XSB2169 : cortactin [Bos taurus]
[ CaMP Format ]
This entry is computationally expanded from SB0022
* Basic Information
| Organism | Bos taurus (cattle) |
| Protein Names | cortactin |
| Gene Names | CTTN; cortactin |
| Gene Locus | 29; chromosome 29 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_001068755 | NM_001075287 | 506939 | Q1RMR3_BOVIN | N/A | N/A | N/A | bta:506939 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 538 aa
Average Mass: 60.265 kDa
Monoisotopic Mass: 60.229 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| HS1_rep 1. | 83 | 119 | 68.2 | 3.1e-17 |
| HS1_rep 2. | 120 | 156 | 71.4 | 3.3e-18 |
| HS1_rep 3. | 157 | 193 | 70.8 | 4.9e-18 |
| HS1_rep 4. | 194 | 230 | 69.9 | 9.2e-18 |
| HS1_rep 5. | 231 | 267 | 65.7 | 1.8e-16 |
| HS1_rep 6. | 268 | 304 | 67.9 | 3.8e-17 |
| HS1_rep 7. | 305 | 341 | 29.4 | 1.4e-05 |
| --- cleavage 336 (inside HS1_rep 305..341) --- | ||||
| --- cleavage 346 --- | ||||
| --- cleavage 358 --- | ||||
| --- cleavage 351 --- | ||||
| ABM 1. | 413 | 469 | -9.8 | 7 |
| SH3_1 1. | 483 | 537 | 88.3 | 2.8e-23 |
3. Sequence Information
Fasta Sequence: XSB2169.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
4 [sites]
Cleavage sites (±10aa)
[Site 1] TVPVEAVNSK346-TSNIRANFEN
Lys346 
Thr
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Thr337 | Val338 | Pro339 | Val340 | Glu341 | Ala342 | Val343 | Asn344 | Ser345 | Lys346 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Thr347 | Ser348 | Asn349 | Ile350 | Arg351 | Ala352 | Asn353 | Phe354 | Glu355 | Asn356 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| MDKNASTFEDVAAVSSSYQKTVPVEAVNSKTSNIRANFENLAKEKEQEDRRKAEAERAQR |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Bos taurus | 117.00 | 2 | cortactin |
| 2 | Homo sapiens | 110.00 | 10 | cortactin isoform a |
| 3 | synthetic construct | 110.00 | 3 | cortactin |
| 4 | Macaca fascicularis | 110.00 | 2 | unnamed protein product |
| 5 | Macaca mulatta | 110.00 | 2 | PREDICTED: similar to cortactin isoform a |
| 6 | Pongo pygmaeus | 109.00 | 1 | hypothetical protein |
| 7 | Canis familiaris | 108.00 | 5 | PREDICTED: similar to cortactin isoform a isoform |
| 8 | Mus musculus | 105.00 | 5 | cortactin |
| 9 | Rattus norvegicus | 105.00 | 4 | cortactin isoform B |
| 10 | N/A | 105.00 | 2 | S |
| 11 | mice, BALB/c 3T3 cells, Peptide, 546 aa | 105.00 | 1 | cortactin, p80/p85 |
| 12 | Gallus gallus | 94.40 | 2 | cortactin |
| 13 | Xenopus laevis | 92.40 | 4 | cortactin |
| 14 | Tetraodon nigroviridis | 74.30 | 4 | unnamed protein product |
| 15 | Danio rerio | 72.80 | 5 | cortactin |
| 16 | Xenopus tropicalis | 61.60 | 1 | cortactin |
| 17 | Strongylocentrotus purpuratus | 54.30 | 1 | SRC8 protein |
| 18 | Aedes aegypti | 50.10 | 2 | cortactin |
| 19 | Pan troglodytes | 49.30 | 2 | PREDICTED: hypothetical protein isoform 1 |
| 20 | Drosophila melanogaster | 39.70 | 2 | Cortactin |
| 21 | Drosophila pseudoobscura | 38.50 | 1 | GA17577-PA |
| 22 | Monodelphis domestica | 35.80 | 1 | PREDICTED: similar to KIAA1561 protein |
| 23 | Anopheles gambiae str. PEST | 33.50 | 1 | ENSANGP00000029554 |
