XSB2214 : Chain A, Structure Of Cdk Inhibitor P19ink4d
[ CaMP Format ]
This entry is computationally expanded from SB0083
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Cyclin-dependent kinase 4 inhibitor D; p19-INK4d |
| Gene Names | CDKN2D |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| 1BD8_A | N/A | N/A | CDN2D_HUMAN | N/A | N/A | N/A | hsa:1032 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 156 aa
Average Mass: 16.605 kDa
Monoisotopic Mass: 16.595 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Ank 1. | 35 | 66 | 17.7 | 0.049 |
| --- cleavage 41 (inside Ank 35..66) --- | ||||
| --- cleavage 58 (inside Ank 35..66) --- | ||||
| Ank 2. | 67 | 99 | 27.7 | 4.9e-05 |
| Ank 3. | 100 | 131 | 15.6 | 0.21 |
| --- cleavage 107 (inside Ank 100..131) --- | ||||
| --- cleavage 121 (inside Ank 100..131) --- | ||||
3. Sequence Information
Fasta Sequence: XSB2214.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
* Cleavage Information
4 [sites]
Cleavage sites (±10aa)
[Site 1] LNRFGKTALQ41-VMMFGSTAIA
Gln41 
Val
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Leu32 | Asn33 | Arg34 | Phe35 | Gly36 | Lys37 | Thr38 | Ala39 | Leu40 | Gln41 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Val42 | Met43 | Met44 | Phe45 | Gly46 | Ser47 | Thr48 | Ala49 | Ile50 | Ala51 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| RGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDTSGTSP |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 120.00 | 26 | cyclin-dependent kinase inhibitor 2D |
| 2 | N/A | 120.00 | 25 | - |
| 3 | synthetic construct | 120.00 | 7 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 4 | Macaca mulatta | 120.00 | 5 | PREDICTED: cyclin-dependent kinase inhibitor 2D (p |
| 5 | Mus musculus | 115.00 | 35 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 6 | Rattus norvegicus | 115.00 | 14 | similar to cyclin-dependent kinase inhibitor 2D |
| 7 | Canis familiaris | 112.00 | 26 | PREDICTED: similar to Cyclin-dependent kinase 4 in |
| 8 | Bos taurus | 109.00 | 7 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 9 | Monodelphis domestica | 108.00 | 9 | PREDICTED: similar to Cyclin-dependent kinase inhi |
| 10 | Xenopus tropicalis | 99.00 | 2 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 11 | Xenopus laevis | 95.10 | 5 | ankyrin 2, neuronal |
| 12 | Xiphophorus maculatus | 68.60 | 2 | p19 |
| 13 | Tetraodon nigroviridis | 65.50 | 4 | unnamed protein product |
| 14 | Takifugu rubripes | 64.70 | 2 | p19 |
| 15 | Mesocricetus auratus | 53.50 | 3 | p15INK4b cyclin-dependent kinase inhibitor |
| 16 | Gallus gallus | 51.20 | 5 | PREDICTED: similar to Chain A, Crystal Structure O |
| 17 | Macaca fascicularis | 49.70 | 1 | unnamed protein product |
| 18 | Danio rerio | 48.10 | 9 | PREDICTED: similar to p13 |
| 19 | Sus scrofa | 47.80 | 2 | cyclin-dependent kinase inhibitor 2B |
| 20 | Pan troglodytes | 46.20 | 5 | PREDICTED: similar to p16-INK4 |
| 21 | human, brain tumors, Peptide, 156 aa | 46.20 | 1 | cyclin D-dependent kinases 4 and 6-binding protein |
| 22 | Xiphophorus helleri | 44.70 | 1 | p13CDKN2X |
| 23 | Myxococcus xanthus DK 1622 | 40.80 | 1 | ankyrin repeat protein |
| 24 | Apis mellifera | 39.30 | 2 | PREDICTED: similar to CG3104-PA, isoform A |
| 25 | Solibacter usitatus Ellin6076 | 38.90 | 1 | ankyrin-related protein |
| 26 | Drosophila melanogaster | 38.50 | 1 | CG3104-PA, isoform A |
| 27 | Tribolium castaneum | 38.10 | 2 | PREDICTED: similar to CG6896-PA |
| 28 | Trichomonas vaginalis G3 | 38.10 | 2 | hypothetical protein TVAG_185920 |
| 29 | Pseudomonas stutzeri A1501 | 38.10 | 1 | ankyrin domain protein |
| 30 | Medicago truncatula | 37.70 | 3 | Ankyrin |
| 31 | Equus caballus | 37.70 | 1 | cyclin-dependent kinase 2A inhibitor |
| 32 | Wolbachia endosymbiont of Culex pipiens | 37.00 | 1 | ankyrin domain protein ank12 |
| 33 | Aspergillus niger CBS 513.88 | 37.00 | 1 | hypothetical protein An10g00420 |
| 34 | Thermofilum pendens Hrk 5 | 36.60 | 1 | Ankyrin |
| 35 | Schistosoma japonicum | 36.60 | 1 | SJCHGC04635 protein |
| 36 | Methanosarcina barkeri str. fusaro | 36.20 | 1 | hypothetical protein Mbar_A2380 |
| 37 | Rickettsiella grylli | 35.80 | 2 | hypothetical protein Rgryl_01000812 |
| 38 | Ostreococcus lucimarinus CCE9901 | 35.80 | 1 | predicted protein |
| 39 | Cryptosporidium parvum Iowa II | 35.80 | 1 | conserved hypothetical protein |
| 40 | Aspergillus oryzae | 35.80 | 1 | unnamed protein product |
| 41 | Cryptosporidium parvum | 35.80 | 1 | acyl-CoA-binding protein |
| 42 | Cryptosporidium hominis TU502 | 35.80 | 1 | proteasome 26S subunit |
| 43 | Aedes aegypti | 35.40 | 1 | protein phosphatase 1 regulatory inhibitor subunit |
| 44 | Egeria densa | 35.40 | 1 | inward potassium channel alpha subunit |
| 45 | Anopheles gambiae str. PEST | 35.40 | 1 | ENSANGP00000028069 |
| 46 | Rickettsia felis URRWXCal2 | 35.40 | 1 | Ankyrin repeat |
| 47 | Caenorhabditis elegans | 35.00 | 7 | UNCoordinated family member (unc-44) |
| 48 | Orientia tsutsugamushi Boryong | 35.00 | 2 | ankyrin repeat protein with 5 ankyrin repeats |
| 49 | Caenorhabditis briggsae | 35.00 | 1 | Hypothetical protein CBG09456 |
| 50 | Dictyostelium discoideum AX4 | 34.70 | 1 | SecG |
| 51 | Leptospira borgpetersenii serovar Hardjo-bovis L550 | 34.70 | 1 | Ankyrin repeat protein |
| 52 | Bordetella pertussis Tohama I | 34.30 | 1 | hypothetical protein BP2881 |
| 53 | Bordetella parapertussis 12822 | 34.30 | 1 | hypothetical protein BPP0952 |
| 54 | Strongylocentrotus purpuratus | 33.90 | 5 | PREDICTED: similar to MGC80441 protein, partial |
| 55 | Orf virus | 33.90 | 1 | ORF126 ankyrin repeat protein |
| 56 | Neurospora crassa OR74A | 33.90 | 1 | hypothetical protein |
| 57 | Pseudomonas entomophila L48 | 33.90 | 1 | hypothetical protein PSEEN1535 |
| 58 | Aspergillus niger | 32.70 | 1 | hypothetical protein An08g11190 |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 |
| N/A | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 |
| synthetic construct | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 |
| Macaca mulatta | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 |
| Mus musculus | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 ||||||||||||||||||||||||||||||#|||||| |+||||||||||||||| ||||| Sbjct 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSPAVALELLKQGASPNVQDASGTSP 77 |
| Rattus norvegicus | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 ||||||||||||||||||||||||||||||#|||||| |+||||||||||||||| ||||| Sbjct 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSPAVALELLKQGASPNVQDASGTSP 77 |
| Canis familiaris | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 ||||||||||||||||||||||||||||||#|||||| |||||||||||||||| +||+| Sbjct 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSPTIALELLKQGASPNVQDATGTTP 77 |
| Bos taurus | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 |||||||||||| |||||| ||||||||||#|||||| |||||||||||||||| |||+| Sbjct 18 RGDVQEVRRLLHSELVHPDVLNRFGKTALQ#VMMFGSPTIALELLKQGASPNVQDASGTTP 77 |
| Monodelphis domestica | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 |||| |||||||+| ||||+||||||||||#||||||+ |||||||||||||||| ||||| Sbjct 18 RGDVNEVRRLLHQEFVHPDSLNRFGKTALQ#VMMFGSSPIALELLKQGASPNVQDGSGTSP 77 |
| Xenopus tropicalis | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 |||+ ||+|||| | +||| ||||||||||#||||||| +| ||||||||||+|| ||+| Sbjct 18 RGDLLEVKRLLHEERIHPDCLNRFGKTALQ#VMMFGSTPVASELLKQGASPNIQDAYGTTP 77 |
| Xenopus laevis | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 |||+ ||+|||| | +||| || |||||||#||||||| +| |||||||+||+|| ||+| Sbjct 18 RGDLTEVKRLLHEERIHPDCLNCFGKTALQ#VMMFGSTPVASELLKQGATPNIQDAYGTTP 77 |
| Xiphophorus maculatus | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 +|+ ||+|+| |||| | ||+||||#||| |++ +| ||++|| ||||| | +| Sbjct 18 KGNADEVQRILEECRVHPDTPNEFGRTALQ#VMMMGNSKVARLLLEKGAEPNVQDKHGIAP 77 |
| Tetraodon nigroviridis | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 +| ||||+| | || | |||||||#||| |+ || ||++|| ||||| | +| Sbjct 18 KGRTAEVRRILEECRVPPDTPNEFGKTALQ#VMMLGNCKIASLLLEKGADPNVQDKHGIAP 77 |
| Takifugu rubripes | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 +| ||+|+| | || | |||||||#||| |+ || ||++|| ||||| | +| Sbjct 18 KGRTSEVQRILEECRVPPDTRNEFGKTALQ#VMMLGNCKIASLLLEKGADPNVQDKHGIAP 77 |
| Mesocricetus auratus | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQD 65 || |+ ||+|| | |+|+||||+ +|#||| ||| +| || || || | Sbjct 16 RGQVETVRQLLEAG-VDPNAVNRFGRRPIQ#VMMMGSTQVAELLLLHGAEPNCAD 68 |
| Gallus gallus | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSG 68 +||+ ++ || + |+ +| | ||+||||#|| |+ || || ||+||++|++| Sbjct 15 KGDLVQLTNLLQKN-VNVNAQNGFGRTALQ#VMKLGNPEIARRLLMSGANPNLKDSTG 70 |
| Macaca fascicularis | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQD 65 || |++||+|| |+ +||||+ |+|#||| || +| || || || | Sbjct 24 RGLVEKVRQLLEAG-ADPNGVNRFGRRAIQ#VMMMGSARVAELLLLHGAEPNCAD 76 |
| Danio rerio | Query 13 GDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQD-TSGTSP 71 |++ |+ || |+ + +|+| +| +|#||| |+ +|| ||+||| ||| | +|++| Sbjct 15 GNISHVQFLLSNG-VNANVVNKFRRTPIQ#VMMMGNAPLALVLLEQGADPNVPDPDTGSTP 73 |
