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XSB2220 : Itgb3 protein [Xenopus laevis]

[ CaMP Format ]

This entry is computationally expanded from SB0043

* Basic Information

OrganismXenopus laevis (African clawed frog)
Protein NamesIntegrin beta; itgb3 protein
Gene Namesitgb3
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAI69991 N/A 397699 B7ZQZ8_XENLA N/A N/A N/A xla:397699

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 788 aa

Average Mass: 87.467 kDa

Monoisotopic Mass: 87.410 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin_beta 1. 35459922.52.1e-274
EGF_2 1. 46149525.40.00024
EGF_2 2. 51054523.70.00077
EGF_2 3. 55258230.85.4e-06
EGF_2 4. 59162232.22.1e-06
Integrin_B_tail 1. 632716123.66.4e-34
Integrin_b_cyt 1. 740785110.26.9e-30
--- cleavage 765 (inside Integrin_b_cyt 740..785) ---
--- cleavage 783 (inside Integrin_b_cyt 740..785) ---
--- cleavage 771 (inside Integrin_b_cyt 740..785) ---
--- cleavage 759 (inside Integrin_b_cyt 740..785) ---

3. Sequence Information

Fasta Sequence: XSB2220.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites]

Cleavage sites (±10aa)

[Site 1] EERAKAKWDT765-AHNPLYKGAT

Thr765 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu756Glu757Arg758Ala759Lys760Ala761Lys762Trp763Asp764Thr765
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala766His767Asn768Pro769Leu770Tyr771Lys772Gly773Ala774Thr775

Sequence conservation (by blast)

[Site 2] ATSTFTNITY783-RGNTE

Tyr783 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala774Thr775Ser776Thr777Phe778Thr779Asn780Ile781Thr782Tyr783
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Arg784Gly785Asn786Thr787Glu788-----

Sequence conservation (by blast)

[Site 3] KWDTAHNPLY771-KGATSTFTNI

Tyr771 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys762Trp763Asp764Thr765Ala766His767Asn768Pro769Leu770Tyr771
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys772Gly773Ala774Thr775Ser776Thr777Phe778Thr779Asn780Ile781

Sequence conservation (by blast)

[Site 4] EFAKFEEERA759-KAKWDTAHNP

Ala759 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu750Phe751Ala752Lys753Phe754Glu755Glu756Glu757Arg758Ala759
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys760Ala761Lys762Trp763Asp764Thr765Ala766His767Asn768Pro769

Sequence conservation (by blast)

* References

[PubMed ID: 12454917] Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW, Richardson P, Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Dev Dyn. 2002 Dec;225(4):384-91.

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