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XSB2217 : integrin beta 3 precursor [Mus musculus]

[ CaMP Format ]

This entry is computationally expanded from SB0043

* Basic Information

OrganismMus musculus (house mouse)
Protein NamesIntegrin beta; integrin beta 3 precursor; platelet gpIIIa
Gene NamesItgb3; RP24-460H24.1-001, mCG_11220; integrin beta 3
Gene Locus11 68.0 cM; chromosome 11
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_058060 NM_016780 16416 Q3TZC6_MOUSE N/A N/A N/A mmu:16416

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 787 aa

Average Mass: 86.738 kDa

Monoisotopic Mass: 86.681 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 374601009.11.7e-300
EGF_2 1. 46249618.50.022
EGF_2 2. 51154631.92.6e-06
EGF_2 3. 55358326.50.00011
EGF_2 4. 59262323.80.00071
Integrin_B_tail 1. 633717128.12.8e-35
Integrin_b_cyt 1. 741786106.87.1e-29
--- cleavage 766 (inside Integrin_b_cyt 741..786) ---
--- cleavage 784 (inside Integrin_b_cyt 741..786) ---
--- cleavage 772 (inside Integrin_b_cyt 741..786) ---
--- cleavage 760 (inside Integrin_b_cyt 741..786) ---

3. Sequence Information

Fasta Sequence: XSB2217.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites]

Cleavage sites (±10aa)

[Site 1] EERARAKWDT766-ANNPLYKEAT

Thr766 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu757Glu758Arg759Ala760Arg761Ala762Lys763Trp764Asp765Thr766
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala767Asn768Asn769Pro770Leu771Tyr772Lys773Glu774Ala775Thr776

Sequence conservation (by blast)

[Site 2] ATSTFTNITY784-RGT

Tyr784 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala775Thr776Ser777Thr778Phe779Thr780Asn781Ile782Thr783Tyr784
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Arg785Gly786Thr787-------

Sequence conservation (by blast)

[Site 3] KWDTANNPLY772-KEATSTFTNI

Tyr772 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys763Trp764Asp765Thr766Ala767Asn768Asn769Pro770Leu771Tyr772
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys773Glu774Ala775Thr776Ser777Thr778Phe779Thr780Asn781Ile782

Sequence conservation (by blast)

[Site 4] EFAKFEEERA760-RAKWDTANNP

Ala760 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu751Phe752Ala753Lys754Phe755Glu756Glu757Glu758Arg759Ala760
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Arg761Ala762Lys763Trp764Asp765Thr766Ala767Asn768Asn769Pro770

Sequence conservation (by blast)

* References

[PubMed ID: 19255147] Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC, Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor. J Exp Med. 2009 Mar 16;206(3):691-705. Epub 2009 Mar 2.

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