| Sus scrofa | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQD 65 || |+ ||+|| |+ || ||+ +|#||| || +| || || || | Sbjct 17 RGQVETVRQLLEAG-ADPNGLNHFGRRPIQ#VMMMGSARVAELLLLHGADPNCAD 69 |
| Pan troglodytes | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQD 65 || |+||| || + |+| | +|+ +|#||| || +| || || || | Sbjct 223 RGRVEEVRALLEAGAL-PNAPNSYGRRPIQ#VMMMGSARVAELLLLHGAEPNCAD 275 |
| human, brain tumors, Peptide, 156 aa | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQD 65 || |+||| || + |+| | +|+ +|#||| || +| || || || | Sbjct 22 RGRVEEVRALLEAVAL-PNAPNSYGRRPIQ#VMMMGSARVAELLLLHGAEPNCAD 74 |
| Xiphophorus helleri | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTS-GTS 70 +| || || + + +| ||+ |+|#||| ||+ +| || +|| ||| | | | + Sbjct 13 KGHTAEVEALLLQG-APVNGVNSFGRRAIQ#VMMMGSSEVARLLLTRGADPNVTDKSTGAT 71 Query 71 P 71 | Query 71 P 71 |
| Myxococcus xanthus DK 1622 | Query 21 LLHRELVHPDALNRFGKTALQ-#VMMFGSTAIALELLKQGASPNVQDTSGTS 70 |++++ | ||||+||| # +|| + +| +|||||+|+| || | Sbjct 127 LINQQPCAVDQSNRFGQTALMF#ASLFGRKEVVEQLRQQGASPDVRDGSGRS 177 |
| Apis mellifera | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIAL-ELLKQGASPNVQDTSGTS 70 ||| + +| || || | ++ | | | #+ | |+ |||+||| || + +||+ Sbjct 19 RGDAKRLRVLLDSGRVHVDCKDKDGTTPLI#LAAAGGHIEAVTELLQQGADPNARRLTGTT 78 |
| Solibacter usitatus Ellin6076 | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQ-GASPNVQDTSGTS 70 | | |+ ||| + +|+| ||+| | | #+ | +||| | || || | + Sbjct 62 RQDDLEMSRLLLKAGANPNAANRYGMTVLA#LACTNGNAAIVELLLQAGADPNAALPGGET 121 Query 71 P 71 | Query 71 P 71 |
| Drosophila melanogaster | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGS-TAIALELLKQGASPNVQDTSGTS 70 ||| + |+| || | + | | | #+ | | +||| ||| || + +||+ Sbjct 19 RGDEVALLRVLDSGKVHVDCKDEDGTTPLI#LAAAGGHTYCVMELLDQGADPNSRRLTGTT 78 Query 71 P 71 | Query 71 P 71 |
| Tribolium castaneum | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTAL-Q#VMMFGSTAIALELLKQGASPNVQDTSGTS 70 | |+ |||||| + | ||+ | | ||| |# + + |+ | ||+ |+ | +|+ + Sbjct 72 RNDIDEVRRLLMKG-VSPDSCNEDGLTALHQ#CCIDNNEAMLLLLLEYNANVNAEDSEKWT 130 Query 71 P 71 | Query 71 P 71 |
| Trichomonas vaginalis G3 | Query 20 RLLHRELVHP--------DALNRFGKTALQ#VMMFG-STAIALELLKQGASPNVQDTSG 68 || | ||| ||+| |+||| #| + ++ +| || |||||||| +| Sbjct 518 RLNHPSLVHALLEHDVNLDAINDEGQTALM#VAVVSWASEVAKLLLTFGASPNVQDKNG 575 |
| Pseudomonas stutzeri A1501 | Query 12 RGDVQEVRRLLHR--ELVHPDALNRFGKTALQ#VM-MFGSTAIALELLKQGASPNVQDTSG 68 +||+ || |+ | ++ | | ||||| #+ || ||| |+ ||| |+ | | Sbjct 93 KGDLPMVRLLVERGTDVESPCA---DGKTALM#MAAMFNHTAIVEWLVAQGADPHATDAGG 149 Query 69 TSP 71 |+| Sbjct 150 TTP 152 |
| Medicago truncatula | Query 30 DALNRFGKTALQ#VMMFGST-AIALELLKQGASPNVQDTSGTSP 71 |++|+ | ||| # + | |+ ||++||||++|| | +| Sbjct 183 DSINKEGLTALH#KAVIGKKEAVISHLLRKGASPHIQDKDGATP 225 |
| Equus caballus | Query 29 PDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQD 65 |+ +| ||+ +|#||| || +| || || || | Sbjct 5 PNGVNGFGRRPIQ#VMMMGSVHVAELLLLHGADPNRAD 41 |
| Wolbachia endosymbiont of Culex pipiens | Query 13 GDVQEVRRLLHRELVHPDALNRFGKTALQ-#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 | |+ | | | |+ + +|++| ||| # +| | ||++||+||+ + | | Sbjct 64 GGCLEIVRFLIDEGVNVNIINKYGSTALHN#AAYYGDLRIIKFLLEKGANPNIINDDGKKP 123 |
| Aspergillus niger CBS 513.88 | Query 13 GDVQEVRRLLHRELVHPDALNRFGKTAL-Q#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 || | +|| | |+ || |+ +| #|+ +|| | ||+ | |||+ | +| Sbjct 47 GDTNAVVKLLLRYGADPNIRNRHGRVSLFW#VLNYGSGASVEALLRAGCDPNVRYRYGRTP 106 |
| Thermofilum pendens Hrk 5 | Query 13 GDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 | + |+ || | | |++ || | | # + | + +| ||++|| || +++|| +| Sbjct 230 GSAEVVKFLLERG-ADPCAVDAFGNTPLH#-LAFKNMEVAKLLLEKGADPNAKNSSGMTP 286 |
| Schistosoma japonicum | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTAL-Q#VMMFGSTAIALELLKQGASPNVQDTSGTS 70 |||+ ||| || | || | | |+| |# + + + ||+ ||+|| +|| + Sbjct 94 RGDLDEVRELLSSG-VCPDVANEDGLTSLHQ#CCIDNNLEMCRLLLRYGANPNSRDTELWT 152 Query 71 P 71 | Query 71 P 71 |
| Methanosarcina barkeri str. fusaro | Query 13 GDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELL-KQGASPNVQDTSG 68 | ++ | + | + | ++ + +||||| # + +||| | || ||+|| +| Sbjct 23 GQIENVEKFLKSDKVDINSQDAYGKTALN#YAVNKGYRDVVELLIKGGADPNIQDENG 79 |
| Rickettsiella grylli | Query 16 QEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALE-LLKQGASPNVQDTSGTSP 71 ||+ |++ + | +| +|+| | # ++| +|++ |++||| | | +||+| Sbjct 211 QEMLEKLYQAGIPIDTVNNYGETPLF#SAIYGINPLAVKFFLERGASVNHQSVNGTTP 267 |
| Ostreococcus lucimarinus CCE9901 | Query 13 GDVQEVRRLLHRELVHPDALNRFGKTALQ#VMM-FGSTAIALELLKQGASPNVQDTSGTSP 71 ||+ || +| | | ++ |+||| # + || +| ||| +||+ +| | +| Sbjct 54 GDLLGVRAMLDARTVDVDDVDAGGRTALH#FAVGFGREHVARELLDRGAALETRDDWGKAP 113 |
| Cryptosporidium parvum Iowa II | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMF-GSTAIALELLKQGASPNVQDTSGTS 70 + +|+ ++++| | ++ + | || #+ | + ||| ||| ||+|||+| | | Sbjct 159 KNEVEFLKKILERYPFLSNSRSSEGSYALH#LACDKGYSEIALLLLKNGANPNVKDNFGDS 218 Query 71 P 71 | Query 71 P 71 |
| Aspergillus oryzae | Query 18 VRRLLHRELVHPDALNRFGKTALQ#V-MMFGSTAIALELLKQGASPNVQDTSGTSP 71 | ||| |+|+| | ||| #| +| |+ + |||++|| | + + +| | Sbjct 168 VMRLLLSYGADPNAVNSEGATALH#VGVMNGNYTMVAELLQRGADPTLTNAAGWLP 222 |
| Cryptosporidium parvum | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMF-GSTAIALELLKQGASPNVQDTSGTS 70 + +|+ ++++| | ++ + | || #+ | + ||| ||| ||+|||+| | | Sbjct 159 KNEVEFLKKILERYPFLSNSRSSEGSYALH#LACDKGYSEIALLLLKNGANPNVKDNFGDS 218 Query 71 P 71 | Query 71 P 71 |
| Cryptosporidium hominis TU502 | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMF-GSTAIALELLKQGASPNVQDTSGTS 70 + +|+ ++++| | ++ + | || #+ | + ||| ||| ||+|||+| | | Sbjct 159 KNEVEFLKKILERYPFLSNSRSSEGSYALH#LACDKGYSEIALLLLKNGANPNVKDNFGDS 218 Query 71 P 71 | Query 71 P 71 |
| Aedes aegypti | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALE-LLKQGASPNVQDTSGTS 70 | |+ || +|| + | ||| | | ||| # | | || ||+ | ||+ + Sbjct 86 RNDIAEVAKLLQKG-VTPDATNMDGLTALH#QCCIDDNAEMLNLLLDYGANVNAQDSERWT 144 Query 71 P 71 | Query 71 P 71 |
| Egeria densa | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMF-GSTAIALELLKQGASPNVQDTSGTS 70 ||| | +|| |+ + |+||| #+ || || || +||+|| +|+ |++ Sbjct 433 RGDYMLVDKLLECGS-DPNEADSKGRTALH#IAARNGSERCALLLLDRGANPNSKDSDGST 491 Query 71 P 71 | Query 71 P 71 |
| Anopheles gambiae str. PEST | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALE-LLKQGASPNVQDTSGTS 70 | |+ || +|| + | ||| | | ||| # | | || ||+ | ||+ + Sbjct 26 RNDIAEVAKLLQKG-VTPDATNMDGLTALH#QCCIDDNAEMLNLLLDYGANVNAQDSERWT 84 Query 71 P 71 | Query 71 P 71 |
| Rickettsia felis URRWXCal2 | Query 13 GDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMF-GSTAIALELLKQGASPNVQDTSG 68 ||+ ||+ || + + | |+||| # +| | | ||| ||||+ | || Sbjct 17 GDLSEVQALLKSGVNIDEHKNERGETALY#NTLFTGYMDRAAFLLKHKASPNIPDNSG 73 |
| Caenorhabditis elegans | Query 13 GDVQEVRRLLHRELVHPDALNRFGKTALQ#VM-MFGSTAIALELLKQGASPNVQDTSGTSP 71 | + || |+ |+ || | | ||| #+ + | + | |++ ||+ ||| +| +| Sbjct 77 GHSEVVRELIKRQ-AQVDAATRKGNTALH#IASLAGQSLIVTILVENGANVNVQSVNGFTP 135 |
| Orientia tsutsugamushi Boryong | Query 13 GDVQEVRRLLHRELVHPDALNRFGKTALQ#V-MMFGSTAIALELLKQGASPNVQDTSG 68 ||+++|++|++++ ++ + | ||| #| + + + || || ||+ | || | Sbjct 18 GDIEKVKQLINKDSTLVNSKYKDGTTALS#VALKYKNLPIAEILLNNGANVNAQDNDG 74 |
| Caenorhabditis briggsae | Query 13 GDVQEVRRLLHRELVHPDALNRFGKTALQ#VM-MFGSTAIALELLKQGASPNVQDTSGTSP 71 | + || |+ |+ || | | ||| #+ + | + | |++ ||+ ||| +| +| Sbjct 78 GHSEVVRELIKRQ-AQVDAATRKGNTALH#IASLAGQSLIVTILVENGANVNVQSVNGFTP 136 |
| Dictyostelium discoideum AX4 | Query 13 GDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMF-GSTAIALELLKQGASPNVQDTSGTSP 71 ||++++ ||+ || + +| | # | || | || + |+ |++|++| +| Sbjct 46 GDIEKLSNLLNNSATSPDTPDSEKRTPLH#HAAFCGSAACVNFLLDKKANANIKDSAGNTP 105 |
| Leptospira borgpetersenii serovar Hardjo-bovis L550 | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMF-GSTAIALELLKQGASPNVQDTSGTS 70 |||++ ++ + | | | || | | | #+ + | +| |+ ||| || | | | Sbjct 48 RGDIEALKAQIGT-LRHVDEKNRKGYTLLM#LAAYNGQEEASLFLISQGADPNSTDFEGNS 106 |
| Bordetella pertussis Tohama I | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTA-LQ#VMMFGS-----TAIALELLKQGASPNVQD 65 || |+ | || | | || +|| | | |+# ++ | || |++ || |+ | Sbjct 139 RGHVEVVDMLL-RAGVDPDHVNRLGWTGLLE#AIILGDGGTRHQAIVARLIEGGADVNLAD 197 Query 66 TSGTSP 71 | || Sbjct 198 GDGVSP 203 |
| Bordetella parapertussis 12822 | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTA-LQ#VMMFGS-----TAIALELLKQGASPNVQD 65 || |+ | || | | || +|| | | |+# ++ | || |++ || |+ | Sbjct 145 RGHVEVVDMLL-RAGVDPDHVNRLGWTGLLE#AIILGDGGTRHQAIVARLIEGGADVNLAD 203 Query 66 TSGTSP 71 | || Sbjct 204 GDGVSP 209 |
| Strongylocentrotus purpuratus | Query 33 NRFGKTALQ#VMMF-GSTAIALELLKQGASPNVQDTSGTSP 71 | |+||| #+ | + +|| |+ ||| |||| +| +| Sbjct 87 NERGETALH#MAAIKGDSQMALNLINQGAEVNVQDFAGWTP 126 |
| Orf virus | Query 21 LLHRELVHPDALNRFGKTALQ#VMMFG---STAIALELLKQGASPNVQDTSGTSP 71 || | +| + |+| | #+ + | | +|| |+ ||+|| | | +| Sbjct 136 LLAEHGAHVNAKDDLGRTPLH#IYLSGFFVSAPVALALIALGANPNATDAYGRTP 189 |
| Neurospora crassa OR74A | Query 30 DALNRFGKTAL-Q#VMMFGSTAIALELLKQGASPNVQDTSGTS 70 | |++|+||| |# + |+| |+++|| ||+|| | | Sbjct 939 DMANKYGETALMQ#AVSTRRWALAKLLIEKGADPNLQDGQGES 980 |
