logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2183 : elastic titin [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0101

* Basic Information

OrganismHomo sapiens (human)
Protein NamesTitin; 2.7.11.1; Connectin; Rhabdomyosarcoma antigen MU-RMS-40.14; elastic titin
Gene Namestitin; TTN
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
CAA62189 N/A N/A TITIN_HUMAN N/A 12403 N/A hsa:7273

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 7962 aa

Average Mass: 883.025 kDa

Monoisotopic Mass: 882.471 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
I-set 1. 1098121.13.6e-33
I-set 2. 12121097.45e-26
I-set 3. 21630585.51.8e-22
I-set 4. 309398106.87.6e-29
I-set 5. 40249284.92.8e-22
I-set 6. 49658569.41.3e-17
I-set 7. 58967895.81.5e-25
I-set 8. 68277183.38.6e-22
I-set 9. 77886798.72.1e-26
I-set 10. 87196079.71e-20
I-set 11. 964105497.15.9e-26
I-set 12. 1058114775.02.8e-19
I-set 13. 1151124059.41.4e-14
I-set 14. 1244133362.21.9e-15
I-set 15. 13401429101.43e-27
I-set 16. 1433152274.15.1e-19
I-set 17. 1526161699.71e-26
I-set 18. 16201709103.19.2e-28
I-set 19. 1713180276.21.2e-19
I-set 20. 1806189599.01.6e-26
I-set 21. 1902199177.54.7e-20
I-set 22. 1995208468.23.1e-17
I-set 23. 2088217889.71e-23
I-set 24. 21822271103.38.4e-28
I-set 25. 2275236576.87.8e-20
I-set 26. 23692458111.52.7e-30
I-set 27. 2465255495.12.5e-25
I-set 28. 2558264791.52.9e-24
I-set 29. 2651274054.34.7e-13
I-set 30. 27442833119.61e-32
I-set 31. 2840292969.41.3e-17
I-set 32. 29363025129.89e-36
I-set 33. 30293119111.52.8e-30
I-set 34. 31233212128.81.8e-35
I-set 35. 3216330680.85.1e-21
I-set 36. 3310339995.91.4e-25
I-set 37. 34063495102.12e-27
I-set 38. 3499358884.73.2e-22
I-set 39. 3592368173.95.8e-19
I-set 40. 36853774103.19.6e-28
I-set 41. 3781387078.81.9e-20
I-set 42. 38773966115.91.3e-31
I-set 43. 3970406092.21.8e-24
I-set 44. 4064415389.31.4e-23
I-set 45. 4157424791.13.8e-24
I-set 46. 42514340110.17.5e-30
I-set 47. 43474436108.22.7e-29
I-set 48. 44404529101.23.6e-27
I-set 49. 4533462276.68.8e-20
I-set 50. 46264715126.77.3e-35
I-set 51. 47224811102.71.3e-27
I-set 52. 48184907128.71.9e-35
I-set 53. 4914500474.34.6e-19
I-set 54. 50115100115.22.1e-31
I-set 55. 5119520979.71e-20
--- cleavage 5171 (inside I-set 5119..5209) ---
Nuc_rec_co-act 1. 52365282-0.25
I-set 56. 5321540732.81.3e-06
I-set 57. 5410549448.72.3e-11
I-set 58. 5499558868.23e-17
Extensin_1 1. 584458531.11.2e
PPAK 1. 586958946.14.6
PPAK 2. 589559223.315
PPAK 3. 5923594924.30.00049
PPAK 4. 5950597618.80.02
PPAK 5. 5977600430.47.2e-06
PPAK 6. 6005603233.49.3e-07
PPAK 7. 6033605934.05.8e-07
PPAK 8. 6060608519.80.011
PPAK 9. 6088611523.80.00071
PPAK 10. 611661497.32.7
PPAK 11. 6188621415.10.094
PPAK 12. 6241626834.54.3e-07
PPAK 13. 6269629627.65e-05
PPAK 14. 6298632426.79.3e-05
PPAK 15. 6325635228.82.1e-05
PPAK 16. 6353638031.33.8e-06
PPAK 17. 6475649917.00.043
PPAK 18. 6500652631.92.6e-06
PPAK 19. 6531655625.10.00028
PPAK 20. 655765854.78.1
PPAK 21. 6612663827.84.5e-05
PPAK 22. 6639666428.23.4e-05
PPAK 23. 6665669238.42.8e-08
PPAK 24. 6693672034.83.4e-07
PPAK 25. 6721674835.91.6e-07
PPAK 26. 6849687211.00.55
PPAK 27. 6873689720.20.0086
PPAK 28. 6930695513.30.21
PPAK 29. 6956697910.30.75
PPAK 30. 6980700320.00.01
PPAK 31. 700470263.514
PPAK 32. 710371306.24.3
PPAK 33. 7131715523.10.0011
PPAK 34. 7156718520.90.0054
PPAK 35. 7186721328.82.3e-05
PPAK 36. 7214724130.76.1e-06
PPAK 37. 7264729126.98e-05
PPAK 38. 7292731924.20.00054
PPAK 39. 7320734728.43e-05
PPAK 40. 7376740315.70.073
PPAK 41. 7404743132.22.1e-06
PPAK 42. 7432745728.13.5e-05
PPAK 43. 7458748534.54.3e-07
PPAK 44. 748675102.620
PPAK 45. 7522754727.17.1e-05
I-set 59. 7802789444.44.5e-10
Big_4 1. 79047949-12.56.8

3. Sequence Information

Fasta Sequence: XSB2183.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1BPV (NMR; -; A=22283-22385), 1G1C (X-ray; 210 A; A/B=2073-2171), 1NCT (NMR; -; A=33483-33579), 1NCU (NMR; -; A=33483-33579), 1TIT (NMR; -; A=12677-12765), 1TIU (NMR; -; A=12677-12765), 1TKI (X-ray; 200 A; A/B=32172-32492), 1TNM (NMR; -; A=33489-33579), 1TNN (NMR; -; A=33489-33579), 1WAA (X-ray; 180 A; A/B/C/D=12677-12765, E=12677-12765, F=12677-12765), 1YA5 (X-ray; 244 A; A/B=1-196), 2A38 (X-ray; 200 A; A/B/C=1-194), 2BK8 (X-ray; 169 A; A=32497-32590), 2F8V (X-ray; 275 A; A/B/C/D=1-196), 2ILL (X-ray; 220 A; A=31854-32047), 2J8H (X-ray; 199 A; A=31854-32047), 2J8O (X-ray; 249 A; A/B=31854-32047), 2NZI (X-ray; 290 A; A/B=31854-32155), 3B43 (X-ray; 330 A; A=7945-8511)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] QGGRVFIHQK5171-GDEAKLEIRD

Lys5171 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gln5162Gly5163Gly5164Arg5165Val5166Phe5167Ile5168His5169Gln5170Lys5171
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gly5172Asp5173Glu5174Ala5175Lys5176Leu5177Glu5178Ile5179Arg5180Asp5181

Sequence conservation (by blast)

* References

[PubMed ID: 7569978] Labeit S, Kolmerer B, Titins: giant proteins in charge of muscle ultrastructure and elasticity. Science. 1995 Oct 13;270(5234):293-6.