| 24 | Arabidopsis thaliana | 33.10 | 2 | unnamed protein product |
Top-ranked sequences
| organism | matching |
|---|---|
| Bos taurus | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 |
| Homo sapiens | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 ||||||||||| |||+|||||||||| ||#|||||||||||||||||||||||||||||| Sbjct 317 MDKNASTFEDVTQVSSAYQKTVPVEAVTSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 |
| synthetic construct | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 ||||||||||| |||+|||||||||| ||#|||||||||||||||||||||||||||||| Sbjct 280 MDKNASTFEDVTQVSSAYQKTVPVEAVTSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 339 |
| Macaca fascicularis | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 ||||||||||| |||+|||||||||| ||#|||||||||||||||||||||||||||||| Sbjct 1 MDKNASTFEDVTQVSSAYQKTVPVEAVTSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 60 |
| Macaca mulatta | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 ||||||||||| |||+|||||||||| ||#|||||||||||||||||||||||||||||| Sbjct 317 MDKNASTFEDVTQVSSAYQKTVPVEAVTSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 |
| Pongo pygmaeus | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 ||||||||||| |||+|||||||||| ||#|||||||||||||||||||||||||||||| Sbjct 280 MDKNASTFEDVTQVSSAYQKTVPVEAVASK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 339 |
| Canis familiaris | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 |||||||||||| |+ +||||||||||||+#||||||||||||||||||||||||||+||| Sbjct 317 MDKNASTFEDVAQVAPAYQKTVPVEAVNSR#TSNIRANFENLAKEKEQEDRRKAEAEKAQR 376 |
| Mus musculus | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 |||||||||+| | |+||||||+||| ||#||||||||||||||+||||||||||||||| Sbjct 317 MDKNASTFEEVVQVPSAYQKTVPIEAVTSK#TSNIRANFENLAKEREQEDRRKAEAERAQR 376 |
| Rattus norvegicus | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 |||||||||+| | |+||||||+||| ||#||||||||||||||+||||||||||||||| Sbjct 280 MDKNASTFEEVVQVPSAYQKTVPIEAVTSK#TSNIRANFENLAKEREQEDRRKAEAERAQR 339 |
| N/A | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 |||||||||+| | |+||||||+||| ||#||||||||||||||+||||||||||||||| Sbjct 317 MDKNASTFEEVVQVPSAYQKTVPIEAVTSK#TSNIRANFENLAKEREQEDRRKAEAERAQR 376 |
| mice, BALB/c 3T3 cells, Peptide, 546 aa | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 |||||||||+| | |+||||||+||| ||#||||||||||||||+||||||||||||||| Sbjct 317 MDKNASTFEEVVQVPSAYQKTVPIEAVTSK#TSNIRANFENLAKEREQEDRRKAEAERAQR 376 |
| Gallus gallus | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 |||||+||||+ +|+|||| ||| | +|#||+|||| |||||||||||||||||||||| Sbjct 326 MDKNAATFEDIEKPTSTYQKTKPVERVANK#TSSIRANLENLAKEKEQEDRRKAEAERAQR 385 |
| Xenopus laevis | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 ||| |++|||| |||||||| ||| ||# |+||||||||||+||||||+||||||||| Sbjct 315 MDKAAASFEDVEKVSSSYQKTRPVEVEGSK#ASSIRANFENLAKDKEQEDRKKAEAERAQR 374 |
| Tetraodon nigroviridis | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 ||| | |||+| + ||||| |||| | # +|+| |||+||+|| ||||+|| || +| Sbjct 325 MDKAAGTFEEVEKPTPSYQKTKPVEAAGSN#AGSIKARFENMAKQKEDEDRRRAEEERLRR 384 |