| Pseudomonas entomophila L48 | Query 12 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VM-MFGSTAIALELLKQGASPNVQDTSGTS 70 +||+ +| || | || |+||| #+ || | || ||| | +| +||+ Sbjct 93 KGDLAMIRLLLEHG-VPVDAAAADGRTALM#LAAMFNRLEILEHLLAQGADPAHRDAAGTT 151 |
| Aspergillus niger | Query 13 GDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMF-GSTAIALELLKQGASPNVQDTSGTSP 71 | + | +|| + |+ + |+| | # + | |+| ||+||| || ||+|| +| Sbjct 734 GGHEAVAKLLLEQGADPNTPDSSGRTPLS#RASWRGHEALAKLLLEQGADPNTQDSSGRTP 793 Query 16 QEVRRLLHRELVHPDALNRFGKTALQ#VMMF-GSTAIALELLKQGASPNVQDTSGTSP 71 + + +|| + |+ + |+| | # + | |+| ||+||| || ||+|| +| Sbjct 770 EALAKLLLEQGADPNTQDSSGRTPLS#RASWRGHEALAKLLLEQGADPNTQDSSGWTP 826 Query 13 GDVQEVRRLLHRELVHPDALNRFGKTAL-Q#VMMFGSTAIALELLKQGASPNVQDTSGTSP 71 | + | +|| |+| + |+| | # | |+| ||+||| || +|+|| +| Sbjct 668 GGHEAVAKLLLEWGADPNARDSSGQTLLIW#ASEKGHEAVAKLLLEQGADPNARDSSGWTP 727 Query 46 GSTAIALELLKQGASPNVQDTSGTSP 71 | |+| ||+||| || ||+|| | Sbjct 636 GHEAVAKLLLEQGADPNTQDSSGQIP 661 |
[Site 2] DGTGALPIHL107-AVQEGHTAVV
Leu107 Ala
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Asp98 | Gly99 | Thr100 | Gly101 | Ala102 | Leu103 | Pro104 | Ile105 | His106 | Leu107 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala108 | Val109 | Gln110 | Glu111 | Gly112 | His113 | Thr114 | Ala115 | Val116 | Val117 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| TGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARGLTPL |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 122.00 | 17 | - |
| 2 | Homo sapiens | 122.00 | 16 | cyclin-dependent kinase inhibitor 2D |
| 3 | synthetic construct | 122.00 | 10 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 4 | Macaca mulatta | 120.00 | 5 | PREDICTED: cyclin-dependent kinase inhibitor 2D (p |
| 5 | Canis familiaris | 115.00 | 6 | PREDICTED: similar to Cyclin-dependent kinase 4 in |
| 6 | Bos taurus | 112.00 | 8 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 7 | Monodelphis domestica | 107.00 | 4 | PREDICTED: similar to Cyclin-dependent kinase inhi |
| 8 | Mus musculus | 102.00 | 25 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 9 | Rattus norvegicus | 101.00 | 5 | similar to cyclin-dependent kinase inhibitor 2D |
| 10 | Xenopus tropicalis | 79.70 | 3 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 11 | Xenopus laevis | 78.60 | 1 | ankyrin 2, neuronal |
| 12 | Takifugu rubripes | 77.40 | 1 | p19 |
| 13 | Xiphophorus maculatus | 75.90 | 2 | p19 |
| 14 | Gallus gallus | 59.30 | 4 | PREDICTED: similar to Chain A, Crystal Structure O |
| 15 | Tetraodon nigroviridis | 59.30 | 3 | unnamed protein product |
| 16 | Danio rerio | 58.50 | 1 | PREDICTED: similar to Chain A, Structure Of P18ink |
| 17 | Arabidopsis thaliana | 53.50 | 3 | putative potassium transporter/channel |
| 18 | Apis mellifera | 52.80 | 2 | PREDICTED: similar to Ankyrin repeat and FYVE doma |
| 19 | Pan troglodytes | 50.80 | 5 | PREDICTED: huntingtin interacting protein 14 |
| 20 | Neosartorya fischeri NRRL 181 | 50.40 | 1 | Ankyrin repeat protein |
| 21 | Strongylocentrotus purpuratus | 49.70 | 104 | PREDICTED: similar to Zinc finger, DHHC domain con |
| 22 | Macaca fascicularis | 48.90 | 1 | unnamed protein product |
| 23 | Trichomonas vaginalis G3 | 47.80 | 11 | conserved hypothetical protein |
| 24 | Vitis vinifera | 47.80 | 1 | hypothetical protein |
| 25 | Canarypox virus | 47.00 | 1 | CNPV295 ankyrin repeat protein |
| 26 | Plasmodium berghei strain ANKA | 47.00 | 1 | hypothetical protein |
| 27 | Synechococcus sp. JA-2-3B'a(2-13) | 37.40 | 1 | ankyrin repeat protein |
| 28 | Tribolium castaneum | 36.20 | 1 | PREDICTED: similar to UNCoordinated family member |
| 29 | Neurospora crassa OR74A | 35.00 | 1 | hypothetical protein |
| 30 | Synechococcus sp. JA-3-3Ab | 34.70 | 1 | ankyrin repeat protein |
| 31 | Aspergillus nidulans FGSC A4 | 33.90 | 1 | hypothetical protein AN8767.2 |
| 32 | Xiphophorus helleri | 33.90 | 1 | p13CDKN2X |
| 33 | Wolbachia endosymbiont of Drosophila melanogaster | 33.50 | 1 | ankyrin repeat domain protein |
| 34 | Aspergillus terreus NIH2624 | 32.30 | 1 | predicted protein |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 137 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 137 |
| Homo sapiens | Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 137 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 137 |
| synthetic construct | Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 137 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 137 |
| Macaca mulatta | Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 137 |||||||||||||||||| |||||||||||#|||||||||||||||||||||||||||||| Sbjct 84 TGFLDTLKVLVEHGADVNAPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 143 |
| Canis familiaris | Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 137 |||||||||||||||||| |||||||||||#||+||||||||||| ||||| ||||||||| Sbjct 84 TGFLDTLKVLVEHGADVNAPDGTGALPIHL#AVREGHTAVVSFLATESDLHHRDARGLTPL 143 |
| Bos taurus | Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 137 |||||||||||||||||| |||||||||||#||+||||+|||||| ||||| ||| ||||| Sbjct 84 TGFLDTLKVLVEHGADVNAPDGTGALPIHL#AVREGHTSVVSFLATESDLHHRDATGLTPL 143 |
| Monodelphis domestica | Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 137 |||||||+||||||||||||||+|||||||#||+||| ||||||| |||| ||| ||||| Sbjct 84 TGFLDTLRVLVEHGADVNVPDGSGALPIHL#AVREGHAAVVSFLAGESDLQHRDAGGLTPL 143 |
| Mus musculus | Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 137 |||||||||||||||||| | ||+|||||#|++|||++|||||| ||||| ||| ||||| Sbjct 84 TGFLDTLKVLVEHGADVNALDSTGSLPIHL#AIREGHSSVVSFLAPESDLHHRDASGLTPL 143 |
| Rattus norvegicus | Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 137 |||||||||||||||||| | ||+|||||#|++|||++|||||| ||||| +|| ||||| Sbjct 84 TGFLDTLKVLVEHGADVNTLDSTGSLPIHL#AIREGHSSVVSFLAPESDLHHKDASGLTPL 143 |
| Xenopus tropicalis | Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTP 136 ||||||+|||+|||++| || +|+|||||#|++ || |+++|| ||| || | || Sbjct 85 GFLDTLQVLVQHGAEINTPDASGSLPIHL#ALKAGHVPVITYLALISDLQHRDREGHTP 142 |
| Xenopus laevis | Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTP 136 ||||||+|||+|||+|| || +|+|||||#|++ || |+++|| ||| + | | || Sbjct 85 GFLDTLQVLVQHGAEVNTPDASGSLPIHL#ALKAGHVPVITYLALISDLQQHDREGHTP 142 |
| Takifugu rubripes | Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLT 135 |||||||+||||+|| ||+|| +||||||+#|++||| || ||| ||| + | | Sbjct 84 TGFLDTLQVLVEYGASVNLPDQSGALPIHI#AIREGHRDVVEFLAPRSDLKHANKSGQT 141 |
| Xiphophorus maculatus | Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 137 ||||+||+||||||| ||+ | ||||||+#|++||| +| ||| ||| + | | + Sbjct 84 TGFLETLQVLVEHGASVNIQDQNGALPIHI#AIREGHRDIVEFLAPRSDLKHANVSGQTAI 143 |
| Gallus gallus | Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFL--AAESDLHRRDARGLTP 136 ||||||+ |+| ||||+ | | ||+||#| |||| || || | + ++ || | Sbjct 81 GFLDTLQTLLEFHADVNIEDAEGNLPLHL#AAQEGHVRVVEFLLRRTPSRVAHQNRRGDTA 140 Query 137 L 137 | Query 137 L 137 |
| Tetraodon nigroviridis | Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPI-HL#AVQEGHTAVVSFLA 121 |||||||+||||+|| ||+|| +||||| | # ++|| || ||| Sbjct 84 TGFLDTLQVLVEYGASVNLPDQSGALPIPHC#QSEKGHRDVVEFLA 128 |
| Danio rerio | Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE--SDLHRRDARGLTP 136 |+|||| || ++|||||+ | | ||+||#| +||| || || + +|+| || Sbjct 83 GYLDTLHVLAQNGADVNLLDNDGNLPLHL#AAREGHLDVVQFLVTHCVTQPFLANAKGYTP 142 |
| Arabidopsis thaliana | Query 81 LDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTP 136 || || ++++| || +||| | +| #|| ||| +| || + +|| |+ | || Sbjct 241 LDALKDIIKYGGDVTLPDGNGTTALHR#AVSEGHLEIVKFLLDQGADLDWPDSYGWTP 297 |
| Apis mellifera | Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLA--AESDLHRRDARGLTP 136 | ++ |+|| |||| | | |||+#|+| |+ ++| | ||+ || +|||| Sbjct 692 GLEQVIQTLIEHDADVNARDIEGKTPIHV#AIQNQHSQIISLLLYHPNIDLNIRDKKGLTP 751 |
| Pan troglodytes | Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTPL 137 | | + |+++||| ++ || | |||#| | |||++|++| |+ |+ | |+||| Sbjct 266 GHLSMVVQLMKYGADPSLIDGEGCSCIHL#AAQFGHTSIVAYLIAKGQDVDMMDQNGMTPL 325 |
| Neosartorya fischeri NRRL 181 | Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAES--DLHRRDARGLT 135 || ++ ++ |+ + +|| | | |+| #||++|| |||+ |+ |++| |+|| | Sbjct 200 TGDIEIIQRLLNYEYEVNTRDNRGRTPLHR#AVEKGHLAVVNLFLAQPNIDINRADSRGRT 259 Query 136 PL 137 |+ Sbjct 260 PM 261 |
| Strongylocentrotus purpuratus | Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTPL 137 | | + +|+++||| ++ || | |||#| | || +|++| |+ |++ | |+||| Sbjct 67 GHLPMVVLLMQYGADPSLRDGEGCSGIHL#ACQFAHTPIVAYLIAKGQDVNMIDGNGMTPL 126 |
| Macaca fascicularis | Query 87 LVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTPL 137 |+++||| ++ || | |||#| | |||++|++| |+ |+ | |+||| Sbjct 5 LMKYGADPSLIDGEGCSCIHL#AAQFGHTSIVAYLIAKGQDVDMMDQNGMTPL 56 |
| Trichomonas vaginalis G3 | Query 82 DTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAA-ESDLHRRDARGLTPL 137 || ++|++||||+|+ | | ||| #+||+ + + || +|++| + +| | | Sbjct 388 DTAEILLQHGADINIGDENGETPIHY#SVQKKNKEICEFLLQNNADVNRGNNKGQTAL 444 |
| Vitis vinifera | Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFL-AAESDLHRRDARGLTPL 137 | || +++| | ||||||| | |+ |#| +||| ++ | + ++ ++||| | | Sbjct 632 GDLDAVRLLTSRGYDVNVPDGDGYTPLML#AAREGHGSMCELLISCGANTEVKNARGETAL 691 |
