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XSB2219 : integrin, beta 3 precursor [Gallus gallus]

[ CaMP Format ]

This entry is computationally expanded from SB0043

* Basic Information

OrganismGallus gallus (chicken)
Protein NamesIntegrin beta; integrin; beta 3 precursor
Gene NamesITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Gene Locus27; chromosome 27
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_989646 NM_204315 374209 Q92071_CHICK N/A N/A N/A gga:374209

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 781 aa

Average Mass: 86.116 kDa

Monoisotopic Mass: 86.059 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 31453956.89.9e-285
EGF_2 1. 45548913.30.087
EGF_2 2. 50453930.09.4e-06
EGF_2 3. 54657627.74.7e-05
EGF_2 4. 58561632.51.7e-06
Integrin_B_tail 1. 626710128.22.7e-35
Integrin_b_cyt 1. 734779107.64.2e-29
--- cleavage 759 (inside Integrin_b_cyt 734..779) ---
--- cleavage 777 (inside Integrin_b_cyt 734..779) ---
--- cleavage 765 (inside Integrin_b_cyt 734..779) ---
--- cleavage 753 (inside Integrin_b_cyt 734..779) ---

3. Sequence Information

Fasta Sequence: XSB2219.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites]

Cleavage sites (±10aa)

[Site 1] EEKARAKWDT759-GNNPLYKEAT

Thr759 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu750Glu751Lys752Ala753Arg754Ala755Lys756Trp757Asp758Thr759
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gly760Asn761Asn762Pro763Leu764Tyr765Lys766Glu767Ala768Thr769

Sequence conservation (by blast)

[Site 2] ATSTFTNITY777-RGNM

Tyr777 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala768Thr769Ser770Thr771Phe772Thr773Asn774Ile775Thr776Tyr777
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Arg778Gly779Asn780Met781------

Sequence conservation (by blast)

[Site 3] KWDTGNNPLY765-KEATSTFTNI

Tyr765 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys756Trp757Asp758Thr759Gly760Asn761Asn762Pro763Leu764Tyr765
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys766Glu767Ala768Thr769Ser770Thr771Phe772Thr773Asn774Ile775

Sequence conservation (by blast)

[Site 4] EFARFEEEKA753-RAKWDTGNNP

Ala753 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu744Phe745Ala746Arg747Phe748Glu749Glu750Glu751Lys752Ala753
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Arg754Ala755Lys756Trp757Asp758Thr759Gly760Asn761Asn762Pro763

Sequence conservation (by blast)

* References

[PubMed ID: 8119143] Mimura H, Cao X, Ross FP, Chiba M, Teitelbaum SL, 1,25-Dihydroxyvitamin D3 transcriptionally activates the beta 3-integrin subunit gene in avian osteoclast precursors. Endocrinology. 1994 Mar;134(3):1061-6.

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