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XSB2173 : protein kinase C, alpha [Rattus norvegicus]

[ CaMP Format ]

This entry is computationally expanded from SB0055

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namesprotein kinase C; alpha
Gene NamesPrkca; protein kinase C, alpha
Gene Locus10q32.1; chromosome 10
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001099183 NM_001105713 24680 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 636 aa

Average Mass: 72.783 kDa

Monoisotopic Mass: 72.735 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
C1_1 1. 378983.29.4e-22
C1_1 2. 10215492.51.5e-24
C2 1. 173260137.93.3e-38
--- cleavage 309 ---
--- cleavage 324 ---
--- cleavage 316 ---
Pkinase 1. 339572214.33.2e-61
Pkinase_C 1. 58162655.81.6e-13

3. Sequence Information

Fasta Sequence: XSB2173.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

3 [sites]

Cleavage sites (±10aa)

[Site 1] ELRQKFEKAK309-LGPAGNKVIS

Lys309 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu300Leu301Arg302Gln303Lys304Phe305Glu306Lys307Ala308Lys309
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu310Gly311Pro312Ala313Gly314Asn315Lys316Val317Ile318Ser319

Sequence conservation (by blast)

[Site 2] NKVISPSEDR324-KQPSNNLDRV

Arg324 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asn315Lys316Val317Ile318Ser319Pro320Ser321Glu322Asp323Arg324
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys325Gln326Pro327Ser328Asn329Asn330Leu331Asp332Arg333Val334

Sequence conservation (by blast)

[Site 3] KAKLGPAGNK316-VISPSEDRKQ

Lys316 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys307Ala308Lys309Leu310Gly311Pro312Ala313Gly314Asn315Lys316
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val317Ile318Ser319Pro320Ser321Glu322Asp323Arg324Lys325Gln326

Sequence conservation (by blast)

* References

[PubMed ID: 19057126] Kashihara T, Nakayama K, Ishikawa T, Distinct roles of protein kinase C isoforms in myogenic constriction of rat posterior cerebral arteries. J Pharmacol Sci. 2008 Dec;108(4):446-54. Epub 2008 Dec 5.

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