| Canarypox virus | Query 80 FLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 137 | + |+||++| |+| | |++|+| #| ++ |+ | + ++++ |+ | ||| Sbjct 145 FYEMTKLLVDNGIDINCKDNYGSIPLHY#AAKKSELPVIDLLISNTNINSRNNRNNTPL 202 |
| Plasmodium berghei strain ANKA | Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLA-AESDLHRRDARGLT 135 |||| +| |++ ||++| | | +|+#| | ++ || | ++|+++| ||| Sbjct 251 GFLDIVKFLIKAGANINEEDSLGDSVLHI#AAYSGKMEIIKFLINAGVNIHKKNAEGLT 308 |
| Synechococcus sp. JA-2-3B'a(2-13) | Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVS-FLAAESDLHRRDARGLTPL 137 | |+ | +|+ ||| | | ||| |+||#| | +| | | ||+ | | ||| Sbjct 45 GDLELLDLLLAHGASPNALDPTGATPLHL#AAAVGQVKLVERLLRAGSDIDLPDNHGYTPL 104 Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTPL 137 | | + |+ +||+ | + || |+| #| ||| ++ | ++|+ |+ | ||| Sbjct 170 GDLGIARFLLLYGANANARNRFGATPMHW#AAWEGHIEILELLLENGAELNPRNEDGHTPL 229 |
| Tribolium castaneum | Query 81 LDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTPL 137 |+ | |++ |||+| || +|| |+| #||+ ++ | + +|++|+| | ||| Sbjct 126 LELCKFLIDSGADLNAPDSSGATPLHY#AVELNFPKIILLLVHKGADVNRQDLDGYTPL 183 Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLA-AESDLHRRDARGLTPL 137 | | |+||++ ||+ + | +||#| ++ + || + +||+ |+ | ||| Sbjct 91 GNLSLAKLLVKNNADLQITDTNSRSLLHL#AAEKNSLELCKFLIDSGADLNAPDSSGATPL 150 |
| Neurospora crassa OR74A | Query 81 LDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVV-SFLAAESDLHRRDARGLTPL 137 ++|+|+| |||+ |+|| || +|+| #|| | | | +|++ | ||| Sbjct 264 VETVKILCSHGANPNLPDETGHMPLHQ#AVHSVHLAAAKQLLDCGADINAATKSGRTPL 321 Query 82 DTLKVLVEHGADVNVPDG-TGALPIHL#AVQEGHTAVVSFL-AAESDLHRRDARGLTPL 137 + +++|+ ||||+| || |+|+#| | || +| | | + + ||||| Sbjct 397 ELVELLLARGADVHVASSSTGMTPLHV#ACQGGHEGIVGMLIRAGMPVDGVNKDGLTPL 454 Query 81 LDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 137 | | |++ |||+| +| |++|#|+ + | +|| | + | ||| Sbjct 297 LAAAKQLLDCGADINAATKSGRTPLYL#AIAKRSTDIVSVLCERGAVINRRVGDSTPL 353 |
| Synechococcus sp. JA-3-3Ab | Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVS-FLAAESDLHRRDARGLTPL 137 | |+ | +|+ +|| |+ | ||| |+||#| | || | | ||+ | | ||| Sbjct 45 GNLELLDLLLAYGASVDSMDSTGATPLHL#AAASGQVEVVERLLKAGSDIDLLDRYGYTPL 104 Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTPL 137 | | + |+ +||||| + || |+| #| ||| ++ | ++|+ |+ | ||| Sbjct 170 GHLGIARFLILYGADVNARNRFGATPMHW#AAWEGHIQILELLLENGAELNPRNHDGHTPL 229 Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAA-ESDLHRRDARGLTP 136 || | |+ || |+ | || |+| #| +|| + || +|++ |+ | || Sbjct 136 TGRKSVLARLLSKGAPVDAVDETGRTPLHE#AATQGHLGIARFLILYGADVNARNRFGATP 195 Query 137 L 137 + Sbjct 196 M 196 Query 84 LKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAA-ESDLHRRDARGLTPL 137 | ++ | || || | |+| #|| |+ ++ | | + + |+ | ||| Sbjct 17 LLAYLQQGGHVNAPDSQGFTPLHK#AVLIGNLELLDLLLAYGASVDSMDSTGATPL 71 |
| Aspergillus nidulans FGSC A4 | Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTPL 137 | ++ |+| |||||+|| | |+ #||+ || ||| | |+ + | | ||| Sbjct 93 GHTGVVRRLLESGADVNIPDSKGQTPLSW#AVENGHQAVVQLLLGHGSNPNTPDPGGQTPL 152 Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDL--HRRDARGLTP 136 | +++|+ ||++ | || | |+ #|| +|+ +| | + ||| + |||| Sbjct 126 GHQAVVQLLLGHGSNPNTPDPGGQTPLSC#AVSKGNQEIVKLLLSSSDLECNTPHPNGLTP 185 Query 137 L 137 | Query 137 L 137 Query 82 DTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAES-DLHRRDARGLTPL 137 | +||+||||| | | |+| #| | + | + |+ + | ||| Sbjct 672 DIAEVLLEHGADPEAQDSHGDAPLHF#AAASGRRKMAELLLDKGVDIDITNYTGDTPL 728 Query 85 KVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTPL 137 ++|++ | |+++ + || |+| #| || +| || + + | |+ ||| Sbjct 708 ELLLDKGVDIDITNYTGDTPLHK#AASNGHRKMVEFLLSRGATLEIRNDYRQTPL 761 Query 81 LDTLKVLVEHGADVNVPDGTGALPIHL#A-VQEGHTAVVSFLAAESDLHRRDARGLTPL 137 |+ + ||+||||+++ || |+| #| + | | +| +|+ | || Sbjct 638 LELMNVLMEHGAEIDSVTEEGATPLHQ#AIINEREDIAEVLLEHGADPEAQDSHGDAPL 695 |
| Xiphophorus helleri | Query 78 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFL 120 ||||||+++||| ||| | ||| |#| | ||| ||+ | Sbjct 79 TGFLDTVQLLVEAGADPQARDKDNCLPIDL#ARQNGHTDVVAVL 121 Query 79 GFLDTLKVLVEHGADVNVPD-GTGALPIHL#AVQEGHTAVVSFLA-AESDLHRRDARGLTP 136 | + ++|+ ||| || | ||| |+| #| + | | | | +| || | Sbjct 46 GSSEVARLLLTRGADPNVTDKSTGATPLHD#AARTGFLDTVQLLVEAGADPQARDKDNCLP 105 Query 137 L 137 + Sbjct 106 I 106 |
| Wolbachia endosymbiont of Drosophila melanogaster | Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTPL 137 | ++ +| |++ |||||| | |+| #| + ||| || | + +|++ +| | ||| Sbjct 190 GHIEVVKHLIKKGADVNVQSKVGRTPLHN#AAKHGHTQVVEVLLKKGADVNIQDRGGRTPL 249 Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFL----AAESDLHRRDA 131 | ++||++ |||||+ | | |+| #||| + + | | | +|| | Sbjct 223 GHTQVVEVLLKKGADVNIQDRGGRTPLHY#AVQRRYPKLAKLLLNDGADPSFIHRSKA 279 Query 79 GFLDTLKVLVEHGADVNVPDG-TGALPIHL#AVQEGHTAVVSFLA-AESDLHRRDARGLTP 136 | + ++ |+++|| + +| |+|+#| + || +| |+ |+|+ ++ | || Sbjct 90 GHIQIVENLLDNGAKTGIKNGYCKEAPLHV#AAKHGHIRIVEILSKKEADIDLKNRYGETP 149 Query 137 L 137 | Query 137 L 137 Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVV-SFLAAESDLHRRDARGLTPL 137 | + +++| + ||+++ + | |+| #| + ||| |+ + | ++++ + | ||| Sbjct 124 GHIRIVEILSKKEADIDLKNRYGETPLHY#AAKYGHTQVLENLLGRSTNVNVQSEVGRTPL 183 Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTPL 137 | |+ |+ +||| | |+| #| || || | + +|++ + | ||| Sbjct 157 GHTQVLENLLGRSTNVNVQSEVGRTPLHD#AANNGHIEVVKHLIKKGADVNVQSKVGRTPL 216 |
| Aspergillus terreus NIH2624 | Query 79 GFLDTLKVLVEHGADVNVP-DGTGALPIHL#AVQEGHTAVVS-FLAAESDLHRRDARGLTP 136 | + + |+|+|||||| +|+ |+||#| | || |+| | |+| + | |||| Sbjct 643 GSREMVYTLIENGADVNVKGQKSGSTPLHL#ACQYGHGDVISLLLEKEADPNAEDETGLTP 702 Query 137 L 137 | Query 137 L 137 Query 79 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVS-FLAAESDLHRRDARGLTPL 137 | + +++|+ | ++ | |++|#| || ||| ++ ++|| | | |+ Sbjct 1375 GRWEIVQILLRSNAAIDAQDSKKRTPLYL#ATYHGHFEVVSALISRNANLHLADEDGWEPV 1434 Query 78 TGFLDTLKVLVEHGADVNVP------------DGTGALPIHL#AVQEGHTAVV-SFLAAES 124 || || |+++ | | | ||| |+| #| || || + |+ | Sbjct 738 TGRLDIFKLILHHCTQTKGPENEDDCVVLSNRDETGATPLHR#AASGGHAEVVRALLSLEK 797 Query 125 D 125 | Query 125 D 125 |
[Site 3] AIALELLKQG58-ASPNVQDTSG
Gly58 Ala
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ala49 | Ile50 | Ala51 | Leu52 | Glu53 | Leu54 | Leu55 | Lys56 | Gln57 | Gly58 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala59 | Ser60 | Pro61 | Asn62 | Val63 | Gln64 | Asp65 | Thr66 | Ser67 | Gly68 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| PDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLV |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 119.00 | 29 | cyclin-dependent kinase inhibitor 2D |
| 2 | N/A | 119.00 | 21 | - |
| 3 | synthetic construct | 119.00 | 10 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 4 | Macaca mulatta | 119.00 | 7 | PREDICTED: cyclin-dependent kinase inhibitor 2D (p |
| 5 | Mus musculus | 114.00 | 38 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 6 | Rattus norvegicus | 114.00 | 8 | similar to cyclin-dependent kinase inhibitor 2D |
| 7 | Monodelphis domestica | 109.00 | 12 | PREDICTED: similar to Cyclin-dependent kinase inhi |
| 8 | Bos taurus | 109.00 | 8 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 9 | Canis familiaris | 109.00 | 7 | PREDICTED: similar to Cyclin-dependent kinase 4 in |
| 10 | Xenopus tropicalis | 102.00 | 4 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 11 | Xenopus laevis | 97.80 | 6 | ankyrin 2, neuronal |
| 12 | Takifugu rubripes | 86.70 | 2 | p19 |
| 13 | Tetraodon nigroviridis | 86.30 | 6 | unnamed protein product |
| 14 | Xiphophorus maculatus | 82.40 | 2 | p19 |
| 15 | Danio rerio | 71.20 | 2 | PREDICTED: similar to p13 |
| 16 | Xiphophorus helleri | 71.20 | 1 | p13CDKN2X |
| 17 | Mesocricetus auratus | 69.70 | 3 | p15INK4b cyclin-dependent kinase inhibitor |
| 18 | Gallus gallus | 68.20 | 7 | PREDICTED: similar to Chain A, Crystal Structure O |
| 19 | Macaca fascicularis | 68.20 | 1 | unnamed protein product |
| 20 | Sus scrofa | 67.80 | 4 | cyclin dependant kinase inhibitor |
| 21 | Pan troglodytes | 62.80 | 9 | PREDICTED: similar to p16-INK4 |
| 22 | human, brain tumors, Peptide, 156 aa | 62.80 | 1 | cyclin D-dependent kinases 4 and 6-binding protein |
| 23 | Equus caballus | 53.90 | 1 | cyclin-dependent kinase 2A inhibitor |
| 24 | Felis catus | 51.20 | 2 | p16/CDKN2A/MTS1 |
| 25 | Medicago truncatula | 49.70 | 1 | Ankyrin |
| 26 | Mus spretus | 49.30 | 1 | cyclin-dependent kinase inhibitor protein |
| 27 | Strongylocentrotus purpuratus | 48.50 | 7 | PREDICTED: similar to MGC80441 protein, partial |
| 28 | Arabidopsis thaliana | 45.40 | 1 | EMB506 (EMBRYO DEFECTIVE 506); protein binding |
| 29 | Vitis vinifera | 45.40 | 1 | hypothetical protein |
| 30 | Oryza sativa (japonica cultivar-group) | 43.90 | 3 | hypothetical protein OsJ_019894 |
| 31 | Ustilago maydis 521 | 43.90 | 1 | hypothetical protein UM02100.1 |
| 32 | Rattus sp. | 43.90 | 1 | AAP31998.1 |
| 33 | Oryza sativa (indica cultivar-group) | 43.90 | 1 | hypothetical protein OsI_021528 |
| 34 | Theileria annulata strain Ankara | 43.50 | 1 | hypothetical protein TA20480 |
| 35 | Aedes aegypti | 43.10 | 4 | ankyrin repeat domain |
