logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2206 : Integrin beta-1

[ CaMP Format ]

This entry is computationally expanded from SB0063

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein NamesFibronectin receptor subunit beta; Integrin VLA-4 subunit beta; Beta oligodendroglia; Beta OL
Gene NamesItgb1
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
P49134 N/A N/A ITB1_RAT N/A N/A N/A rno:24511

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 799 aa

Average Mass: 88.495 kDa

Monoisotopic Mass: 88.436 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 344651123.80
EGF_2 1. 46750111.00.16
EGF_2 2. 51755420.90.0053
EGF_2 3. 56159123.80.0007
EGF_2 4. 60063135.12.8e-07
Integrin_B_tail 1. 641729153.75.5e-43
Integrin_b_cyt 1. 753798112.31.6e-30
--- cleavage 792 (inside Integrin_b_cyt 753..798) ---
--- cleavage 778 (inside Integrin_b_cyt 753..798) ---
--- cleavage 790 (inside Integrin_b_cyt 753..798) ---
--- cleavage 779 (inside Integrin_b_cyt 753..798) ---

3. Sequence Information

Fasta Sequence: XSB2206.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites]

Cleavage sites (±10aa)

[Site 1] IYKSAVTTVV792-NPKYEGK

Val792 Asn

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ile783Tyr784Lys785Ser786Ala787Val788Thr789Thr790Val791Val792
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asn793Pro794Lys795Tyr796Glu797Gly798Lys799---

Sequence conservation (by blast)

[Site 2] KEKMNAKWDT778-GENPIYKSAV

Thr778 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys769Glu770Lys771Met772Asn773Ala774Lys775Trp776Asp777Thr778
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gly779Glu780Asn781Pro782Ile783Tyr784Lys785Ser786Ala787Val788

Sequence conservation (by blast)

[Site 3] NPIYKSAVTT790-VVNPKYEGK

Thr790 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asn781Pro782Ile783Tyr784Lys785Ser786Ala787Val788Thr789Thr790
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val791Val792Asn793Pro794Lys795Tyr796Glu797Gly798Lys799-

Sequence conservation (by blast)

[Site 4] EKMNAKWDTG779-ENPIYKSAVT

Gly779 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu770Lys771Met772Asn773Ala774Lys775Trp776Asp777Thr778Gly779
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu780Asn781Pro782Ile783Tyr784Lys785Ser786Ala787Val788Thr789

Sequence conservation (by blast)

* References

[PubMed ID: 7541764] Malek-Hedayat S, Rome LH, Cloning and sequence of the cDNA encoding the rat oligodendrocyte integrin beta 1 subunit. Gene. 1995 Jun 9;158(2):287-90.

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