XSB2143 : insulin-like growth factor-binding protein-2 [Ovis aries]
[ CaMP Format ]
This entry is computationally expanded from SB0097
* Basic Information
| Organism | Ovis aries (sheep) |
| Protein Names | Insulin-like growth factor-binding protein 2; IGF-binding protein 2; IGFBP-2; IBP-2; insulin-like growth factor-binding protein-2 |
| Gene Names | IGFBP-2; IGFBP2; insulin-like growth factor-binding protein-2 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 317 aa
Average Mass: 34.189 kDa
Monoisotopic Mass: 34.167 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| IGFBP 1. | 39 | 108 | 88.7 | 2.1e-23 |
| Protamine_3 1. | 169 | 212 | -5.3 | 9.9 |
| --- cleavage 191 (inside Protamine_3 169..212) --- |
| Thyroglobulin_1 1. | 219 | 298 | 150.4 | 5.5e-42 |
3. Sequence Information
Fasta Sequence: XSB2143.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] VFREKVTEQH191-RQMGKGGKHH
His191 
Arg
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Val182 | Phe183 | Arg184 | Glu185 | Lys186 | Val187 | Thr188 | Glu189 | Gln190 | His191 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Arg192 | Gln193 | Met194 | Gly195 | Lys196 | Gly197 | Gly198 | Lys199 | His200 | His201 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
MGGGGGAGRKPLKFRMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQ
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Ovis aries |
113.00 |
1 |
insulin-like growth factor-binding protein-2 |
| 2 |
Homo sapiens |
107.00 |
5 |
unnamed protein product |
| 3 |
N/A |
107.00 |
2 |
- |
| 4 |
Sus scrofa |
107.00 |
1 |
insulin-like growth factor binding protein 2 |
| 5 |
Bubalus bubalis |
107.00 |
1 |
insulin-like growth factor binding protein-2 |
| 6 |
Pan troglodytes |
107.00 |
1 |
PREDICTED: insulin-like growth factor binding prot |
| 7 |
synthetic construct |
107.00 |
1 |
insulin-like growth factor binding protein 2, 36kD |
| 8 |
Bos taurus |
107.00 |
1 |
insulin-like growth factor binding protein 2, 36kD |
| 9 |
Canis familiaris |
106.00 |
1 |
PREDICTED: similar to Insulin-like growth factor b |
| 10 |
Macaca mulatta |
105.00 |
1 |
PREDICTED: insulin-like growth factor binding prot |
| 11 |
Mus musculus |
93.20 |
3 |
IBP2_MOUSE Insulin-like growth factor-binding prot |
| 12 |
Rattus norvegicus |
90.50 |
3 |
IBP2_RAT Insulin-like growth factor-binding protei |
| 13 |
Equus caballus |
88.60 |
1 |
insulin-like growth factor binding protein-2 |
| 14 |
Monodelphis domestica |
73.20 |
1 |
PREDICTED: similar to Insulin-like growth factor-b |
| 15 |
Gallus gallus |
69.70 |
3 |
insulin-like growth factor binding protein 2 |
| 16 |
Coturnix coturnix |
61.20 |
1 |
AF260701_1 IGF binding protein 2 |
Top-ranked sequences
| organism | matching |
|---|
| Ovis aries |
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
|
| Homo sapiens |
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
||||| |||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 181 RKPLKSGMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 232
|
| N/A |
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
||||| |||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 181 RKPLKSGMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 232
|
| Sus scrofa |
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
||||| |||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 169 RKPLKSGMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 220
|
| Bubalus bubalis |
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
||||| |||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 44 RKPLKSGMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 95
|
| Pan troglodytes |
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
||||| |||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 299 RKPLKSGMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 350
|
| synthetic construct |
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
||||| |||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 181 RKPLKSGMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 232
|
| Bos taurus |
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
||||| |||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 170 RKPLKSGMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
|
| Canis familiaris |
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
||||| |||||||||||||||#|||||||||||||+||||||||||||||||
Sbjct 124 RKPLKSGMKELAVFREKVTEQH#RQMGKGGKHHLGLDEPKKLRPPPARTPCQQ 175
|
| Macaca mulatta |
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
||||| ||||||||||| |||#||||||||||||||||||||||||||||||
Sbjct 179 RKPLKSGMKELAVFREKVAEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 230
|
| Mus musculus |
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
||||| ||||||||||| |||#|||||| | || ||||||||||||||||||
Sbjct 159 RKPLKSGMKELAVFREKVNEQH#RQMGKGAK-HLSLEEPKKLRPPPARTPCQQ 209
|
| Rattus norvegicus |
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
||| | ||||||||||| |||#|||||| | || ||||||||||||||||||
Sbjct 158 RKPPKSGMKELAVFREKVNEQH#RQMGKGAK-HLSLEEPKKLRPPPARTPCQQ 208
|
| Equus caballus |
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGK-HHLGLEEPKKLRPPPARTPCQQ 221
||||| ||||||+||||+ ||#||||+||| ||+ |||||||||| |||||||
Sbjct 2 RKPLKSGMKELAVYREKVSGQH#RQMGRGGKHHHVVLEEPKKLRPPSARTPCQQ 54
|
| Monodelphis domestica |
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
||| | |||||| |||| ||#||+|| || |+ ||||||| ||||||
Sbjct 172 RKPHKSGMKELAVIREKVIGQH#RQLGKVNMHHHIHEDTKKLRPPPTRTPCQQ 223
|
| Gallus gallus |
Query 170 RKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
||||| |||+|| |||| || #||||| || | |+ || | | ||||||
Sbjct 61 RKPLKTGMKEMAVMREKVNEQQ#RQMGKVGKAHHNHEDSKKSRMPTGRTPCQQ 112
|
| Coturnix coturnix |
Query 177 MKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
|||+|| |||| || #||||| || | |+ || | | ||||||
Sbjct 1 MKEMAVMREKVNEQQ#RQMGKVGKAHHNHEDSKKSRMPTGRTPCQQ 45
|
* References
[PubMed ID: 1381182] Delhanty PJ, Han VK, The characterization and expression of ovine insulin-like growth factor-binding protein-2. J Mol Endocrinol. 1992 Aug;9(1):31-8.