| Danio rerio | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 |||+| |||+| |++|||| |||| +| # |+|+| |||+||+||+|++++ | ||++| Sbjct 316 MDKSAGTFEEVQKPSAAYQKTRPVEAASSS#ASSIKARFENIAKQKEEEEQQRLEEERSRR 375 |
| Xenopus tropicalis | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 +|| || | ++ ||+|+|| |+||+ | # |+|+ |||+|+ |+|+++||| || +| Sbjct 278 VDKCASGFGEIETPSSAYEKTQPLEAMTSG#AHNLRSRFENMARTAEEENKQKAEEERVRR 337 |
| Strongylocentrotus purpuratus | Query 318 DKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 | | | |+ |||||+|| | | # |+| || +|+ |+| ||||| || +| Sbjct 281 DATAGGFGDMQGVSSSYKKTRPQPPAKSG#AGNMRNKFEQMAQAGEEESRRKAEEERGRR 339 |
| Aedes aegypti | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 |||+| |++ + ++| || | + ++|# ||||| ||| | |+| |+||| ++ | Sbjct 241 MDKSALGFQEQDKIGTNYTKTKP-DIGSAK#PSNIRARFENFAMAAEEETRKKAEEQKRLR 299 |
| Pan troglodytes | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 +||+| | ++ | +++|+|| |+|| +| # ++| ||++|+|| |++ | |+||+ Sbjct 246 VDKSAVGFNEMEAPTTAYKKTTPIEAASSG#ARGLKAKFESMAEEK----RKREEEEKAQQ 301 |
| Drosophila melanogaster | Query 345 SK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 +|# ||+|| |||||| |+| |++|| ++ | Sbjct 238 AK#PSNLRAKFENLAKNSEEESRKRAEEQKRLR 269 |
| Drosophila pseudoobscura | Query 345 SK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 +|# ||+|| |||||| |+| |+++| ++ | Sbjct 236 AK#PSNLRAKFENLAKNSEEESRKRSEEQKRLR 267 |
| Monodelphis domestica | Query 317 MDKNASTFEDVAAVSSSYQKTVPVEAVNSK#TSNIRANFENLAKEKEQEDRRKAEAERA 374 +++|| +| | + || ||+ | + # +++ + | | +| + + || ||+|| Sbjct 1146 LEENAKQNSEVLAAQALLQKHVPLGQVEAL#KNSLSSTIEALREELKDKQRRHEEAQRA 1203 |
| Anopheles gambiae str. PEST | Query 344 NSK#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 ++|# ||+|| ||| | |+| |++|+ ++ | Sbjct 237 SAK#PSNLRAKFENFAATAEEEARKRADEQKRLR 269 |
| Arabidopsis thaliana | Query 346 K#TSNIRANFENLAKEKEQEDRRKAEAERAQR 376 |# | +|+ + + ||||+|||++ || + +| Sbjct 740 K#LRNFKADLQKMKKEKEEEDRKRIEALKIER 770 |
[Site 2] VAAVSSSYQK336-TVPVEAVNSK
Lys336 Thr
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val327 | Ala328 | Ala329 | Val330 | Ser331 | Ser332 | Ser333 | Tyr334 | Gln335 | Lys336 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Thr337 | Val338 | Pro339 | Val340 | Glu341 | Ala342 | Val343 | Asn344 | Ser345 | Lys346 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| GGKYGVQKDRMDKNASTFEDVAAVSSSYQKTVPVEAVNSKTSNIRANFENLAKEKEQEDR |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Bos taurus | 120.00 | 2 | cortactin |
| 2 | Homo sapiens | 113.00 | 10 | SRC8_HUMAN Src substrate cortactin (Amplaxin) (Onc |
| 3 | synthetic construct | 113.00 | 3 | cortactin |
| 4 | Macaca mulatta | 113.00 | 2 | PREDICTED: similar to cortactin isoform a |
| 5 | Canis familiaris | 112.00 | 5 | PREDICTED: similar to cortactin isoform a isoform |
| 6 | Pongo pygmaeus | 112.00 | 1 | hypothetical protein |
| 7 | Mus musculus | 108.00 | 5 | cortactin |
| 8 | Rattus norvegicus | 108.00 | 4 | cortactin isoform B |
| 9 | N/A | 108.00 | 2 | S |
| 10 | mice, BALB/c 3T3 cells, Peptide, 546 aa | 108.00 | 1 | cortactin, p80/p85 |
