CaMPDB :: Calpastatin

CT0083 : calpastatin [Mus musculus]

* Basic Information

Organism	Mus musculus (house mouse)
Protein Names	calpastatin; calpastatin type III; Putative uncharacterized protein
Gene Names	Cast; calpastatin
Gene Locus	13; chromosome 13
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_033947	NM_009817	12380	Q8CE80	N/A	N/A	N/A	mmu:12380

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 754 aa

Average Mass: 81.441 kDa

Monoisotopic Mass: 81.392 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Calpain_inhib 1.	143	271	116.6	8.3e-32
Calpain_inhib 2.	279	404	199.2	1.1e-56
Calpain_inhib 3.	415	545	182.4	1.3e-51
Calpain_inhib 4.	556	682	212.8	9.1e-61

3. Sequence Information

Fasta Sequence: CT0083.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 18258859] Letavernier E, Perez J, Bellocq A, Mesnard L, de Castro Keller A, Haymann JP, Baud L, Targeting the calpain/calpastatin system as a new strategy to prevent cardiovascular remodeling in angiotensin II-induced hypertension. Circ Res. 2008 Mar 28;102(6):720-8. Epub 2008 Feb 7.

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[PubMed ID: 17513017] ... Vaisid T, Kosower NS, Katzav A, Chapman J, Barnoy S, Calpastatin levels affect calpain activation and calpain proteolytic activity in APP transgenic mouse model of Alzheimer's disease. Neurochem Int. 2007 Nov-Dec;51(6-7):391-7. Epub 2007 Apr 19.

[PubMed ID: 17853947] ... Groshong JS, Spencer MJ, Bhattacharyya BJ, Kudryashova E, Vohra BP, Zayas R, Wollmann RL, Miller RJ, Gomez CM, Calpain activation impairs neuromuscular transmission in a mouse model of the slow-channel myasthenic syndrome. J Clin Invest. 2007 Oct;117(10):2903-12.

[PubMed ID: 17640526] ... Chen F, Qian L, Yang ZH, Huang Y, Ngo ST, Ruan NJ, Wang J, Schneider C, Noakes PG, Ding YQ, Mei L, Luo ZG, Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction. Neuron. 2007 Jul 19;55(2):247-60.

[PubMed ID: 16927317] ... Hood JL, Brooks WH, Roszman TL, Subcellular mobility of the calpain/calpastatin network: an organelle transient. Bioessays. 2006 Aug;28(8):850-9.

[PubMed ID: 11090425] ... Li S, Goldberg E, A novel N-terminal domain directs membrane localization of mouse testis-specific calpastatin. Biol Reprod. 2000 Dec;63(6):1594-600.

[PubMed ID: 10876161] ... Takano J, Watanabe M, Hitomi K, Maki M, Four types of calpastatin isoforms with distinct amino-terminal sequences are specified by alternative first exons and differentially expressed in mouse tissues. J Biochem. 2000 Jul;128(1):83-92.

[PubMed ID: 10403772] ... Takano J, Kawamura T, Murase M, Hitomi K, Maki M, Structure of mouse calpastatin isoforms: implications of species-common and species-specific alternative splicing. Biochem Biophys Res Commun. 1999 Jul 5;260(2):339-45.

[PubMed ID: 9473662] ... Li J, Nixon R, Messer A, Berman S, Bursztajn S, Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord. Brain Res Mol Brain Res. 1998 Jan;53(1-2):174-86.

[PubMed ID: 1730065] ... Lee WJ, Hatanaka M, Maki M, Multiple forms of rat calpastatin cDNA in the coding region of functionally unknown amino-terminal domain. Biochim Biophys Acta. 1992 Jan 6;1129(2):251-3.