| 36 | Ashbya gossypii ATCC 10895 | 43.10 | 1 | ADL244Wp |
| 37 | Drosophila melanogaster | 43.10 | 1 | CG3104-PA, isoform A |
| 38 | Tribolium castaneum | 42.70 | 1 | PREDICTED: similar to CG18247-PA |
| 39 | Dictyostelium discoideum | 42.70 | 1 | homeobox-containing protein Wariai |
| 40 | Dictyostelium discoideum AX4 | 42.70 | 1 | putative homeobox transcription factor |
| 41 | Treponema denticola ATCC 35405 | 42.70 | 1 | ankyrin repeat protein |
| 42 | Neosartorya fischeri NRRL 181 | 42.70 | 1 | Ankyrin repeat protein |
| 43 | Aspergillus fumigatus Af293 | 42.40 | 1 | ankyrin repeat protein |
| 44 | Anopheles gambiae str. PEST | 42.00 | 4 | ENSANGP00000004013 |
| 45 | Trichomonas vaginalis G3 | 42.00 | 3 | hypothetical protein TVAG_580310 |
| 46 | Samanea saman | 42.00 | 1 | pulvinus inward-rectifying channel for potassium S |
| 47 | Myxococcus xanthus DK 1622 | 42.00 | 1 | ankyrin repeat protein |
| 48 | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 | 41.60 | 1 | putative ankyrin-repeat containing protein |
| 49 | Aspergillus oryzae | 41.20 | 1 | unnamed protein product |
| 50 | Apis mellifera | 37.40 | 1 | PREDICTED: similar to no mechanoreceptor potential |
| 51 | Hemicentrotus pulcherrimus | 35.80 | 1 | inv-like protein |
| 52 | Rickettsiella grylli | 35.80 | 1 | hypothetical protein Rgryl_01000336 |
| 53 | Wolbachia endosymbiont of Drosophila melanogaster | 35.40 | 1 | ankyrin repeat domain protein |
| 54 | Caenorhabditis briggsae | 35.00 | 2 | Hypothetical protein CBG13617 |
| 55 | Wolbachia pipientis | 34.70 | 1 | ankyrin domain protein |
| 56 | Wolbachia endosymbiont of Drosophila willistoni TSC#14030-0811.24 | 34.70 | 1 | hypothetical protein Wendoof_01000724 |
| 57 | Caenorhabditis elegans | 33.10 | 8 | TRP (transient receptor potential) channel family |
| 58 | Thermofilum pendens Hrk 5 | 32.70 | 1 | Ankyrin |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 |
| N/A | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 |
| synthetic construct | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 |
| Macaca mulatta | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 |
| Mus musculus | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 ||||||||||||||||||| |+||||||||#||||||| |||||||||||||||||||||| Sbjct 35 PDALNRFGKTALQVMMFGSPAVALELLKQG#ASPNVQDASGTSPVHDAARTGFLDTLKVLV 94 |
| Rattus norvegicus | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 ||||||||||||||||||| |+||||||||#||||||| |||||||||||||||||||||| Sbjct 35 PDALNRFGKTALQVMMFGSPAVALELLKQG#ASPNVQDASGTSPVHDAARTGFLDTLKVLV 94 |
| Monodelphis domestica | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 ||+||||||||||||||||+ |||||||||#||||||| ||||| ||||||||||||+||| Sbjct 35 PDSLNRFGKTALQVMMFGSSPIALELLKQG#ASPNVQDGSGTSPAHDAARTGFLDTLRVLV 94 |
| Bos taurus | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 || |||||||||||||||| |||||||||#||||||| |||+| |||||||||||||||| Sbjct 35 PDVLNRFGKTALQVMMFGSPTIALELLKQG#ASPNVQDASGTTPAHDAARTGFLDTLKVLV 94 |
| Canis familiaris | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 ||||||||||||||||||| |||||||||#||||||| +||+| |||||||||||||||| Sbjct 35 PDALNRFGKTALQVMMFGSPTIALELLKQG#ASPNVQDATGTTPAHDAARTGFLDTLKVLV 94 |
| Xenopus tropicalis | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 || ||||||||||||||||| +| ||||||#||||+|| ||+| ||||| ||||||+||| Sbjct 35 PDCLNRFGKTALQVMMFGSTPVASELLKQG#ASPNIQDAYGTTPAHDAARCGFLDTLQVLV 94 |
| Xenopus laevis | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 || || |||||||||||||| +| ||||||#|+||+|| ||+| ||||| ||||||+||| Sbjct 35 PDCLNCFGKTALQVMMFGSTPVASELLKQG#ATPNIQDAYGTTPAHDAARCGFLDTLQVLV 94 |
| Takifugu rubripes | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 || | |||||||||| |+ || ||++|#| ||||| | +||||||||||||||+||| Sbjct 35 PDTRNEFGKTALQVMMLGNCKIASLLLEKG#ADPNVQDKHGIAPVHDAARTGFLDTLQVLV 94 |
| Tetraodon nigroviridis | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 || | |||||||||| |+ || ||++|#| ||||| | +||||||||||||||+||| Sbjct 35 PDTPNEFGKTALQVMMLGNCKIASLLLEKG#ADPNVQDKHGIAPVHDAARTGFLDTLQVLV 94 |
| Xiphophorus maculatus | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 || | ||+||||||| |++ +| ||++|#| ||||| | +||||||+||||+||+||| Sbjct 35 PDTPNEFGRTALQVMMMGNSKVARLLLEKG#AEPNVQDKHGIAPVHDAAQTGFLETLQVLV 94 |
| Danio rerio | Query 30 DALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQD-TSGTSPVHDAARTGFLDTLKVLV 88 + +|+| +| +|||| |+ +|| ||+||#| ||| | +|++|+||||||||+||+++|+ Sbjct 31 NVVNKFRRTPIQVMMMGNAPLALVLLEQG#ADPNVPDPDTGSTPLHDAARTGFIDTVRLLI 90 |
| Xiphophorus helleri | Query 30 DALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTS-GTSPVHDAARTGFLDTLKVLV 88 + +| ||+ |+|||| ||+ +| || +|#| ||| | | | +|+|||||||||||+++|| Sbjct 30 NGVNSFGRRAIQVMMMGSSEVARLLLTRG#ADPNVTDKSTGATPLHDAARTGFLDTVQLLV 89 |
| Mesocricetus auratus | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSG-TSPVHDAARTGFLDTLKVL 87 |+|+||||+ +|||| ||| +| || |#| || | + | ||||||| |||||| || Sbjct 32 PNAVNRFGRRPIQVMMMGSTQVAELLLLHG#AEPNCADPNTLTRPVHDAAREGFLDTLVVL 91 |
| Gallus gallus | Query 30 DALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 +| | ||+|||||| |+ || || |#|+||++|++| + +|| || ||||||+ |+ Sbjct 32 NAQNGFGRTALQVMKLGNPEIARRLLMSG#ANPNLKDSTGFAVIHDVARAGFLDTLQTLL 90 |
| Macaca fascicularis | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSG-TSPVHDAARTGFLDTLKVL 87 |+ +||||+ |+|||| || +| || |#| || | + | ||||||| |||||| || Sbjct 40 PNGVNRFGRRAIQVMMMGSARVAELLLLHG#AEPNCADPATLTRPVHDAAREGFLDTLVVL 99 |
| Sus scrofa | Query 30 DALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSG-TSPVHDAARTGFLDTLKVL 87 +| ||+|+| +|||| ||| +| || |#| || +| + | ||||||| |||||| || Sbjct 31 NAPNRYGRTPIQVMMMGSTRVAELLLLHG#ADPNCEDPATLTRPVHDAAREGFLDTLVVL 89 |
| Pan troglodytes | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSG-TSPVHDAARTGFLDTLKVL 87 |+| | +|+ +|||| || +| || |#| || | + | ||||||| |||||| || Sbjct 239 PNAPNSYGRRPIQVMMMGSARVAELLLLHG#AEPNCADPATLTRPVHDAAREGFLDTLVVL 298 |
| human, brain tumors, Peptide, 156 aa | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSG-TSPVHDAARTGFLDTLKVL 87 |+| | +|+ +|||| || +| || |#| || | + | ||||||| |||||| || Sbjct 38 PNAPNSYGRRPIQVMMMGSARVAELLLLHG#AEPNCADPATLTRPVHDAAREGFLDTLVVL 97 |
| Equus caballus | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSG-TSPVHDAARTGFL 81 |+ +| ||+ +|||| || +| || |#| || | | ||||||| ||| Sbjct 5 PNGVNGFGRRPIQVMMMGSVHVAELLLLHG#ADPNRADPDTLTRPVHDAAREGFL 58 |
| Felis catus | Query 42 VMMFGSTAIALELLKQG#ASPNVQDTSG-TSPVHDAARTGFLDTLKVL 87 ||| || +| || |#| || | + | ||||||| |||||| || Sbjct 1 VMMMGSARVAELLLLHG#ADPNCADPATLTRPVHDAAREGFLDTLVVL 47 |
| Medicago truncatula | Query 30 DALNRFGKTALQVMMFGST-AIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 |++|+ | ||| + | |+ ||++|#|||++|| | +|+| | | |+|+|+ Sbjct 183 DSINKEGLTALHKAVIGKKEAVISHLLRKG#ASPHIQDKDGATPLHYAVEVGAKQTVKLLI 242 |
| Mus spretus | Query 42 VMMFGSTAIALELLKQG#ASPNVQD-TSGTSPVHDAARTGFLDTLKVL 87 ||| |+ +| || |#| | +| |+ + ||||||| |||||| || Sbjct 1 VMMMGNVHVAALLLNYG#ADSNCEDPTTFSRPVHDAAREGFLDTLVVL 47 |
| Strongylocentrotus purpuratus | Query 33 NRFGKTALQVMMF-GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | |+||| + | + +|| |+ ||#| |||| +| +|+|+| |+ + |||+ Sbjct 87 NERGETALHMAAIKGDSQMALNLINQG#AEVNVQDFAGWTPLHEACNHGYYEVAKVLI 143 |
| Arabidopsis thaliana | Query 30 DALNRFGKTALQVMMFGST-AIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVL 87 | +++ +||| + | |+ ||++|#|+|++|| | +|+| | + | | |+|+| Sbjct 179 DDVDKDNQTALHKAIIGKKEAVISHLLRKG#ANPHLQDRDGAAPIHYAVQVGALQTVKLL 237 |
| Vitis vinifera | Query 30 DALNRFGKTALQVMMFGST-AIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | +++ | ||| + | |+ ||++|#|+|+|+| | +|+| | + | + |+|+|+ Sbjct 185 DNVDKDGLTALHRAIIGKKEAVISHLLRKG#ANPHVRDRDGATPLHYAVQVGAMQTVKLLI 244 |
| Oryza sativa (japonica cultivar-group) | Query 32 LNRFGKTALQVMMFGST-AIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 |++ | | | + | |+ ||++|#|+|+|+| | +|+| | + | | |+|+|+ Sbjct 165 LDKDGFTPLHKAVIGKKEAVISHLLRRG#ANPHVRDRDGATPLHYAVQVGALQTVKLLI 222 |
| Ustilago maydis 521 | Query 33 NRFGKTAL-QVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 +| |+||| + | | ++| || |#| | || | + +|+| |+|| +++|| Sbjct 398 DREGETALHKAAMAGKLSVASLLLSHG#ADANAQDADGWTALHNACSRGYLDLVRLLV 454 |
| Rattus sp. | Query 43 MMFGSTAIALELLKQG#ASPNVQDTSG-TSPVHDAARTGFLD 82 || || +| || |#| || | + | ||||||| |||| Sbjct 1 MMMGSAQVAELLLLHG#AEPNCADPATLTRPVHDAAREGFLD 41 |
| Oryza sativa (indica cultivar-group) | Query 32 LNRFGKTALQVMMFGST-AIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 |++ | | | + | |+ ||++|#|+|+|+| | +|+| | + | | |+|+|+ Sbjct 165 LDKDGFTPLHKAVIGKKEAVISHLLRRG#ANPHVRDRDGATPLHYAVQVGALQTVKLLI 222 |
| Theileria annulata strain Ankara | Query 46 GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 |+| + +||+ |#| ||+ |+ | +|+| |+ +|+| |+|+ Sbjct 253 GNTGLVKKLLENG#ADPNICDSQGWTPLHCASESGYLSVCKLLI 295 |
| Aedes aegypti | Query 46 GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | || +|||+||#| || + +||+ + ||+ ||+| ++|+ Sbjct 22 GHTACVIELLEQG#ADPNARRVTGTTALFFAAQGGFVDVARILL 64 |
| Ashbya gossypii ATCC 10895 | Query 36 GKTALQVMMF-GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 |+| ||| | +| +|+++|# | || +| ||+|+|| | |+ +|+|+ Sbjct 341 GRTRLQVACDKGKYDLARKLIEEG#YDVNDQDNAGNSPLHEAALNGHLEVVKLLI 394 |