| 11 | Gallus gallus | 97.40 | 2 | cortactin |
| 12 | Xenopus laevis | 96.70 | 3 | cortactin |
| 13 | Macaca fascicularis | 92.00 | 2 | unnamed protein product |
| 14 | Danio rerio | 85.10 | 4 | cortactin |
| 15 | Tetraodon nigroviridis | 82.40 | 3 | unnamed protein product |
| 16 | Aedes aegypti | 59.70 | 1 | cortactin |
| 17 | Strongylocentrotus purpuratus | 54.70 | 1 | SRC8 protein |
| 18 | Drosophila melanogaster | 49.70 | 2 | Cortactin CG3637-PA |
| 19 | Drosophila pseudoobscura | 49.70 | 1 | GA17577-PA |
| 20 | Pan troglodytes | 42.00 | 5 | PREDICTED: cortactin isoform 3 |
| 21 | Monodelphis domestica | 38.10 | 1 | PREDICTED: hypothetical protein |
| 22 | Anopheles gambiae str. PEST | 32.70 | 1 | ENSANGP00000029554 |
| 23 | Suberites domuncula | 32.70 | 1 | cortactin |
| 24 | Xenopus tropicalis | 32.30 | 1 | cortactin |
| 25 | Tribolium castaneum | 32.30 | 1 | PREDICTED: similar to Xaa-Pro dipeptidase (X-Pro d |
Top-ranked sequences
| organism | matching |
|---|---|
| Bos taurus | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 |
| Homo sapiens | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 ||||||||||||||||||||| |||+|||#||||||| |||||||||||||||||||||| Sbjct 307 GGKYGVQKDRMDKNASTFEDVTQVSSAYQK#TVPVEAVTSKTSNIRANFENLAKEKEQEDR 366 |
| synthetic construct | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 ||||||||||||||||||||| |||+|||#||||||| |||||||||||||||||||||| Sbjct 270 GGKYGVQKDRMDKNASTFEDVTQVSSAYQK#TVPVEAVTSKTSNIRANFENLAKEKEQEDR 329 |
| Macaca mulatta | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 ||||||||||||||||||||| |||+|||#||||||| |||||||||||||||||||||| Sbjct 307 GGKYGVQKDRMDKNASTFEDVTQVSSAYQK#TVPVEAVTSKTSNIRANFENLAKEKEQEDR 366 |
| Canis familiaris | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 |||||||||||||||||||||| |+ +|||#|||||||||+|||||||||||||||||||| Sbjct 307 GGKYGVQKDRMDKNASTFEDVAQVAPAYQK#TVPVEAVNSRTSNIRANFENLAKEKEQEDR 366 |
| Pongo pygmaeus | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 ||||||||||||||||||||| |||+|||#||||||| |||||||||||||||||||||| Sbjct 270 GGKYGVQKDRMDKNASTFEDVTQVSSAYQK#TVPVEAVASKTSNIRANFENLAKEKEQEDR 329 |
| Mus musculus | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 |||||||||||||||||||+| | |+|||#|||+||| ||||||||||||||||+||||| Sbjct 307 GGKYGVQKDRMDKNASTFEEVVQVPSAYQK#TVPIEAVTSKTSNIRANFENLAKEREQEDR 366 |
| Rattus norvegicus | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 |||||||||||||||||||+| | |+|||#|||+||| ||||||||||||||||+||||| Sbjct 270 GGKYGVQKDRMDKNASTFEEVVQVPSAYQK#TVPIEAVTSKTSNIRANFENLAKEREQEDR 329 |
| N/A | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 |||||||||||||||||||+| | |+|||#|||+||| ||||||||||||||||+||||| Sbjct 307 GGKYGVQKDRMDKNASTFEEVVQVPSAYQK#TVPIEAVTSKTSNIRANFENLAKEREQEDR 366 |
| mice, BALB/c 3T3 cells, Peptide, 546 aa | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 |||||||||||||||||||+| | |+|||#|||+||| ||||||||||||||||+||||| Sbjct 307 GGKYGVQKDRMDKNASTFEEVVQVPSAYQK#TVPIEAVTSKTSNIRANFENLAKEREQEDR 366 |
