CaMPDB :: Substrate

XSB2225 : growth associated protein 43 [Mus musculus]

This entry is computationally expanded from SB0067

* Basic Information

Organism	Mus musculus (house mouse)
Protein Names	Neuromodulin; Axonal membrane protein GAP-43; Growth-associated protein 43; Calmodulin-binding protein P-57; growth associated protein 43; growth accentuating protein 43; brain abundant; membrane attached signal protein 2
Gene Names	Gap43; Basp2; growth associated protein 43
Gene Locus	16 29.5 cM; chromosome 16
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_032109	NM_008083	14432	NEUM_MOUSE	N/A	N/A	N/A	mmu:14432

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 227 aa

Average Mass: 23.632 kDa

Monoisotopic Mass: 23.618 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Neuromodulin_N 1.	1	31	64.2	4.7e-16
--- cleavage 4 (inside Neuromodulin_N 1..31) ---
IQ 1.	32	52	32.4	1.9e-06
Neuromodulin 1.	67	227	246.0	9.4e-71

3. Sequence Information

Fasta Sequence: XSB2225.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] MLCC⁴-MRRTKQVEKN

Cys⁴ Met

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

-	-	-	-	-	-	Met¹	Leu²	Cys³	Cys⁴

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Met⁵	Arg⁶	Arg⁷	Thr⁸	Lys⁹	Gln¹⁰	Val¹¹	Glu¹²	Lys¹³	Asn¹⁴

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
MLCCMRRTKQVEKNDEDQKIEQDGVKPEDKAHKA

Summary

#	organism	max score	hits	top seq
1	Rattus norvegicus	75.10	1	growth associated protein 43
2	Mus musculus	75.10	1	growth associated protein 43
3	N/A	74.70	4	N
4	Bos taurus	74.70	2	growth associated protein 43
5	Macaca mulatta	74.70	2	PREDICTED: growth associated protein 43 isoform 2
6	Canis familiaris	74.70	1	PREDICTED: similar to Neuromodulin (Axonal membran
7	Felis catus	74.70	1	growth associated protein 43
8	synthetic construct	73.60	3	growth associated protein 43
9	Pongo pygmaeus	73.60	1	NEUM_PONPY Neuromodulin (Axonal membrane protein G
10	Homo sapiens	73.60	1	growth associated protein 43
11	Lonchura striata	67.40	1	growth-associated protein 43
12	Xenopus tropicalis	65.50	1	hypothetical protein LOC779658
13	Xenopus laevis	63.90	2	growth associated protein 43
14	Saimiri boliviensis	62.40	1	growth associated protein 43
15	Danio rerio	58.20	2	growth associated protein 43
16	Capra hircus	56.60	1	growth associated protein 43
17	Tetraodon nigroviridis	56.60	1	unnamed protein product
18	Serinus canaria	51.20	1	NEUM_SERCA Neuromodulin (Axonal membrane protein G
19	Monodelphis domestica	47.00	1	PREDICTED: similar to neuron growth-associated pro
20	Gallus gallus	45.40	1	PREDICTED: similar to growth-associated polypeptid

