logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2194 : cardiac titin N2BA isoform [Rattus norvegicus]

[ CaMP Format ]

This entry is computationally expanded from SB0101

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namescardiac titin N2BA isoform
Gene NamesTtn
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAP80789 N/A N/A Q7TN00_RAT N/A N/A N/A rno:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 3410 aa

Average Mass: 375.761 kDa

Monoisotopic Mass: 375.525 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
I-set 1. 17155.91.6e-13
I-set 2. 7816777.64.4e-20
I-set 3. 174263130.17.3e-36
I-set 4. 267357108.03.1e-29
I-set 5. 361450119.69.9e-33
I-set 6. 45454483.95.5e-22
I-set 7. 548637102.11.9e-27
I-set 8. 644733104.24.5e-28
I-set 9. 73782683.01.1e-21
I-set 10. 83091963.57.7e-16
I-set 11. 9231012106.31e-28
I-set 12. 1019110888.62.1e-23
I-set 13. 11151204112.02e-30
I-set 14. 1208129894.05.3e-25
I-set 15. 1302139198.72.1e-26
I-set 16. 1395148593.38.2e-25
I-set 17. 1489157893.95.4e-25
I-set 18. 1585167495.32.1e-25
I-set 19. 16781767102.51.4e-27
I-set 20. 1771186074.15e-19
I-set 21. 18641953123.66.6e-34
I-set 22. 19602049102.02.1e-27
I-set 23. 20562145127.83.6e-35
I-set 24. 2152224276.01.4e-19
I-set 25. 22492338101.82.4e-27
I-set 26. 2357244782.71.3e-21
--- cleavage 2409 (inside I-set 2357..2447) ---
Nuc_rec_co-act 1. 24742520-1.27.2
I-set 27. 2559264531.53.4e-06
I-set 28. 2648273253.11.1e-12
I-set 29. 2737282668.23e-17
PPAK 1. 288029072.422
PPAK 2. 3081310830.75.9e-06
PPAK 3. 3109313632.51.7e-06
PPAK 4. 3137316434.25.2e-07
PPAK 5. 3165319317.50.034
Drf_FH1 1. 32513388-25.20.54

3. Sequence Information

Fasta Sequence: XSB2194.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] QGGRILIHQK2409-GDESKLEIRD

Lys2409 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gln2400Gly2401Gly2402Arg2403Ile2404Leu2405Ile2406His2407Gln2408Lys2409
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gly2410Asp2411Glu2412Ser2413Lys2414Leu2415Glu2416Ile2417Arg2418Asp2419

Sequence conservation (by blast)

* References

[PubMed ID: 12785098] Greaser ML, Berri M, Warren CM, Mozdziak PE, Species variations in cDNA sequence and exon splicing patterns in the extensible I-band region of cardiac titin: relation to passive tension. J Muscle Res Cell Motil. 2002;23(5-6):473-82.