| Gallus gallus | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 |||||||||||||||+||||+ +|+|||#| ||| | +|||+|||| |||||||||||| Sbjct 316 GGKYGVQKDRMDKNAATFEDIEKPTSTYQK#TKPVERVANKTSSIRANLENLAKEKEQEDR 375 |
| Xenopus laevis | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 ||||||||||||| |++|||| |||||||#| ||| || |+||||||||||+|||||| Sbjct 305 GGKYGVQKDRMDKAAASFEDVEKVSSSYQK#TRPVEVEGSKASSIRANFENLAKDKEQEDR 364 |
| Macaca fascicularis | Query 317 MDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 ||||||||||| |||+|||#||||||| |||||||||||||||||||||| Sbjct 1 MDKNASTFEDVTQVSSAYQK#TVPVEAVTSKTSNIRANFENLAKEKEQEDR 50 |
| Danio rerio | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 |||||||||||||+| |||+| |++|||#| |||| +| |+|+| |||+||+||+|++ Sbjct 306 GGKYGVQKDRMDKSAGTFEEVQKPSAAYQK#TRPVEAASSSASSIKARFENIAKQKEEEEQ 365 |
| Tetraodon nigroviridis | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 |||+||||||||| | |||+| + ||||#| |||| | +|+| |||+||+|| ||| Sbjct 315 GGKFGVQKDRMDKAAGTFEEVEKPTPSYQK#TKPVEAAGSNAGSIKARFENMAKQKEDEDR 374 |
| Aedes aegypti | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 |||+||| |||||+| |++ + ++| |#| | + ++| ||||| ||| | |+| | Sbjct 231 GGKFGVQSDRMDKSALGFQEQDKIGTNYTK#TKP-DIGSAKPSNIRARFENFAMAAEEETR 289 |
| Strongylocentrotus purpuratus | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 |||+|| |+ | | | |+ |||||+|#| | | |+| || +|+ |+| | Sbjct 270 GGKFGVDKNAQDATAGGFGDMQGVSSSYKK#TRPQPPAKSGAGNMRNKFEQMAQAGEEESR 329 |
| Drosophila melanogaster | Query 307 GGKYGVQKDRMDKNASTFEDVAA----VSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKE 362 |||+|||+|| ||+| ++ | | |# || +| ||+|| |||||| | Sbjct 197 GGKFGVQEDRKDKSAVGWDHKEAPQKHASQVDHK#VKPV-IEGAKPSNLRAKFENLAKNSE 255 Query 363 QEDR 366 +| | Sbjct 256 EESR 259 |
| Drosophila pseudoobscura | Query 307 GGKYGVQKDRMDKNASTFEDVAA----VSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKE 362 |||+|||+|| ||+| ++ | | |# || +| ||+|| |||||| | Sbjct 195 GGKFGVQEDRKDKSAVGWDHKEAPQKHASQVDHK#VKPV-IEGAKPSNLRAKFENLAKNSE 253 Query 363 QEDR 366 +| | Sbjct 254 EESR 257 |
| Pan troglodytes | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKT 347 |||||||||||||++ + | + ||# || |+ + | Sbjct 307 GGKYGVQKDRMDKSSPSLGQTIVESPAMQK#GFPVAAIVTTT 347 |
| Monodelphis domestica | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#T---VPVEAVNSKTSNIRANFENLAKEKEQ 363 ||||||||||||| | | | |#+ | | |++ | | + | Sbjct 270 GGKYGVQKDRMDKRGGTAEPQAQSGRPQTK#SSLLTLATGVPCSISGIKSAFSNHQTPQAQ 329 Query 364 ED 365 | Sbjct 330 SD 331 |
| Anopheles gambiae str. PEST | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSS-----SYQK#TVPVEAVNSKTSNIRANFENLAKEK 361 |||+||| || ||+| ++ | ++ # + + ++| ||+|| ||| | Sbjct 195 GGKFGVQTDRKDKSAFGWDHVEKPQMHESQLDHKI#VIKPDIGSAKPSNLRAKFENFAATA 254 Query 362 EQEDR 366 |+| | Sbjct 255 EEEAR 259 Query 307 GGKYGVQKDRMDKNASTFEDVAAV 330 |||+||+||||||+| | + | Sbjct 84 GGKFGVEKDRMDKSAVGHEHIEKV 107 Query 307 GGKYGVQKDRMDKNASTFEDVAAV 330 |||+||||||+||+| ++ | | Sbjct 121 GGKFGVQKDRVDKSAHGWDHVEKV 144 |