| Drosophila melanogaster | Query 46 GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | | +||| ||#| || + +||+|+ ||+ | || +|+|+ Sbjct 54 GHTYCVMELLDQG#ADPNSRRLTGTTPLFFAAQGGHLDVVKILI 96 |
| Tribolium castaneum | Query 30 DALNRFGKTALQVM-MFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 +| |+ |+||+ + | | | +|+ |#|| |++||+| +|+| | + | |+++|| Sbjct 145 EAKNQNGQTAVHLASMNGKDDILRKLIDYG#ASVNLRDTAGYTPLHYACQNNFPSTVRLLV 204 |
| Dictyostelium discoideum | Query 30 DALNRFGKTALQVM-MFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 +|++ | | | + | | ||+ |#| ||+||+ | +|+| | | ++|+| |+ Sbjct 532 NAIDIDGHTPLHTSSLMGQYLITRLLLENG#ADPNIQDSEGYTPIHYAVRESRIETVKFLI 591 |
| Dictyostelium discoideum AX4 | Query 30 DALNRFGKTALQVM-MFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 +|++ | | | + | | ||+ |#| ||+||+ | +|+| | | ++|+| |+ Sbjct 535 NAIDIDGHTPLHTSSLMGHDLITRLLLENG#ADPNIQDSEGYTPIHYAVRESRIETVKFLI 594 |
| Treponema denticola ATCC 35405 | Query 29 PDALNRFGKTALQVMMFGSTAIAL--ELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTL 84 |++ | | ||| ++| ++ | ||+ |#|+||++| | +|+| ||| | | + Sbjct 307 PNSRNSSGNTALHLVMPEASRSKLFNELITAG#ANPNLKDNYGETPLHVAARIGMNDDI 364 |
| Neosartorya fischeri NRRL 181 | Query 45 FGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 || | || |#| ||| | ||++ ||+ | | ++|||| Sbjct 303 FGHPDAVLALLHHG#ADPNVPSVDGQSPIYSAAKLGQLSSVKVLV 346 |
| Aspergillus fumigatus Af293 | Query 45 FGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 || | || |#| ||| | ||++ ||+ | | ++|||| Sbjct 302 FGHPDAVLALLHHG#ADPNVPSVDGQSPIYSAAKLGQLGSVKVLV 345 |
| Anopheles gambiae str. PEST | Query 46 GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | || +|||+||#| || + +||+ + ||+ |++| ++|+ Sbjct 13 GHTACVIELLEQG#ADPNARRVTGTTALFFAAQGGYVDVARILL 55 |
| Trichomonas vaginalis G3 | Query 30 DALNRFGKTALQVMMF-GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 ++ + ||| | + | ||| |||||#| || +| | +|+ ||+ | | + +|| Sbjct 474 NSADNMGKTCLLLAAASGHTAIVDFLLKQG#AEPNAKDREGFTPLLAAAQNGRTDCVSLLV 533 |
| Samanea saman | Query 40 LQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | | |+ | |||| |# |+| |+ | +|+| || | | +|||+ Sbjct 548 LTVASTGNAAFLEELLKAG#LDPDVGDSKGKTPLHIAASNGHEDCVKVLL 596 |
| Myxococcus xanthus DK 1622 | Query 30 DALNRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAART 78 | ||||+||| +|| + +| +||#|||+|+| || | | ||| Sbjct 136 DQSNRFGQTALMFASLFGRKEVVEQLRQQG#ASPDVRDGSGRS-AQDWART 184 |
| Legionella pneumophila subsp. pneumophila str. Philadelphia 1 | Query 32 LNRFGKTALQ------VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLK 85 ||+ || | +| | | |+| |#|| ++|| || ||+| | + | +|+| Sbjct 462 LNKKDKTGNQYTALHWAVMQGHLDCARLLVKSG#ASVDIQDKSGKSPLHYAIKRGDKETIK 521 Query 86 VLV 88 +|| Sbjct 522 LLV 524 |
| Aspergillus oryzae | Query 29 PDALNRFGKTALQV-MMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTG 79 |+|+| | ||| | +| |+ + |||++|#| | + + +| |+| | | Sbjct 179 PNAVNSEGATALHVGVMNGNYTMVAELLQRG#ADPTLTNAAGWLPLHQAVHAG 230 |
| Apis mellifera | Query 33 NRFGKTALQVMM-FGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 +|+||| | + | + || ||#| | | +| +|+| ||| |+|| +|+|| Sbjct 1025 DRYGKTGLHIAATHGHYQMVEVLLGQG#AEINATDKNGWTPLHCAARAGYLDVVKLLV 1081 Query 51 ALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 || ||| |#| ||+ | +||| || | | || +|+ Sbjct 469 ALMLLKSG#AGPNLTTDDGQTPVHVAASHGNLATLLLLL 506 |
| Hemicentrotus pulcherrimus | Query 29 PDALNRFGKTALQVMMFGSTAIALELL-KQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVL 87 |+ + |+| || +| + || + |#| ||+|| | + +| | ||+|| ++| Sbjct 499 PNVQDNAGRTPLQCAAYGGFIRCMTLLLEHG#ADPNLQDNEGMTALHWACSTGYLDATRLL 558 Query 88 V 88 + Sbjct 559 L 559 Query 46 GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | | + |+ # |||||| +| +|+ || ||+ + +|+ Sbjct 484 GHTCVCYHLMTHD#ISPNVQDNAGRTPLQCAAYGGFIRCMTLLL 526 |
| Rickettsiella grylli | Query 33 NRFGKTALQVMM-FGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 +|+|+| | | + || | + + |+++|#| | | | +|+| | | +++++++|+ Sbjct 652 DRYGRTPLHVAIWFGYTELVIYLVERG#ADVNSTDQLGNTPLHTAGITNYVNSIQILL 708 Query 30 DALNRFGKTAL-QVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 +| | | | | + | | |+ + #|+ + ||++|+|+||| | || +| |+ Sbjct 458 EANNDSGSTPLHEAARNGHLDIVKYLIGKN#ATIEANNDSGSTPLHEAARNGHLDIVKYLI 517 Query 33 NRFGKTALQVMMF-GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 |+ | | | | | + |+ + #|+ + ||++|+|+||| | || +| |+ Sbjct 428 NKMGVTPLYVASRNGHLDMVKYLIGKN#ATIEANNDSGSTPLHEAARNGHLDIVKYLI 484 |
| Wolbachia endosymbiont of Drosophila melanogaster | Query 30 DALNRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | ||+|+| | +| | + || + # + ||| | +|+|||| | ++ +| |+ Sbjct 140 DLKNRYGETPLHYAAKYGHTQVLENLLGRS#TNVNVQSEVGRTPLHDAANNGHIEVVKHLI 199 Query 46 GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | + |+|+|#| ||| | +|+|+||+ | ++||+ Sbjct 190 GHIEVVKHLIKKG#ADVNVQSKVGRTPLHNAAKHGHTQVVEVLL 232 Query 33 NRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 ++ |+| | | | + |||+|#| |+|| | +|+| | + + |+|+ Sbjct 209 SKVGRTPLHNAAKHGHTQVVEVLLKKG#ADVNIQDRGGRTPLHYAVQRRYPKLAKLLL 265 |
| Caenorhabditis briggsae | Query 30 DALNRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 +|+ +||| || |++ || |#|+|| +| | +|+| || | | +|+ + Sbjct 951 EAITLDNQTALHFAAKFGQLAVSQTLLALG#ANPNARDDKGQTPLHLAAENDFPDVVKLFL 1010 Query 31 ALNRFGKTALQVMMF-GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | | | | | + | |+ || ||+|# + + | +| || || | +|+|+ Sbjct 557 ARTRDGSTLLHIAACSGHTSTALAFLKRG#VPLMMPNKKGALGLHSAAAAGFNDVVKMLI 615 Query 30 DALNRFGKTALQVMMF-GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | + |+||| + | | +| ||+ #| | + +| +|+| ||+ | + + ||| Sbjct 884 DVFDEMGRTALHLAAFNGHLSIVHLLLQHK#AFVNSKSKTGEAPLHLAAQHGHVKVVNVLV 943 |
| Wolbachia pipientis | Query 30 DALNRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | ||+|+| | +| | + || + # + ||| | +|+|||| | ++ +| |+ Sbjct 139 DLKNRYGETPLHYAAKYGHTQVLENLLGRS#TNVNVQSEVGRTPLHDAANNGHIEVVKHLI 198 Query 46 GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | + |+|+|#| ||| | +|+|+|| |+++ +| |+ Sbjct 189 GHIEVVKHLIKKG#ADVNVQSKVGRTPLHNAANNGYIEVVKHLI 231 Query 33 NRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 ++ |+| | | | + |||+|#| |+|| | +|+| | + |+ |+|+ Sbjct 274 SKVGRTPLHNAAKHGHTQVVEVLLKKG#ADVNIQDRGGRTPLHYAVQRGYPKLAKLLL 330 Query 46 GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | + |+|+ #| || | | +|+||||+ | ++ +| |+ Sbjct 222 GYIEVVKHLIKKE#ADVNVVDQYGRTPLHDAAKHGRIEVVKHLI 264 Query 30 DALNRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 + ++++|+| | | + |+++ #| ||| | +|+|+||+ | ++||+ Sbjct 238 NVVDQYGRTPLHDAAKHGRIEVVKHLIEKE#ADVNVQSKVGRTPLHNAAKHGHTQVVEVLL 297 |
| Wolbachia endosymbiont of Drosophila willistoni TSC#14030-0811.24 | Query 30 DALNRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | ||+|+| | +| | + || + # + ||| | +|+|||| | ++ +| |+ Sbjct 140 DLKNRYGETPLHYAAKYGHTQVLENLLGRS#TNVNVQSEVGRTPLHDAANNGHIEVVKHLI 199 Query 46 GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | + |+|+|#| ||| | +|+|+|| |+++ +| |+ Sbjct 190 GHIEVVKHLIKKG#ADVNVQSKVGRTPLHNAANNGYIEVVKHLI 232 Query 33 NRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 ++ |+| | | | + |||+|#| |+|| | +|+| | + |+ |+|+ Sbjct 275 SKVGRTPLHNAAKHGHTQVVEVLLKKG#ADVNIQDRGGRTPLHYAVQRGYPKLAKLLL 331 Query 46 GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | + |+|+ #| || | | +|+||||+ | ++ +| |+ Sbjct 223 GYIEVVKHLIKKE#ADVNVVDQYGRTPLHDAAKHGRIEVVKHLI 265 Query 30 DALNRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 + ++++|+| | | + |+++ #| ||| | +|+|+||+ | ++||+ Sbjct 239 NVVDQYGRTPLHDAAKHGRIEVVKHLIEKE#ADVNVQSKVGRTPLHNAAKHGHTQVVEVLL 298 |
| Caenorhabditis elegans | Query 30 DALNRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 +|+ +||| || |++ || |#|+|| +| | +|+| || | | +|+ + Sbjct 934 EAITLDNQTALHFAAKFGQLAVSQTLLALG#ANPNARDDKGQTPLHLAAENDFPDVVKLFL 993 Query 31 ALNRFGKTALQVMMF-GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | | | | | + | |+ || ||+|# + + | +| || || | +|+|+ Sbjct 541 ARTRDGSTLLHIAACSGHTSTALAFLKRG#VPLFMPNKKGALGLHSAAAAGFNDVVKMLI 599 Query 30 DALNRFGKTALQVMMF-GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | + |+||| + | | ++ ||+ #| | + +| +|+| ||+ | + + ||| Sbjct 867 DVFDEMGRTALHLAAFNGHLSLVHLLLQHK#AFVNSKSKTGEAPLHLAAQHGHVKVVNVLV 926 Query 36 GKTALQVMMFGSTA----IALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 |+||| + + | |+ ||| |# |+| | + +| |||+| | +++|+ Sbjct 646 GQTALHIAASLNGAESRDCAMMLLKSG#GQPDVAQMDGETCLHIAARSGNKDIMRLLL 702 |
