CT0098 : calpastatin isoform l [Homo sapiens]
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | calpastatin isoform l; calpain inhibitor; sperm BS-17 component; heart-type calpastatin; Calpastatin; Calpain inhibitor; Sperm BS-17 component |
| Gene Names | CAST; calpastatin |
| Gene Locus | 5q15; chromosome 5 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_001035911 | NM_001042446 | 831 | P20810 | 114090 | 1515 | N/A | hsa:831 |
* Information From OMIM
Text: Calpastatin is the natural inhibitor of calpain (OMIM:114170). In erythrocytes of patients with essential hypertension (OMIM:145500), the level of calpastatin activity has been found to be significantly lower than in the red cells of normotensive subjects. Pontremoli et al. (1988) demonstrated by Western blot analysis that the decreased inhibitor activity is the result of a decrease in the amount of the inhibitor protein. Calpastatin isolated and purified from erythrocytes of normotensive and hypertensive patients had identical specific activities. Pontremoli et al. (1988) also presented evidence indicating that the decreased level of calpastatin cannot be ascribed to accelerated decay during the red cell life span. Using a cDNA probe encoding the 5-prime terminal region of CAST for spot-blot analysis of sorted chromosomes and chromosomal in situ hybridization, Inazawa et al. (1990) assigned the CAST gene to 5q14-q22. Inazawa et al. (1991) mapped CAST to 5q15-q21 by 2 methods of in situ hybridization and confirmed the results by spot-blot analysis of sorted chromosomes. Mimori et al. (1995) demonstrated that anti-calpastatin autoantibodies are present in as many as 57% of rheumatoid arthritis patients and concluded that they may participate in pathogenic mechanisms of this and other rheumatic diseases which showed a lower frequency.
* Structure Information
1. Primary Information
Length: 654 aa
Average Mass: 70.626 kDa
Monoisotopic Mass: 70.583 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Calpain_inhib 1. | 58 | 177 | 148.8 | 1.7e-41 |
| Calpain_inhib 2. | 178 | 304 | 195.4 | 1.6e-55 |
| Calpain_inhib 3. | 315 | 447 | 220.8 | 3.5e-63 |
| Calpain_inhib 4. | 458 | 584 | 227.1 | 4.4e-65 |
3. Sequence Information
Fasta Sequence: CT0098.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* References
[PubMed ID: 18809371] Stifanese R, Averna M, De Tullio R, Salamino F, Cantoni C, Mingari MC, Prato C, Pontremoli S, Melloni E, Role of the calpain-calpastatin system in the density-dependent growth arrest. Arch Biochem Biophys. 2008 Nov 15;479(2):145-52. Epub 2008 Sep 13.