logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2216 : integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) [Equus caballus]

[ CaMP Format ]

This entry is computationally expanded from SB0043

* Basic Information

OrganismEquus caballus (horse)
Protein NamesIntegrin beta; integrin; beta 3 (platelet glycoprotein IIIa; antigen CD61); platelet glycoprotein IIIa integrin subunit beta 3
Gene NamesITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Gene Locus11; chromosome 11
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001075271 NM_001081802 100009709 Q52MQ6_HORSE N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 784 aa

Average Mass: 86.360 kDa

Monoisotopic Mass: 86.303 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 344571008.82.1e-300
EGF_2 1. 45949312.90.097
EGF_2 2. 50854330.28.1e-06
EGF_2 3. 55058022.80.0014
EGF_2 4. 58962030.28.2e-06
Integrin_B_tail 1. 630714127.06.2e-35
Integrin_b_cyt 1. 738783106.87.1e-29
--- cleavage 763 (inside Integrin_b_cyt 738..783) ---
--- cleavage 781 (inside Integrin_b_cyt 738..783) ---
--- cleavage 769 (inside Integrin_b_cyt 738..783) ---
--- cleavage 757 (inside Integrin_b_cyt 738..783) ---

3. Sequence Information

Fasta Sequence: XSB2216.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites]

Cleavage sites (±10aa)

[Site 1] EERARAKWDT763-ANNPLYKEAT

Thr763 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu754Glu755Arg756Ala757Arg758Ala759Lys760Trp761Asp762Thr763
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala764Asn765Asn766Pro767Leu768Tyr769Lys770Glu771Ala772Thr773

Sequence conservation (by blast)

[Site 2] ATSTFTNITY781-RGT

Tyr781 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala772Thr773Ser774Thr775Phe776Thr777Asn778Ile779Thr780Tyr781
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Arg782Gly783Thr784-------

Sequence conservation (by blast)

[Site 3] KWDTANNPLY769-KEATSTFTNI

Tyr769 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys760Trp761Asp762Thr763Ala764Asn765Asn766Pro767Leu768Tyr769
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys770Glu771Ala772Thr773Ser774Thr775Phe776Thr777Asn778Ile779

Sequence conservation (by blast)

[Site 4] EFAKFEEERA757-RAKWDTANNP

Ala757 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu748Phe749Ala750Lys751Phe752Glu753Glu754Glu755Arg756Ala757
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Arg758Ala759Lys760Trp761Asp762Thr763Ala764Asn765Asn766Pro767

Sequence conservation (by blast)

* References

[PubMed ID: 16407493] Christopherson PW, Insalaco TA, van Santen VL, Livesey L, Bourne C, Boudreaux MK, Characterization of the cDNA Encoding alphaIIb and beta3 in normal horses and two horses with Glanzmann thrombasthenia. Vet Pathol. 2006 Jan;43(1):78-82.