| Thermofilum pendens Hrk 5 | Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | |++ || | | + | + +| ||++|#| || +++|| +|+| || | ++ +++|+ Sbjct 245 PCAVDAFGNTPLH-LAFKNMEVAKLLLEKG#ADPNAKNSSGMTPLHFAAGLGKVEVVELLL 303 Query 32 LNRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | | |+| | ++| +| || +|#| || | | +|+| || || | ++|+ Sbjct 85 LGRKGRTPLHWAAVYGHFVVAEVLLDRG#ADPNATDEEGNTPLHLAALLGFADIARLLL 142 Query 29 PDALNRFGKTALQVM-MFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVL 87 |+| + | | | + + | || || +|#| | +++|| +|+| || | + |+| Sbjct 115 PNATDEEGNTPLHLAALLGFADIARLLLDRG#ADVNAKNSSGKTPLHYAAEQGSAEVAKLL 174 Query 88 V 88 + Sbjct 175 L 175 Query 30 DALNRFGKTALQVMMF-GSTAIALELLKQG#ASPNVQDTSGTSPVHDAART 78 +| | ||| | || +| ||++|#| | || | +|+| | |+ Sbjct 149 NAKNSSGKTPLHYAAEQGSAEVAKLLLERG#ADPGATDTYGNTPLHLAVRS 198 Query 29 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 | | + +| | | + + | ++ ||++|#| | ++ | +|+| || | + +| |+ Sbjct 181 PGATDTYGNTPLHLAV-RSIEVSKLLLERG#ADVNARNNEGRTPLHRAAMEGSAEVVKFLL 239 Query 30 DALNRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 88 +| + +|+| | | + ||+ |#| || ++ || +|+| || + |+|+ Sbjct 386 NAKDEYGRTPLHWAAERGCPEVVELLLEHG#ADPNARNDSGMTPLHLAATVKDTEAAKLLL 445 Query 29 PDALNRFGKTALQVMMFGSTAIALE-LLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVL 87 |+ + | | | + +| ||++|#| | ++ | +|+| || | + +|+| Sbjct 525 PNTRDNDGNTLLHAAAWNGDVEVIEILLERG#ADINARNKFGETPLHVAAERGNFEAVKLL 584 Query 88 V 88 + Sbjct 585 L 585 |
[Site 4] GHTAVVSFLA121-AESDLHRRDA
Ala121 Ala
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly112 | His113 | Thr114 | Ala115 | Val116 | Val117 | Ser118 | Phe119 | Leu120 | Ala121 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala122 | Glu123 | Ser124 | Asp125 | Leu126 | His127 | Arg128 | Arg129 | Asp130 | Ala131 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| ADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDI |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 120.00 | 33 | cyclin-dependent kinase inhibitor 2D |
| 2 | N/A | 120.00 | 17 | - |
| 3 | synthetic construct | 120.00 | 12 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 4 | Macaca mulatta | 118.00 | 16 | PREDICTED: cyclin-dependent kinase inhibitor 2D (p |
| 5 | Canis familiaris | 104.00 | 15 | PREDICTED: similar to Cyclin-dependent kinase 4 in |
| 6 | Bos taurus | 102.00 | 3 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 7 | Mus musculus | 95.10 | 18 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 8 | Rattus norvegicus | 94.00 | 6 | similar to cyclin-dependent kinase inhibitor 2D |
| 9 | Monodelphis domestica | 90.10 | 6 | PREDICTED: similar to Cyclin-dependent kinase inhi |
| 10 | Xenopus tropicalis | 59.70 | 1 | cyclin-dependent kinase inhibitor 2D (p19, inhibit |
| 11 | Takifugu rubripes | 59.30 | 1 | p19 |
| 12 | Xenopus laevis | 58.50 | 2 | ankyrin 2, neuronal |
| 13 | Xiphophorus maculatus | 57.40 | 1 | p19 |
| 14 | Tribolium castaneum | 50.10 | 3 | PREDICTED: similar to CG6742-PA, isoform A |
| 15 | Anopheles gambiae str. PEST | 49.30 | 1 | ENSANGP00000001193 |
| 16 | Drosophila melanogaster | 48.90 | 2 | TRPA1_DROME Transient receptor potential cation ch |
| 17 | Drosophila pseudoobscura | 48.90 | 1 | GA19105-PA |
| 18 | Tetraodon nigroviridis | 48.10 | 4 | unnamed protein product |
| 19 | Aedes aegypti | 48.10 | 1 | conserved hypothetical protein |
| 20 | Strongylocentrotus purpuratus | 47.80 | 62 | PREDICTED: similar to putative transient receptor |
| 21 | Aspergillus clavatus NRRL 1 | 47.40 | 2 | Ankyrin repeat protein |
| 22 | Gallus gallus | 47.00 | 3 | PREDICTED: similar to Chain A, Crystal Structure O |
| 23 | Arabidopsis thaliana | 46.20 | 3 | putative potassium transporter/channel |
| 24 | Danio rerio | 45.40 | 6 | PREDICTED: hypothetical protein |
| 25 | Egeria densa | 45.10 | 1 | inward potassium channel alpha subunit |
| 26 | Neosartorya fischeri NRRL 181 | 45.10 | 1 | Ankyrin repeat protein |
| 27 | Pan troglodytes | 44.70 | 6 | PREDICTED: huntingtin interacting protein 14 |
| 28 | Macaca fascicularis | 44.70 | 1 | unnamed protein product |
| 29 | Wolbachia endosymbiont of Drosophila melanogaster | 43.90 | 3 | ankyrin repeat domain protein |
| 30 | Trichomonas vaginalis G3 | 40.80 | 5 | ankyrin repeat protein, putative |
| 31 | Cyanothece sp. CCY0110 | 38.90 | 1 | Ankyrin |
| 32 | Apis mellifera | 36.20 | 1 | PREDICTED: similar to Ankyrin repeat and FYVE doma |
| 33 | Aspergillus niger | 35.00 | 1 | hypothetical protein An12g05680 |
| 34 | Wolbachia pipientis | 34.30 | 2 | ankyrin domain protein |
| 35 | Wolbachia endosymbiont of Drosophila willistoni TSC#14030-0811.24 | 34.30 | 2 | hypothetical protein Wendoof_01000289 |
| 36 | Wolbachia endosymbiont of Drosophila simulans | 34.30 | 1 | ankyrin repeat domain protein |
| 37 | Caenorhabditis elegans | 34.30 | 1 | TRP (transient receptor potential) channel family |
| 38 | Aspergillus nidulans FGSC A4 | 32.70 | 1 | hypothetical protein AN8767.2 |
| 39 | Legionella pneumophila str. Lens | 32.70 | 1 | hypothetical protein lpl2058 |
| 40 | Caenorhabditis briggsae | 32.70 | 1 | Hypothetical protein CBG13617 |
| 41 | Magnaporthe grisea 70-15 | 32.30 | 1 | hypothetical protein MGG_05629 |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 |
| N/A | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 |
| synthetic construct | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 |
| Macaca mulatta | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 |||| |||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 98 ADVNAPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 |
| Canis familiaris | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 |||| |||||||||||||+|||||||||||# ||||| |||||||||||| |||||+|| Sbjct 98 ADVNAPDGTGALPIHLAVREGHTAVVSFLA#TESDLHHRDARGLTPLELAQGIGAQDLMDI 157 |
| Bos taurus | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 |||| |||||||||||||+||||+||||||# ||||| ||| |||||||| ||||+|+|| Sbjct 98 ADVNAPDGTGALPIHLAVREGHTSVVSFLA#TESDLHHRDATGLTPLELARGRGAQELMDI 157 |
| Mus musculus | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 |||| | ||+||||||++|||++||||||# ||||| ||| |||||||| |||||+|+|| Sbjct 98 ADVNALDSTGSLPIHLAIREGHSSVVSFLA#PESDLHHRDASGLTPLELARQRGAQNLMDI 157 |
| Rattus norvegicus | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 |||| | ||+||||||++|||++||||||# ||||| +|| |||||||| |||||+|+|| Sbjct 98 ADVNTLDSTGSLPIHLAIREGHSSVVSFLA#PESDLHHKDASGLTPLELARQRGAQNLMDI 157 |
| Monodelphis domestica | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDL 148 ||||||||+|||||||||+||| |||||||# |||| ||| |||||||| | || | Sbjct 98 ADVNVPDGSGALPIHLAVREGHAAVVSFLA#GESDLQHRDAGGLTPLELARQCGAGQL 154 |
| Xenopus tropicalis | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELA 140 |++| || +|+||||||++ || |+++||# ||| || | || +|| Sbjct 98 AEINTPDASGSLPIHLALKAGHVPVITYLA#LISDLQHRDREGHTPSQLA 146 |
| Takifugu rubripes | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 | ||+|| +||||||+|++||| || |||# ||| + | | ++| |++|+ Sbjct 98 ASVNLPDQSGALPIHIAIREGHRDVVEFLA#PRSDLKHANKSGQTAADVARASRVPDMMDL 157 |
| Xenopus laevis | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELA 140 |+|| || +|+||||||++ || |+++||# ||| + | | || +|| Sbjct 98 AEVNTPDASGSLPIHLALKAGHVPVITYLA#LISDLQQHDREGHTPSQLA 146 |
| Xiphophorus maculatus | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVD 150 | ||+ | ||||||+|++||| +| |||# ||| + | | +++| | |+++ Sbjct 98 ASVNIQDQNGALPIHIAIREGHRDIVEFLA#PRSDLKHANVSGQTAIDVARSLGELDMMN 156 |
| Tribolium castaneum | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#A-ESDLHRRDARGLTPLELALQRGAQDLVD 150 | +| | | |+||| |||||| | | # +| | | | ||++| |+ |+| Sbjct 679 AKINAQDQNGKTPLHLATQEGHTAQVCLLL#KHRADQHLEDDEGKVPLQMAEQKEHADIVT 738 Query 151 I 151 + Sbjct 739 L 739 |
| Anopheles gambiae str. PEST | Query 94 VNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 +| || | |+|+| |+||| || | # | || | || || | + +++ Sbjct 490 INESDGEGLTPLHIASQQGHTRVVQLLL#NRGALLHRDHNGRNPLHLAAMSGYRQTIEL 547 |
| Drosophila melanogaster | Query 94 VNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 +| || | |+|++ |+||| || | # | || | ||+|| | + +++ Sbjct 506 INESDGAGMTPLHISSQQGHTRVVQLLL#NRGALLHRDHTGRNPLQLAAMSGYTETIEL 563 |
| Drosophila pseudoobscura | Query 94 VNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 +| || | |+|++ |+||| || | # | || | ||+|| | + +++ Sbjct 519 INESDGAGMTPLHISSQQGHTRVVQLLL#NRGALLHRDHTGRNPLQLAAMSGYTETIEL 576 |
| Tetraodon nigroviridis | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 || | | || ||+|+| | |+ +|| | #| + | |++|| +| + |++++ Sbjct 231 ADANKPGKTGLLPLHVAAQTGNDTIVSMLI#AVTSKARVRRTGISPLHVAAEHNCDDVLEL 290 |
| Aedes aegypti | Query 94 VNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 +| || | |+|+| +|||| || | # | || | || || | +++ Sbjct 197 INESDGEGLTPLHIASKEGHTRVVQLLL#NRGALLHRDHNGRNPLHLAAMSGYTQTIEL 254 |
| Strongylocentrotus purpuratus | Query 101 GALPIHLAVQEGHTAVVSFLA#AES--DLHRRDARGLTPLELALQRGAQDLV 149 | +|+||| | |||||| | #++| || +| || | | | | |+| Sbjct 1 GTIPLHLAAQNGHTAVVGLLL#SKSTTQLHVKDKRGRTGLHQAAANGHYDMV 51 |
| Aspergillus clavatus NRRL 1 | Query 92 ADVNVPDGTGALPIHLAVQEG----HTAVVSFLA-#AESDLHRRDARGLTPLELALQRGAQ 146 ||||| || | |+|+ | | ||| | #+ + | +| ||||||++| + | Sbjct 208 ADVNVVDGNGRTPLHVCAATGNTADHVAVVRLLVN#SGASLSTKDHRGLTPLQVAAEAGNH 267 Query 147 DLVD 150 +++ Sbjct 268 RIIE 271 |
| Gallus gallus | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFL--A#AESDLHRRDARGLTPLELA 140 ||||+ | | ||+||| |||| || || # | + ++ || | |++| Sbjct 94 ADVNIEDAEGNLPLHLAAQEGHVRVVEFLLRR#TPSRVAHQNRRGDTALDVA 144 |
| Arabidopsis thaliana | Query 93 DVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDL 148 || +||| | +| || ||| +| || # + +|| |+ | || || +| +++ Sbjct 253 DVTLPDGNGTTALHRAVSEGHLEIVKFLL#DQGADLDWPDSYGWTPRGLADHQGNEEI 309 |
| Danio rerio | Query 101 GALPIHLAVQEGHTAVVSFLA--#AESDLHRRDARGLTPLELALQRGAQDLV 149 || |++|| |||| || || # ++|+| | |+||| | | || Sbjct 2 GATPLYLACQEGHLHVVEFLVKD#CQADVHLRAQDGMTPLHAAAHMGHHSLV 52 |
