XSB2146 : insulin-like growth factor binding protein 2 [Mus musculus]
[ CaMP Format ]
This entry is computationally expanded from SB0097
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | Insulin-like growth factor-binding protein 2; IGF-binding protein 2; IGFBP-2; IBP-2; insulin-like growth factor binding protein 2 |
| Gene Names | Igfbp2; Igfbp-2; insulin-like growth factor binding protein 2 |
| Gene Locus | 1 36.1 cM; chromosome 1 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_032368 | NM_008342 | 16008 | IBP2_MOUSE | N/A | N/A | N/A | mmu:16008 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 305 aa
Average Mass: 32.847 kDa
Monoisotopic Mass: 32.825 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| IGFBP 1. | 40 | 100 | 110.1 | 7.4e-30 |
| --- cleavage 180 --- | ||||
| Thyroglobulin_1 1. | 207 | 286 | 147.9 | 3.1e-41 |
3. Sequence Information
Fasta Sequence: XSB2146.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] VFREKVNEQH180-RQMGKGAKHL
His180 
Arg
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val171 | Phe172 | Arg173 | Glu174 | Lys175 | Val176 | Asn177 | Glu178 | Gln179 | His180 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Arg181 | Gln182 | Met183 | Gly184 | Lys185 | Gly186 | Ala187 | Lys188 | His189 | Leu190 |
Sequence conservation (by blast)
* References
[PubMed ID: 19142966] Diehl D, Hessel E, Oesterle D, Renner-Muller I, Elmlinger M, Langhammer M, Gottlicher M, Wolf E, Lahm H, Hoeflich A, IGFBP-2 overexpression reduces the appearance of dysplastic aberrant crypt foci and inhibits growth of adenomas in chemically induced colorectal carcinogenesis. Int J Cancer. 2009 May 1;124(9):2220-5.