| Suberites domuncula | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLA 358 ||||||++ | +| ++|+ || | ++ # | +| +||+ |||+| Sbjct 271 GGKYGVEEGNQDSSAGGYDDMQAVKSDHRT#ERGVS--KGQTGSIRSKFENMA 320 Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFE----------N 356 ||||||||+| ||+| ++ | ++ +#| + | || + | Sbjct 87 GGKYGVQKERQDKSAVGWDYQANLAKHGSQ#TDAAKGFGGKYGVQDANKDKSAVGWDYQAN 146 Query 357 LAKEKEQED 365 ||| | | Sbjct 147 LAKHGSQTD 155 |
| Xenopus tropicalis | Query 307 GGKYGVQKDRMDKNASTFEDVAAVSSSYQK#TVPVEAVNSKTSNIRANFENLAKEKEQEDR 366 ||++||| ||+|| || | ++ ||+|+|#| |+||+ | |+|+ |||+|+ |+|++ Sbjct 268 GGRFGVQTDRVDKCASGFGEIETPSSAYEK#TQPLEAMTSGAHNLRSRFENMARTAEEENK 327 Query 307 GGKYGVQKDRMDKNASTFEDVAAV 330 |||||||||| ||+| |+ | | Sbjct 120 GGKYGVQKDRTDKSAVGFDYKAKV 143 Query 307 GGKYGVQKDRMDKNASTF 324 |||||||||| ||+| ++ Sbjct 194 GGKYGVQKDRQDKSAHSW 211 |
| Tribolium castaneum | Query 307 GGKYGVQKDRMDKNASTFED-VAAVSSSYQK#TVPVEAVNSKTSNIRANFENL 357 |||+|+| ||+||+|+ | | | | ++| |# | + ++| ++|| |||+ Sbjct 736 GGKFGLQTDRVDKSAANFNDEPAKVGTNYTK#VKP-DIGDAKPKDLRAKFENM 786 Query 307 GGKYGVQKDRMDKNASTFEDVAAV 330 |||+|++|||||++| | || | Sbjct 87 GGKFGIEKDRMDQSAVGHEYVAKV 110 |
[Site 3] NIRANFENLA358-KEKEQEDRRK
Ala358 Lys
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Asn349 | Ile350 | Arg351 | Ala352 | Asn353 | Phe354 | Glu355 | Asn356 | Leu357 | Ala358 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Lys359 | Glu360 | Lys361 | Glu362 | Gln363 | Glu364 | Asp365 | Arg366 | Arg367 | Lys368 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| AVSSSYQKTVPVEAVNSKTSNIRANFENLAKEKEQEDRRKAEAERAQRMAQERQEQEAAR |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Bos taurus | 58.50 | 1 | cortactin |
| 2 | Homo sapiens | 53.50 | 6 | SRC8_HUMAN Src substrate cortactin (Amplaxin) (Onc |
| 3 | Macaca fascicularis | 53.50 | 1 | unnamed protein product |
| 4 | Macaca mulatta | 53.50 | 1 | PREDICTED: similar to cortactin isoform a |
| 5 | synthetic construct | 53.50 | 1 | cortactin |
| 6 | Pongo pygmaeus | 52.80 | 1 | hypothetical protein |
| 7 | Canis familiaris | 51.60 | 5 | PREDICTED: similar to cortactin isoform a isoform |
| 8 | Mus musculus | 51.20 | 3 | cortactin |
| 9 | Rattus norvegicus | 51.20 | 3 | cortactin isoform B |
| 10 | N/A | 51.20 | 1 | S |
| 11 | mice, BALB/c 3T3 cells, Peptide, 546 aa | 51.20 | 1 | cortactin, p80/p85 |
| 12 | Xenopus laevis | 44.30 | 3 | cortactin |
| 13 | Gallus gallus | 40.40 | 1 | cortactin |
| 14 | Danio rerio | 37.00 | 1 | cortactin |
| 15 | Tetraodon nigroviridis | 34.70 | 2 | unnamed protein product |
| 16 | Xenopus tropicalis | 34.70 | 1 | cortactin |
Top-ranked sequences
| organism | matching |
|---|---|
| Bos taurus | Query 329 AVSSSYQKTVPVEAVNSKTSNIRANFENL 357 ||||||||||||||||||||||||||||| Query 329 AVSSSYQKTVPVEAVNSKTSNIRANFENL 357 |
| Homo sapiens | Query 330 VSSSYQKTVPVEAVNSKTSNIRANFENL 357 |||+|||||||||| ||||||||||||| Sbjct 330 VSSAYQKTVPVEAVTSKTSNIRANFENL 357 |
| Macaca fascicularis | Query 330 VSSSYQKTVPVEAVNSKTSNIRANFENL 357 |||+|||||||||| ||||||||||||| Sbjct 14 VSSAYQKTVPVEAVTSKTSNIRANFENL 41 |
| Macaca mulatta | Query 330 VSSSYQKTVPVEAVNSKTSNIRANFENL 357 |||+|||||||||| ||||||||||||| Sbjct 330 VSSAYQKTVPVEAVTSKTSNIRANFENL 357 |