| Egeria densa | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDL 148 ||+|+| +|+ +| || +|+ +|||| # +| | | | || | | |+| |+ Sbjct 544 ADINLPKRSGSTALHSAVCDGNVEIVSFLL#QHGADPDRPDINGWTPREYADQQGHHDI 601 |
| Neosartorya fischeri NRRL 181 | Query 93 DVNVPDGTGALPIHLAVQEGHTAVVSFLA#AES--DLHRRDARGLTPL 137 +|| | | |+| ||++|| |||+ #|+ |++| |+|| ||+ Sbjct 215 EVNTRDNRGRTPLHRAVEKGHLAVVNLFL#AQPNIDINRADSRGRTPM 261 |
| Pan troglodytes | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQR 143 || ++ || | |||| | |||++|++| #|+ |+ | |+||| | | Sbjct 279 ADPSLIDGEGCSCIHLAAQFGHTSIVAYLI#AKGQDVDMMDQNGMTPLMWAAYR 331 |
| Macaca fascicularis | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQR 143 || ++ || | |||| | |||++|++| #|+ |+ | |+||| | | Sbjct 10 ADPSLIDGEGCSCIHLAAQFGHTSIVAYLI#AKGQDVDMMDQNGMTPLMWAAYR 62 |
| Wolbachia endosymbiont of Drosophila melanogaster | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVD 150 || || | |+| |+ || | # + ++ +| | ||| || + +|+| Sbjct 48 ADFNVVDNENRNPLHYAIMHGHKKVAKLFV#NQLTINSKDKNGFTPLHLAALQDDTELID 106 |
| Trichomonas vaginalis G3 | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFL-A#AESDLHRRDARGLTPLELALQRGAQDLVD 150 || | | || |++ | || ||| +| +# +| + ++ ||++|| +| || |+|| Sbjct 76 ADKEVKDDIGATPLYWASNNGHLAVVKYLIS#MGADKNIKNNRGISPLFIASVRGRYDVVD 135 Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFL-A#AESDLHRRDARGLTPLELALQRGAQDLVD 150 |||| |+ | +|+ | ||| || +| +# |+|+ +| | | |++| + ++| Sbjct 142 ADVNEPNCDGWIPLFAAAYEGHLRVVEYLIS#VRSNLNHKDNSGRTFLDIANNKIQGTIID 201 Query 151 I 151 + Sbjct 202 L 202 |
| Cyanothece sp. CCY0110 | Query 93 DVNVPDGTGALPIHLAVQEGHTAVV-SFLA#AESDLHRRDARGLTPLELALQRGAQDLV 149 |+|+|| | + || || ||++ + ||#| +++|| | ||| | | + | Sbjct 191 DINIPDNEGETLLSLAASEGQTAIIQALLA#AGEAVNQRDEEGETPLHYATVEGHLEAV 248 Query 94 VNVPDGTGALPIHLAVQEGH-TAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLV 149 || | | |+| | ||| || + ||# +++| + | ||| ||+ +| ++| Sbjct 225 VNQRDEEGETPLHYATVEGHLEAVRALLA#GGANVHLANQFGDTPLILAVVQGHSEIV 281 |
| Apis mellifera | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA--#AESDLHRRDARGLTPLELAL 141 |||| | | |||+|+| |+ ++| | # ||+ || +|||| || Sbjct 705 ADVNARDIEGKTPIHVAIQNQHSQIISLLLYH#PNIDLNIRDKKGLTPFATAL 756 Query 97 PDGTGA-------LPIHLAVQEGHTAVVSFLA#A-ESDLHRRDARGLTPLELALQRGAQDL 148 ||||| |+|| | | |+ | # ++|++ || | ||+ +|+| + Sbjct 670 PDGTGGDEARDECTPLHLCCQWGLEQVIQTLI#EHDADVNARDIEGKTPIHVAIQNQHSQI 729 Query 149 VDI 151 + + Sbjct 730 ISL 732 |
| Aspergillus niger | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#A--ESDLHRRDARGLTPLELALQRGAQDLV 149 ||++ | +| |+ || | || ||| + #| | |++ +|+|| ||+ | + | + +| Sbjct 943 ADIDSRDSSGNSPLSLAAQFGHEAVVKIVL#ATGEVDVNNKDSRGKTPISWAAREGYEAVV 1002 Query 93 DVNVPDGTGALPIHLAVQEGHTAVVSFLA#A--ESDLHRRDARGLTPLELALQRGAQDLVD 150 |++ | |+ |+ || + || +| | #| ++|+ ||+ | +|| || | | + +| Sbjct 910 DIDSKDVPGSTPLALAAENGHERIVRLLL#ATGKADIDSRDSSGNSPLSLAAQFGHEAVVK 969 Query 151 I 151 | Query 151 I 151 Query 104 PIHLAVQEGHTAVVSFLA#A--ESDLHRRDARGLTPLELALQRGAQDLVDI 151 |+ | + || ||| | #| | |+ |++ | +|| || | | ++| + Sbjct 854 PLSWAAERGHVAVVKLLL#AAEEVDIDSRNSIGRSPLSLAAQNGHDEVVKL 903 Query 93 DVNVPDGT-GALPIHLAVQEGHTAVVSFLA#A--ESDLHRRDAR-GLTPLELALQRGAQDL 148 |||+ | | |+ | ||| ||| | #+ | |+ || | | +|| | | +++ Sbjct 1046 DVNIRDRRYGREPLSWAAGEGHEAVVKLLL#STREVDVDVRDPRYGRSPLSWAAGEGHEEV 1105 Query 149 VDI 151 |++ Sbjct 1106 VEL 1108 Query 93 DVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDL--HRRDARGLTPLELALQRGAQDLVD 150 || | |+ | ||| || | #| ++ + ||+ | ||| | + | + ++ Sbjct 1116 DVESKSIRGRTPLSWAAWEGHDIVVKLLL#ATGEVVVNSRDSEGRTPLSWAAENGNEAVIK 1175 Query 151 I 151 + Sbjct 1176 L 1176 |
| Wolbachia pipientis | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVD 150 || || | |+| |+ || | # + ++ +| | ||| || + +|+| Sbjct 30 ADFNVVDNENRNPLHYAIMHGHKKVAKLFV#NQLTINSKDKNGFTPLHLAALQDDTELID 88 Query 93 DVNVPDGTGALPIHLAVQEGHTAVVS-FLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 +|| |+ |||++||| +| | # ++++ + +| || ||+|+ |+ + Sbjct 278 NVNAVTKCNRTPLLLAVKKGHTQIVKMLLE#VRANMNICEQQGFAPLHLAVQKDYFDIAQL 337 |
| Wolbachia endosymbiont of Drosophila willistoni TSC#14030-0811.24 | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVD 150 || || | |+| |+ || | # + ++ +| | ||| || + +|+| Sbjct 48 ADFNVVDNENRNPLHYAIMHGHKKVAKLFV#NQLTINSKDKNGFTPLHLAALQDDTELID 106 Query 93 DVNVPDGTGALPIHLAVQEGHTAVVS-FLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 +|| |+ |||++||| +| | # ++++ + +| || ||+|+ |+ + Sbjct 296 NVNAVTKCNRTPLLLAVKKGHTQIVKMLLE#VRANMNICEQQGFAPLHLAVQKDYFDIAQL 355 |
| Wolbachia endosymbiont of Drosophila simulans | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVD 150 || || | |+| |+ || | # + ++ +| | ||| || + +|+| Sbjct 48 ADFNVVDNENRNPLHYAIMHGHKKVAKLFV#NQLTINSKDKNGFTPLHLAALQDDTELID 106 Query 93 DVNVPDGTGALPIHLAVQEGHTAVVS-FLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 151 +|| |+ |||++||| +| | # ++++ + +| || ||+|+ |+ + Sbjct 296 NVNAVTKCNRTPLLLAVKKGHTQIVKMLLE#VRANMNICEQQGFAPLHLAVQKDYFDIAQL 355 |
| Caenorhabditis elegans | Query 103 LPIHLAVQEGHTAVVSFLA#AES--DLHRRDARGLTPLELALQRGAQDLVDI 151 +|+||| |+|| ||| | #+ | | +| || ||| || | | ++| + Sbjct 1194 IPLHLAAQQGHIAVVGMLL#SRSTQQQHAKDWRGRTPLHLAAQNGHYEMVSL 1244 Query 98 DGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDLVDI 151 | | |+||| | || +|| | #|+ |+++ | | | | | + | +| + Sbjct 1223 DWRGRTPLHLAAQNGHYEMVSLLI#AQGSNINVMDQNGWTGLHFATRAGHLSVVKL 1277 Query 98 DGTGALPIHLAVQEGHTAVVSFL---A#AESDLHRRDARGLTPLELALQRG 144 || |+|||||| + |+ +| | #++ + | | | | || + | Sbjct 407 DGDGSLPIHLAFKFGNVNIVELLLSGP#SDEQTRKADGNGDTLLHLAARSG 456 |
| Aspergillus nidulans FGSC A4 | Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDLVD 150 ||||+|| | |+ ||+ || ||| | # |+ + | | ||| |+ +| |++| Sbjct 106 ADVNIPDSKGQTPLSWAVENGHQAVVQLLL#GHGSNPNTPDPGGQTPLSCAVSKGNQEIVK 165 Query 151 I 151 + Sbjct 166 L 166 Query 95 NVPDGTGALPIHLAVQEGHTAVVSFLA#AESDL--HRRDARGLTPLELALQRGAQDLVDI 151 | || | |+ || +|+ +| | #+ ||| + ||||| |+ | +++| + Sbjct 142 NTPDPGGQTPLSCAVSKGNQEIVKLLL#SSSDLECNTPHPNGLTPLCWAVNEGQEEIVQL 200 Query 93 DVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDL--HRRDARGLTPLELALQRGAQDLV 149 + | | | |+ || || +| | # ||+ ++ | | || |+++ + +| Sbjct 174 ECNTPHPNGLTPLCWAVNEGQEEIVQLLL#DRSDVDPNKPDTDGYAPLSRAVEKNSLAMV 232 |
| Legionella pneumophila str. Lens | Query 93 DVNVPDGTGALPIHLAVQEGHTAVVSFLA#A-ESDLHRRDARGLTPLELALQRGAQDLVD 150 | | | |+ | ||| + || ||++ ||# ++||++ | | || +| | ++| Sbjct 460 DFNKKDINGSTPAHLAARNGHVAVIAELA#KHQADLNKADNDGFTPAHIAALTGQSMVLD 518 Query 93 DVNVPDGTGALPIHLAVQEGHTAVVSFLA#AES-DLHRRDARGLTPLELALQRG 144 | | + | | ||| + || ||++ ||# + ++ + | || || | | Sbjct 361 DFNKTNERGDTPAHLAARNGHVAVIAELA#KHGVNFNKANRSGDTPAHLAAQNG 413 Query 95 NVPDGTGALPIHLAVQEGHTAVVSFLA#AES-DLHRRDARGLTPLELALQRG 144 | +| | ||| | || | + ||# | ++ + || || || + | Sbjct 330 NKTSRSGNTPAHLAAQNGHVAAIIELA#KYGVDFNKTNERGDTPAHLAARNG 380 Query 95 NVPDGTGALPIHLAVQEGHTAVVSFLA#AES-DLHRRDARGLTPLELALQRG 144 | + +| | ||| | || ||++ ||# + ++|+++ | | +| | Sbjct 396 NKANRSGDTPAHLAAQNGHAAVITELA#KNNVNVHQQNEHGSTLAHIAALNG 446 Query 93 DVNVPDGTGALPIHLAVQEGHTAVVSFLA#A-ESDLHRRDARGLTPLELALQRG 144 |+| | | | |||| | +| ||# + | ++ |+| || |+| Sbjct 262 DLNKADKDGFTPAHLAVLHGDVTFISELA#RHQVDFNKVTKHGVTTAHLAAQQG 314 Query 101 GALPIHLAVQEGHTAVVSFLA#A-ESDLHRRDARGLTPLELALQRG 144 |+ |+| || |++ ||# + | +++| | || || + | Sbjct 435 GSTLAHIAALNGHAVVIAELA#KHQVDFNKKDINGSTPAHLAARNG 479 |
| Caenorhabditis briggsae | Query 103 LPIHLAVQEGHTAVVSFLA#AES--DLHRRDARGLTPLELALQRGAQDLVDI 151 +|+||| |+|| ||| | #+ | | +| || ||| || | | ++| + Sbjct 1211 IPLHLAAQQGHIAVVGMLL#SRSTQQQHAKDWRGRTPLHLAAQNGHYEMVSL 1261 Query 98 DGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDLVDI 151 | | |+||| | || +|| | #|+ |+++ | | | | | + | +| + Sbjct 1240 DWRGRTPLHLAAQNGHYEMVSLLI#AQGSNINVMDQNGWTGLHFATRAGHLSVVKL 1294 Query 98 DGTGALPIHLAVQEGHTAVVSFL---A#AESDLHRRDARGLTPLELALQRGAQDLV 149 || |+|||||| + |+ +| | #++ + | | | | || + |+ + | Sbjct 423 DGEGSLPIHLAFKFGNVNIVELLLSGP#SDEQTRKADGNGDTLLHLAARSGSIEAV 477 Query 92 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#A-ESDLHRRDARGLTPLELALQRGAQDLVD 150 | ++| | | +||| || ++| | # ++ ++ + | || || | | +|+ Sbjct 881 ARIDVFDEMGRTALHLAAFNGHLSIVHLLL#QHKAFVNSKSKTGEAPLHLAAQHGHVKVVN 940 Query 151 I 151 + Sbjct 941 V 941 |
| Magnaporthe grisea 70-15 | Query 93 DVNVPDGTGALPIHLAVQEGHTAVVSFLA#AES--DLHRRDARGLTPLELALQRGAQDLVD 150 |+| | | |+||| | | || | #++| |++ || +| ||| | +| | |+ Sbjct 1458 DLNARDEDGRTPLHLAAANGETRVVKMLL#SQSGVDINARDDQGQTPLHRAAAQGYHDFVE 1517 Query 93 DVNVPDGTGALPIHLAVQEGH---------------TAVVSFLA#AES--DLHRRDARGLT 135 |+| | | |+| | +|+ |+ + | #|+ +++ || ||| Sbjct 1492 DINARDDQGQTPLHRAAAQGYHDFVEAYSIKDYSDRTSALRLLL#ADDRIEVNARDKDGLT 1551 Query 136 PLELALQRGAQDLVDI 151 ||+ |+ | | + Sbjct 1552 PLQQAVAFGQPQSVQV 1567 |
* References
[PubMed ID: 9437433] Venkataramani R, Swaminathan K, Marmorstein R, Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations. Nat Struct Biol. 1998 Jan;5(1):74-81.
[PubMed ID: 9782052] ... Baumgartner R, Fernandez-Catalan C, Winoto A, Huber R, Engh RA, Holak TA, Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a. Structure. 1998 Oct 15;6(10):1279-90.