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XSB2174 : Protein kinase C alpha type

[ CaMP Format ]

This entry is computationally expanded from SB0055

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein NamesPKC-alpha; PKC-A; 2.7.11.13
Gene NamesPkca
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
P05696 N/A N/A KPCA_RAT N/A N/A N/A rno:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 672 aa

Average Mass: 76.792 kDa

Monoisotopic Mass: 76.742 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
C1_1 1. 378983.29.4e-22
C1_1 2. 10215492.51.5e-24
C2 1. 173260137.93.3e-38
--- cleavage 309 ---
--- cleavage 324 ---
--- cleavage 316 ---
Pkinase 1. 339597291.22.2e-84
Pkinase_C 1. 61766255.81.6e-13

3. Sequence Information

Fasta Sequence: XSB2174.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1DSY (X-ray; 260 A; A=155-293), 3GPE (X-ray; 200 A; A=156-292)

* Cleavage Information

3 [sites]

Cleavage sites (±10aa)

[Site 1] ELRQKFEKAK309-LGPAGNKVIS

Lys309 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu300Leu301Arg302Gln303Lys304Phe305Glu306Lys307Ala308Lys309
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu310Gly311Pro312Ala313Gly314Asn315Lys316Val317Ile318Ser319

Sequence conservation (by blast)

[Site 2] NKVISPSEDR324-KQPSNNLDRV

Arg324 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asn315Lys316Val317Ile318Ser319Pro320Ser321Glu322Asp323Arg324
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys325Gln326Pro327Ser328Asn329Asn330Leu331Asp332Arg333Val334

Sequence conservation (by blast)

[Site 3] KAKLGPAGNK316-VISPSEDRKQ

Lys316 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys307Ala308Lys309Leu310Gly311Pro312Ala313Gly314Asn315Lys316
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val317Ile318Ser319Pro320Ser321Glu322Asp323Arg324Lys325Gln326

Sequence conservation (by blast)

* References

[PubMed ID: 3387228] Ono Y, Fujii T, Igarashi K, Kikkawa U, Ogita K, Nishizuka Y, Nucleotide sequences of cDNAs for alpha and gamma subspecies of rat brain protein kinase C. Nucleic Acids Res. 1988 Jun 10;16(11):5199-200.

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