Top-ranked sequences

organism	matching
Rattus norvegicus	Query 1 MLCC#MRRTKQVEKNDEDQKIEQDGVKPEDKAHKA 34 \|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MLCC#MRRTKQVEKNDEDQKIEQDGVKPEDKAHKA 34
Mus musculus	Query 1 MLCC#MRRTKQVEKNDEDQKIEQDGVKPEDKAHKA 34 \|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MLCC#MRRTKQVEKNDEDQKIEQDGVKPEDKAHKA 34
N/A	Query 1 MLCC#MRRTKQVEKNDEDQKIEQDGVKPEDKAHKA 34 \|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\| Sbjct 1 MLCC#MRRTKQVEKNDEDQKIEQDGIKPEDKAHKA 34
Bos taurus	Query 1 MLCC#MRRTKQVEKNDEDQKIEQDGVKPEDKAHKA 34 \|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\| Sbjct 1 MLCC#MRRTKQVEKNDEDQKIEQDGIKPEDKAHKA 34
Macaca mulatta	Query 1 MLCC#MRRTKQVEKNDEDQKIEQDGVKPEDKAHKA 34 \|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\| Sbjct 1 MLCC#MRRTKQVEKNDEDQKIEQDGIKPEDKAHKA 34
Canis familiaris	Query 1 MLCC#MRRTKQVEKNDEDQKIEQDGVKPEDKAHKA 34 \|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\| Sbjct 1 MLCC#MRRTKQVEKNDEDQKIEQDGIKPEDKAHKA 34
Felis catus	Query 1 MLCC#MRRTKQVEKNDEDQKIEQDGVKPEDKAHKA 34 \|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\| Sbjct 1 MLCC#MRRTKQVEKNDEDQKIEQDGIKPEDKAHKA 34
synthetic construct	Query 1 MLCC#MRRTKQVEKNDEDQKIEQDGVKPEDKAHKA 34 \|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\| Sbjct 1 MLCC#MRRTKQVEKNDDDQKIEQDGIKPEDKAHKA 34
Pongo pygmaeus	Query 1 MLCC#MRRTKQVEKNDEDQKIEQDGVKPEDKAHKA 34 \|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\| Sbjct 1 MLCC#MRRTKQVEKNDDDQKIEQDGIKPEDKAHKA 34
Homo sapiens	Query 1 MLCC#MRRTKQVEKNDEDQKIEQDGVKPEDKAHKA 34 \|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\| Sbjct 1 MLCC#MRRTKQVEKNDDDQKIEQDGIKPEDKAHKA 34
Lonchura striata	Query 1 MLCC#MRRTKQVEKNDE-DQKIEQDGVKPEDKAHKA 34 \|\|\|\|#\|\|\|\|\|\|\|\|\|\|++ \|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\| Sbjct 1 MLCC#MRRTKQVEKNEDGDQKIEQDGIKPEDKAHKA 35
Xenopus tropicalis	Query 1 MLCC#MRRTKQVEKN-DEDQKIEQDGVKPEDKAHKA 34 \|\|\|\|#\|\|\|\|\|\|\|\|\|\| \| \|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\| Sbjct 1 MLCC#MRRTKQVEKNEDADQKIEQDGNKPEDKAHKA 35
Xenopus laevis	Query 1 MLCC#MRRTKQVEKNDE-DQKIEQDGVKPEDKAHKA 34 \|\|\|\|#\|\|\|\|\|\|\|\|\|\|++ \|\|\|\|+\|\|\| \|\|\|\|\|\|\|\|\| Sbjct 1 MLCC#MRRTKQVEKNEDGDQKIDQDGNKPEDKAHKA 35
Saimiri boliviensis	Query 6 RRTKQVEKNDEDQKIEQDGVKPEDKAHKA 34 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\| Sbjct 1 RRTKQVEKNDEDQKIEQDGIKPEDKAHKA 29
Danio rerio	Query 1 MLCC#MRRTKQVEKNDE-DQKIEQDGVKPEDKAHKA 34 \|\|\|\|#+\|\|\|\| \|\|\|\|+\| \|\|+\|+\|\|\|+\|\|\|+ \|\|\|\| Sbjct 1 MLCC#IRRTKPVEKNEEADQEIKQDGIKPEENAHKA 35
Capra hircus	Query 9 KQVEKNDEDQKIEQDGVKPEDKAHKA 34 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\| Sbjct 1 KQVEKNDEDQKIEQDGIKPEDKAHKA 26
Tetraodon nigroviridis	Query 1 MLCC#MRRTKQVEKNDE-DQKIEQDGV--KPEDKAHKA 34 \|\|\|\|#+\|\|\|\| \|\|\|\|+\| +\|\|+\|\|\|\| \|\|\|\|\|\|\|\|\| Sbjct 1 MLCC#IRRTKPVEKNEEAEQKVEQDGTTNKPEDKAHKA 37
Serinus canaria	Query 8 TKQVEKNDE-DQKIEQDGVKPEDKAHKA 34 \|\|\|\|\|\|\|++ \|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\| Sbjct 1 TKQVEKNEDGDQKIEQDGIKPEDKAHKA 28
Monodelphis domestica	Query 11 VEKNDE-DQKIEQDGVKPEDKAHKA 34 \|\|\|\|\|+ \|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\| Sbjct 21 VEKNDDADQKIEQDGIKPEDKAHKA 45
Gallus gallus	Query 11 VEKNDE-DQKIEQDGVKPEDKAHKA 34 \|\|\|\|++ \|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\| Sbjct 204 VEKNEDGDQKIEQDGIKPEDKAHKA 228

* References

[PubMed ID: 19363153] Thirumangalathu S, Harlow DE, Driskell AL, Krimm RF, Barlow LA, Fate mapping of mammalian embryonic taste bud progenitors. Development. 2009 May;136(9):1519-28.

» More (9) « Hide Below