XSB2148 : insulin-like growth factor binding protein-2 [Mus musculus]
[ CaMP Format ]
This entry is computationally expanded from SB0097
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | Insulin-like growth factor-binding protein 2; IGF-binding protein 2; IGFBP-2; IBP-2; insulin-like growth factor binding protein-2 |
| Gene Names | IGFBP-2; Igfbp-2 |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 305 aa
Average Mass: 32.762 kDa
Monoisotopic Mass: 32.740 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| IGFBP 1. | 40 | 100 | 109.2 | 1.4e-29 |
| --- cleavage 180 --- |
| Thyroglobulin_1 1. | 207 | 286 | 147.9 | 3.1e-41 |
3. Sequence Information
Fasta Sequence: XSB2148.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] VFREKVNEQH180-RQMGKGAKHL
His180 
Arg
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Val171 | Phe172 | Arg173 | Glu174 | Lys175 | Val176 | Asn177 | Glu178 | Gln179 | His180 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Arg181 | Gln182 | Met183 | Gly184 | Lys185 | Gly186 | Ala187 | Lys188 | His189 | Leu190 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
LGGGSSAGRKPLKSGMKELAVFREKVNEQHRQMGKGAKHLSLEEPKKLRPPPARTPCQQE
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Mus musculus |
125.00 |
3 |
IBP2_MOUSE Insulin-like growth factor-binding prot |
| 2 |
N/A |
125.00 |
2 |
- |
| 3 |
Rattus norvegicus |
119.00 |
3 |
insulin-like growth factor binding protein 2 |
| 4 |
Homo sapiens |
114.00 |
5 |
unnamed protein product |
| 5 |
Pan troglodytes |
114.00 |
1 |
PREDICTED: insulin-like growth factor binding prot |
| 6 |
synthetic construct |
114.00 |
1 |
insulin-like growth factor binding protein 2, 36kD |
| 7 |
Macaca mulatta |
113.00 |
1 |
PREDICTED: insulin-like growth factor binding prot |
| 8 |
Bubalus bubalis |
112.00 |
1 |
insulin-like growth factor binding protein-2 |
| 9 |
Bos taurus |
112.00 |
1 |
insulin-like growth factor binding protein 2, 36kD |
| 10 |
Canis familiaris |
111.00 |
1 |
PREDICTED: similar to Insulin-like growth factor b |
| 11 |
Sus scrofa |
109.00 |
1 |
insulin-like growth factor binding protein 2 |
| 12 |
Ovis aries |
106.00 |
1 |
insulin-like growth factor-binding protein-2 |
| 13 |
Equus caballus |
92.80 |
1 |
insulin-like growth factor binding protein-2 |
| 14 |
Monodelphis domestica |
76.60 |
1 |
PREDICTED: similar to Insulin-like growth factor-b |
| 15 |
Gallus gallus |
75.10 |
3 |
insulin-like growth factor binding protein 2 |
| 16 |
Coturnix coturnix |
60.50 |
1 |
AF260701_1 IGF binding protein 2 |
| 17 |
Xenopus tropicalis |
40.40 |
1 |
Unknown (protein for MGC:121849) |
Top-ranked sequences
| organism | matching |
|---|
| Mus musculus |
Query 151 LGGGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAKHLSLEEPKKLRPPPARTPCQQE 210
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 151 LGGGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAKHLSLEEPKKLRPPPARTPCQQE 210
|
| N/A |
Query 151 LGGGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAKHLSLEEPKKLRPPPARTPCQQE 210
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 151 LGGGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAKHLSLEEPKKLRPPPARTPCQQE 210
|
| Rattus norvegicus |
Query 153 GGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAKHLSLEEPKKLRPPPARTPCQQE 210
||||||||| ||||||||||||||||||#||||||||||||||||||||||||||||||
Sbjct 152 GGSSAGRKPPKSGMKELAVFREKVNEQH#RQMGKGAKHLSLEEPKKLRPPPARTPCQQE 209
|
| Homo sapiens |
Query 151 LGGGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAK-HLSLEEPKKLRPPPARTPCQQ 209
|||| ||||||||||||||||||||| |||#|||||| | || ||||||||||||||||||
Sbjct 173 LGGGGSAGRKPLKSGMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 232
Query 210 E 210
|
Query 210 E 210
|
| Pan troglodytes |
