLVQPASGGSFNDFTQP 406 +\|\|\|+\|#\|\|\|\|\|\|\|\|\| \|+ ++\|\|\|\|\| \| \|\| \|\|\|\| Sbjct 376 SHSPIS#QTLPWDLWTCFCPSTQTNNEVVQPASTGVFNGFTQP 417
Danio rerio	Query 364 TPAGSAAATHSPMS#QTLPWDLWTTSTDLVQPASGGSFNDFT 404 \|\| \| \| \|\|+\|#\|\|\|\|\|\|\|\|\| \| \|\|\| + \|\| Sbjct 360 TPIGQ---TQSPVS#QTLPWDLWT--GDAAQPAQPATDAGFT 395
Pan troglodytes	Query 348 EETXXXXXXXXXXXXVTPAGSAAATHSPMS#QTLPWDLWTTSTDLVQP 394 \|\|\| \|\|\|\|\|\|\| \|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 451 EETLLDLDFDPFKPEVTPAGSAGVTHSPMS#QTLPWDLWTTSTDLVQP 497 Query 378 QTLPWDLWTTSTDLVQPASGGSFNDFTQPQ 407 \| + \|\|+ + \| \|\|\|\|\|\|\| \|\|\|\|\| Sbjct 656 QKIEDSLWS-GVEACQKASGGSFNGFTQPQ 684

* References

[PubMed ID: 19122684] Nakanishi A, Abe T, Watanabe M, Takei K, Yamada H, Dynamin 2 cooperates with amphiphysin 1 in phagocytosis in sertoli cells. Acta Med Okayama. 2008 Dec;62(6):385-91.

» More (9) « Hide Below

[PubMed ID: 18344231] ... Craft GE, Graham ME, Bache N, Larsen MR, Robinson PJ, The in vivo phosphorylation sites in multiple isoforms of amphiphysin I from rat brain nerve terminals. Mol Cell Proteomics. 2008 Jun;7(6):1146-61. Epub 2008 Mar 14.

[PubMed ID: 17855509] ... Yamada H, Ohashi E, Abe T, Kusumi N, Li SA, Yoshida Y, Watanabe M, Tomizawa K, Kashiwakura Y, Kumon H, Matsui H, Takei K, Amphiphysin 1 is important for actin polymerization during phagocytosis. Mol Biol Cell. 2007 Nov;18(11):4669-80. Epub 2007 Sep 12.

[PubMed ID: 15953416] ... Jockusch WJ, Praefcke GJ, McMahon HT, Lagnado L, Clathrin-dependent and clathrin-independent retrieval of synaptic vesicles in retinal bipolar cells. Neuron. 2005 Jun 16;46(6):869-78.

[PubMed ID: 15821731] ... Irie F, Okuno M, Pasquale EB, Yamaguchi Y, EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1. Nat Cell Biol. 2005 May;7(5):501-9. Epub 2005 Apr 10.

[PubMed ID: 10567358] ... Rosenthal JA, Chen H, Slepnev VI, Pellegrini L, Salcini AE, Di Fiore PP, De Camilli P, The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. J Biol Chem. 1999 Nov 26;274(48):33959-65.

[PubMed ID: 10430869] ... Traub LM, Downs MA, Westrich JL, Fremont DH, Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8907-12.

[PubMed ID: 9694653] ... Slepnev VI, Ochoa GC, Butler MH, Grabs D, De Camilli P, Role of phosphorylation in regulation of the assembly of endocytic coat complexes. Science. 1998 Aug 7;281(5378):821-4.

[PubMed ID: 9341169] ... Micheva KD, Kay BK, McPherson PS, Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin. J Biol Chem. 1997 Oct 24;272(43):27239-45.

[PubMed ID: 9348539] ... Wigge P, Kohler K, Vallis Y, Doyle CA, Owen D, Hunt SP, McMahon HT, Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis. Mol Biol Cell. 1997 Oct;8(10):2003-15.