| synthetic construct | Query 330 VSSSYQKTVPVEAVNSKTSNIRANFENL 357 |||+|||||||||| ||||||||||||| Sbjct 293 VSSAYQKTVPVEAVTSKTSNIRANFENL 320 |
| Pongo pygmaeus | Query 330 VSSSYQKTVPVEAVNSKTSNIRANFENL 357 |||+|||||||||| ||||||||||||| Sbjct 293 VSSAYQKTVPVEAVASKTSNIRANFENL 320 |
| Canis familiaris | Query 330 VSSSYQKTVPVEAVNSKTSNIRANFENL 357 |+ +||||||||||||+||||||||||| Sbjct 330 VAPAYQKTVPVEAVNSRTSNIRANFENL 357 |
| Mus musculus | Query 330 VSSSYQKTVPVEAVNSKTSNIRANFENL 357 | |+||||||+||| ||||||||||||| Sbjct 330 VPSAYQKTVPIEAVTSKTSNIRANFENL 357 |
| Rattus norvegicus | Query 330 VSSSYQKTVPVEAVNSKTSNIRANFENL 357 | |+||||||+||| ||||||||||||| Sbjct 293 VPSAYQKTVPIEAVTSKTSNIRANFENL 320 |
| N/A | Query 330 VSSSYQKTVPVEAVNSKTSNIRANFENL 357 | |+||||||+||| ||||||||||||| Sbjct 330 VPSAYQKTVPIEAVTSKTSNIRANFENL 357 |
| mice, BALB/c 3T3 cells, Peptide, 546 aa | Query 330 VSSSYQKTVPVEAVNSKTSNIRANFENL 357 | |+||||||+||| ||||||||||||| Sbjct 330 VPSAYQKTVPIEAVTSKTSNIRANFENL 357 |
| Xenopus laevis | Query 330 VSSSYQKTVPVEAVNSKTSNIRANFENL 357 |||||||| ||| || |+|||||||| Sbjct 328 VSSSYQKTRPVEVEGSKASSIRANFENL 355 |
| Gallus gallus | Query 331 SSSYQKTVPVEAVNSKTSNIRANFENL 357 +|+|||| ||| | +|||+|||| ||| Sbjct 340 TSTYQKTKPVERVANKTSSIRANLENL 366 |
| Danio rerio | Query 331 SSSYQKTVPVEAVNSKTSNIRANFENL 357 |++|||| |||| +| |+|+| |||+ Sbjct 330 SAAYQKTRPVEAASSSASSIKARFENI 356 |
| Tetraodon nigroviridis | Query 333 SYQKTVPVEAVNSKTSNIRANFENL 357 ||||| |||| | +|+| |||+ Sbjct 341 SYQKTKPVEAAGSNAGSIKARFENM 365 |
| Xenopus tropicalis | Query 331 SSSYQKTVPVEAVNSKTSNIRANFENL 357 ||+|+|| |+||+ | |+|+ |||+ Sbjct 292 SSAYEKTQPLEAMTSGAHNLRSRFENM 318 |
[Site 4] AVNSKTSNIR351-ANFENLAKEK
Arg351 Ala
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ala342 | Val343 | Asn344 | Ser345 | Lys346 | Thr347 | Ser348 | Asn349 | Ile350 | Arg351 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala352 | Asn353 | Phe354 | Glu355 | Asn356 | Leu357 | Ala358 | Lys359 | Glu360 | Lys361 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| STFEDVAAVSSSYQKTVPVEAVNSKTSNIRANFENLAKEKEQEDRRKAEAERAQRMAQER |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Bos taurus | 71.60 | 2 | cortactin |
| 2 | Homo sapiens | 64.70 | 10 | cortactin isoform a |
| 3 | synthetic construct | 64.70 | 3 | cortactin |
| 4 | Macaca mulatta | 64.70 | 2 | PREDICTED: similar to cortactin isoform a |
| 5 | Macaca fascicularis | 64.70 | 2 | unnamed protein product |
| 6 | Canis familiaris | 64.30 | 5 | PREDICTED: similar to cortactin isoform a isoform |
| 7 | Pongo pygmaeus | 63.90 | 1 | hypothetical protein |
| 8 | Mus musculus | 60.80 | 5 | cortactin |
| 9 | Rattus norvegicus | 60.80 | 4 | cortactin isoform B |
| 10 | mice, BALB/c 3T3 cells, Peptide, 546 aa | 60.80 | 1 | cortactin, p80/p85 |
| 11 | N/A | 60.80 | 1 | S |
| 12 | Xenopus laevis | 52.40 | 3 | cortactin |
| 13 | Gallus gallus | 48.90 | 2 | cortactin |
| 14 | Danio rerio | 43.90 | 1 | cortactin |
| 15 | Tetraodon nigroviridis | 41.60 | 3 | unnamed protein product |
| 16 | Xenopus tropicalis | 37.70 | 1 | cortactin |
| 17 | Pan troglodytes | 33.10 | 2 | PREDICTED: hypothetical protein isoform 1 |