Query 151 LGGGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAK-HLSLEEPKKLRPPPARTPCQQ 209
|||| ||||||||||||||||||||| |||#|||||| | || ||||||||||||||||||
Sbjct 291 LGGGGSAGRKPLKSGMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 350
Query 210 E 210
|
Query 210 E 210
|
| synthetic construct |
Query 151 LGGGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAK-HLSLEEPKKLRPPPARTPCQQ 209
|||| ||||||||||||||||||||| |||#|||||| | || ||||||||||||||||||
Sbjct 173 LGGGGSAGRKPLKSGMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 232
Query 210 E 210
|
Query 210 E 210
|
| Macaca mulatta |
Query 151 LGGGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAK-HLSLEEPKKLRPPPARTPCQQ 209
|||| ||||||||||||||||||||| |||#|||||| | || ||||||||||||||||||
Sbjct 171 LGGGGSAGRKPLKSGMKELAVFREKVAEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 230
Query 210 E 210
|
Query 210 E 210
|
| Bubalus bubalis |
Query 151 LGGGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAK-HLSLEEPKKLRPPPARTPCQQ 209
+||| |||||||||||||||||||| |||#|||||| | || ||||||||||||||||||
Sbjct 36 MGGGGGAGRKPLKSGMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 95
Query 210 E 210
|
Query 210 E 210
|
| Bos taurus |
Query 151 LGGGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAK-HLSLEEPKKLRPPPARTPCQQ 209
+||| |||||||||||||||||||| |||#|||||| | || ||||||||||||||||||
Sbjct 162 MGGGGGAGRKPLKSGMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
Query 210 E 210
|
Query 210 E 210
|
| Canis familiaris |
Query 151 LGGGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAK-HLSLEEPKKLRPPPARTPCQQ 209
|||| |||||||||||||||||||| |||#|||||| | || |+||||||||||||||||
Sbjct 116 LGGGGGAGRKPLKSGMKELAVFREKVTEQH#RQMGKGGKHHLGLDEPKKLRPPPARTPCQQ 175
Query 210 E 210
|
Query 210 E 210
|
| Sus scrofa |
Query 151 LGGGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAK-HLSLEEPKKLRPPPARTPCQQ 209
||| |||||||||||||||||||| |||#|||||| | || ||||||||||||||||||
Sbjct 161 LGGTGGAGRKPLKSGMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 220
Query 210 E 210
|
Query 210 E 210
|
| Ovis aries |
Query 151 LGGGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAK-HLSLEEPKKLRPPPARTPCQQ 209
+||| ||||||| ||||||||||| |||#|||||| | || ||||||||||||||||||
Sbjct 162 MGGGGGAGRKPLKFRMKELAVFREKVTEQH#RQMGKGGKHHLGLEEPKKLRPPPARTPCQQ 221
Query 210 E 210
|
Query 210 E 210
|
| Equus caballus |
Query 158 GRKPLKSGMKELAVFREKVNEQH#RQMGKGAK--HLSLEEPKKLRPPPARTPCQQE 210
||||||||||||||+||||+ ||#||||+| | |+ |||||||||| ||||||||
Sbjct 1 GRKPLKSGMKELAVYREKVSGQH#RQMGRGGKHHHVVLEEPKKLRPPSARTPCQQE 55
|
| Monodelphis domestica |
Query 151 LGGGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAKHLSL-EEPKKLRPPPARTPCQQ 209
|||| ||| ||||||||| |||| ||#||+|| | + |+ ||||||| ||||||
Sbjct 167 LGGGV---RKPHKSGMKELAVIREKVIGQH#RQLGKVNMHHHIHEDTKKLRPPPTRTPCQQ 223
Query 210 E 210
|
Query 210 E 210
|
| Gallus gallus |
Query 151 LGGGSSAGRKPLKSGMKELAVFREKVNEQH#RQMGK-GAKHLSLEEPKKLRPPPARTPCQQ 209
| | || |||||+||||+|| ||||||| #||||| | | + |+ || | | ||||||
Sbjct 55 LSGASS--RKPLKTGMKEMAVMREKVNEQQ#RQMGKVGKAHHNHEDSKKSRMPTGRTPCQQ 112
Query 210 E 210
|
Query 210 E 210
|
| Coturnix coturnix |
Query 166 MKELAVFREKVNEQH#RQMGK-GAKHLSLEEPKKLRPPPARTPCQQE 210
|||+|| ||||||| #||||| | | + |+ || | | |||||||
Sbjct 1 MKEMAVMREKVNEQQ#RQMGKVGKAHHNHEDSKKSRMPTGRTPCQQE 46
|
| Xenopus tropicalis |
Query 154 GSSAGRKPLKSGMKELAVFREKVNEQH#RQMGKGAKHLSLEEPKKLRPPPARTPCQ 208
| +| ||| | |||+|| ||+ ||| #| +| |+ |+ |||+ ||
Sbjct 143 GEAAPRKPSKKEMKEIAVTRERANEQQ#R-----SKSNKSEDKKR----PARSLCQ 188
|
* References
[PubMed ID: 7529732] Schuller AG, Groffen C, van Neck JW, Zwarthoff EC, Drop SL, cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins. Mol Cell Endocrinol. 1994 Aug;104(1):57-66.
