logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2208 : unnamed protein product [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0063

* Basic Information

OrganismHomo sapiens (human)
Protein NamesIntegrin beta-1; Fibronectin receptor subunit beta; Integrin VLA-4 subunit beta
Gene NamesFNRB, MDF2, MSK12; FNRB; MDF2; MSK12
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
CAA30790 N/A N/A ITB1_HUMAN N/A 6153 N/A hsa:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 798 aa

Average Mass: 88.465 kDa

Monoisotopic Mass: 88.407 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 344641124.20
EGF_2 1. 46650011.80.13
EGF_2 2. 51655321.30.0041
EGF_2 3. 56059021.90.0027
EGF_2 4. 59963033.77.6e-07
Integrin_B_tail 1. 640728159.01.4e-44
Integrin_b_cyt 1. 752797112.31.6e-30
--- cleavage 791 (inside Integrin_b_cyt 752..797) ---
--- cleavage 777 (inside Integrin_b_cyt 752..797) ---
--- cleavage 789 (inside Integrin_b_cyt 752..797) ---
--- cleavage 778 (inside Integrin_b_cyt 752..797) ---

3. Sequence Information

Fasta Sequence: XSB2208.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1K11 (Model; -; B=786-797), 1LHA (Model; -; A=86-543)

* Cleavage Information

4 [sites]

Cleavage sites (±10aa)

[Site 1] IYKSAVTTVV791-NPKYEGK

Val791 Asn

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ile782Tyr783Lys784Ser785Ala786Val787Thr788Thr789Val790Val791
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asn792Pro793Lys794Tyr795Glu796Gly797Lys798---

Sequence conservation (by blast)

[Site 2] KEKMNAKWDT777-GENPIYKSAV

Thr777 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys768Glu769Lys770Met771Asn772Ala773Lys774Trp775Asp776Thr777
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gly778Glu779Asn780Pro781Ile782Tyr783Lys784Ser785Ala786Val787

Sequence conservation (by blast)

[Site 3] NPIYKSAVTT789-VVNPKYEGK

Thr789 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asn780Pro781Ile782Tyr783Lys784Ser785Ala786Val787Thr788Thr789
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val790Val791Asn792Pro793Lys794Tyr795Glu796Gly797Lys798-

Sequence conservation (by blast)

[Site 4] EKMNAKWDTG778-ENPIYKSAVT

Gly778 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu769Lys770Met771Asn772Ala773Lys774Trp775Asp776Thr777Gly778
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu779Asn780Pro781Ile782Tyr783Lys784Ser785Ala786Val787Thr788

Sequence conservation (by blast)

* References

[PubMed ID: 2958481] Argraves WS, Suzuki S, Arai H, Thompson K, Pierschbacher MD, Ruoslahti E, Amino acid sequence of the human fibronectin receptor. J Cell Biol. 1987 Sep;105(3):1183-90.