CaMPDB :: Calpastatin

CT0109 : calpastatin isoform a [Rattus norvegicus]

* Basic Information

Organism	Rattus norvegicus (Norway rat)
Protein Names	calpastatin isoform a; Calpastatin (probably multiple splicing products); Calpastatin; Calpain inhibitor
Gene Names	Cast; calpastatin
Gene Locus	2q11; chromosome 2
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_445747	NM_053295	25403	Q5BK19	N/A	N/A	N/A	rno:25403

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 713 aa

Average Mass: 77.297 kDa

Monoisotopic Mass: 77.250 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Calpain_inhib 1.	127	262	97.3	5.1e-26
Calpain_inhib 2.	270	395	212.6	1e-60
Calpain_inhib 3.	406	506	146.4	8.8e-41
Calpain_inhib 4.	517	643	216.1	9.2e-62

3. Sequence Information

Fasta Sequence: CT0109.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 19020623] Hanna RA, Campbell RL, Davies PL, Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin. Nature. 2008 Nov 20;456(7220):409-12.

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[PubMed ID: 19020622] ... Moldoveanu T, Gehring K, Green DR, Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. Nature. 2008 Nov 20;456(7220):404-8.

[PubMed ID: 18809371] ... Stifanese R, Averna M, De Tullio R, Salamino F, Cantoni C, Mingari MC, Prato C, Pontremoli S, Melloni E, Role of the calpain-calpastatin system in the density-dependent growth arrest. Arch Biochem Biophys. 2008 Nov 15;479(2):145-52. Epub 2008 Sep 13.

[PubMed ID: 18544539] ... Niapour M, Yu Y, Berger SA, Regulation of calpain activity by c-Myc through calpastatin and promotion of transformation in c-Myc-negative cells by calpastatin suppression. J Biol Chem. 2008 Aug 1;283(31):21371-81. Epub 2008 Jun 10.

[PubMed ID: 18599308] ... Vilagi I, Kiss DS, Farkas A, Borbely S, Tarnok K, Halasy K, Banoczi Z, Hudecz F, Friedrich P, Synthetic calpain activator boosts neuronal excitability without extra Ca2+. Mol Cell Neurosci. 2008 Aug;38(4):629-36. Epub 2008 May 27.

[PubMed ID: 15132950] ... Weber H, Jonas L, Huhns S, Schuff-Werner P, Dysregulation of the calpain-calpastatin system plays a role in the development of cerulein-induced acute pancreatitis in the rat. Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G932-41.

[PubMed ID: 12832042] ... Barnoy S, Kosower NS, Caspase-1-induced calpastatin degradation in myoblast differentiation and fusion: cross-talk between the caspase and calpain systems. FEBS Lett. 2003 Jul 10;546(2-3):213-7.

[PubMed ID: 9475181] ... De Tullio R, Sparatore B, Salamino F, Melloni E, Pontremoli S, Rat brain contains multiple mRNAs for calpastatin. FEBS Lett. 1998 Jan 23;422(1):113-7.

[PubMed ID: 1730065] ... Lee WJ, Hatanaka M, Maki M, Multiple forms of rat calpastatin cDNA in the coding region of functionally unknown amino-terminal domain. Biochim Biophys Acta. 1992 Jan 6;1129(2):251-3.

[PubMed ID: 2015306] ... Ishida S, Emori Y, Suzuki K, Rat calpastatin has diverged primary sequence from other mammalian calpastatins but retains functionally important sequences. Biochim Biophys Acta. 1991 Mar 26;1088(3):436-8.