Top-ranked sequences
| organism | matching |
|---|---|
| Bos taurus | Query 322 STFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 ||||||||||||||||||||||||||||||#|||||| Query 322 STFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 |
| Homo sapiens | Query 322 STFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 |||||| |||+|||||||||| |||||||#|||||| Sbjct 322 STFEDVTQVSSAYQKTVPVEAVTSKTSNIR#ANFENL 357 |
| synthetic construct | Query 322 STFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 |||||| |||+|||||||||| |||||||#|||||| Sbjct 285 STFEDVTQVSSAYQKTVPVEAVTSKTSNIR#ANFENL 320 |
| Macaca mulatta | Query 322 STFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 |||||| |||+|||||||||| |||||||#|||||| Sbjct 322 STFEDVTQVSSAYQKTVPVEAVTSKTSNIR#ANFENL 357 |
| Macaca fascicularis | Query 322 STFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 |||||| |||+|||||||||| |||||||#|||||| Sbjct 6 STFEDVTQVSSAYQKTVPVEAVTSKTSNIR#ANFENL 41 |
| Canis familiaris | Query 322 STFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 ||||||| |+ +||||||||||||+|||||#|||||| Sbjct 322 STFEDVAQVAPAYQKTVPVEAVNSRTSNIR#ANFENL 357 |
| Pongo pygmaeus | Query 322 STFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 |||||| |||+|||||||||| |||||||#|||||| Sbjct 285 STFEDVTQVSSAYQKTVPVEAVASKTSNIR#ANFENL 320 |
| Mus musculus | Query 322 STFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 ||||+| | |+||||||+||| |||||||#|||||| Sbjct 322 STFEEVVQVPSAYQKTVPIEAVTSKTSNIR#ANFENL 357 |
| Rattus norvegicus | Query 322 STFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 ||||+| | |+||||||+||| |||||||#|||||| Sbjct 285 STFEEVVQVPSAYQKTVPIEAVTSKTSNIR#ANFENL 320 |
| mice, BALB/c 3T3 cells, Peptide, 546 aa | Query 322 STFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 ||||+| | |+||||||+||| |||||||#|||||| Sbjct 322 STFEEVVQVPSAYQKTVPIEAVTSKTSNIR#ANFENL 357 |
| N/A | Query 322 STFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 ||||+| | |+||||||+||| |||||||#|||||| Sbjct 322 STFEEVVQVPSAYQKTVPIEAVTSKTSNIR#ANFENL 357 |
| Xenopus laevis | Query 322 STFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 ++|||| |||||||| ||| || |+||#|||||| Sbjct 320 ASFEDVEKVSSSYQKTRPVEVEGSKASSIR#ANFENL 355 |
| Gallus gallus | Query 322 STFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 +||||+ +|+|||| ||| | +|||+||#|| ||| Sbjct 331 ATFEDIEKPTSTYQKTKPVERVANKTSSIR#ANLENL 366 |
| Danio rerio | Query 323 TFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 |||+| |++|||| |||| +| |+|+#| |||+ Sbjct 322 TFEEVQKPSAAYQKTRPVEAASSSASSIK#ARFENI 356 |
| Tetraodon nigroviridis | Query 323 TFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 |||+| + ||||| |||| | +|+#| |||+ Sbjct 331 TFEEVEKPTPSYQKTKPVEAAGSNAGSIK#ARFENM 365 |
| Xenopus tropicalis | Query 322 STFEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 | | ++ ||+|+|| |+||+ | |+|#+ |||+ Sbjct 283 SGFGEIETPSSAYEKTQPLEAMTSGAHNLR#SRFENM 318 |
| Pan troglodytes | Query 324 FEDVAAVSSSYQKTVPVEAVNSKTSNIR#ANFENL 357 | ++ | +++|+|| |+|| +| ++#| ||++ Sbjct 253 FNEMEAPTTAYKKTTPIEAASSGARGLK#AKFESM 286 |
* References
None.