CaMPDB :: Calpastatin

CT0115 : calpastatin isoform I [Bos taurus]

* Basic Information

Organism	Bos taurus (cattle)
Protein Names	calpastatin isoform I; calpastatin type I; calpastatin type II; calpastatin type III; calpain inhibitor; Calpastatin type I
Gene Names	CAST; calpastatin
Gene Locus	7; chromosome 7
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_001025489	NM_001030318	281039	Q52ZG6	N/A	N/A	N/A	bta:281039

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 799 aa

Average Mass: 85.512 kDa

Monoisotopic Mass: 85.460 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Asr 1.	19	39	1.0	1.3e
Asr 2.	106	125	7.2	8
Calpain_inhib 1.	180	307	188.2	2.2e-53
Calpain_inhib 2.	315	442	196.9	5.5e-56
Calpain_inhib 3.	453	585	218.8	1.4e-62
Calpain_inhib 4.	596	723	224.9	2e-64

3. Sequence Information

Fasta Sequence: CT0115.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 17211517] Juszczuk-Kubiak E, Wyszynska-Koko J, Wicinska K, Rosochacki S, A novel polymorphisms in intron 12 of the bovine calpastatin gene. Mol Biol Rep. 2008 Mar;35(1):29-35. Epub 2007 Jan 9.

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[PubMed ID: 18082616] ... Kar P, Chakraborti T, Samanta K, Chakraborti S, Submitochondrial localization of associated mu-calpain and calpastatin. Arch Biochem Biophys. 2008 Feb 15;470(2):176-86. Epub 2007 Dec 5.

[PubMed ID: 17868638] ... Kar P, Chakraborti T, Roy S, Choudhury R, Chakraborti S, Identification of calpastatin and mu-calpain and studies of their association in pulmonary smooth muscle mitochondria. Arch Biochem Biophys. 2007 Oct 15;466(2):290-9. Epub 2007 Aug 7.

[PubMed ID: 16734705] ... Garcia MD, Michal JJ, Gaskins CT, Reeves JJ, Ott TL, Liu Y, Jiang Z, Significant association of the calpastatin gene with fertility and longevity in dairy cattle. Anim Genet. 2006 Jun;37(3):304-5.

[PubMed ID: 16424255] ... Schenkel FS, Miller SP, Jiang Z, Mandell IB, Ye X, Li H, Wilton JW, Association of a single nucleotide polymorphism in the calpastatin gene with carcass and meat quality traits of beef cattle. J Anim Sci. 2006 Feb;84(2):291-9.

[PubMed ID: 15290990] ... Cummins KA, Lonergan SM, Huff-Lonergan E, Short commuunication: Effect of dietary protein depletion and repletion on skeletal muscle calpastatin during early lactation. J Dairy Sci. 2004 May;87(5):1428-31.

[PubMed ID: 9417129] ... Cong M, Thompson VF, Goll DE, Antin PB, The bovine calpastatin gene promoter and a new N-terminal region of the protein are targets for cAMP-dependent protein kinase activity. J Biol Chem. 1998 Jan 2;273(1):660-6.

[PubMed ID: 8181976] ... Killefer J, Koohmaraie M, Bovine skeletal muscle calpastatin: cloning, sequence analysis, and steady-state mRNA expression. J Anim Sci. 1994 Mar;72(3):606-14.

[PubMed ID: 1355730] ... Parr T, Bardsley RG, Gilmour RS, Buttery PJ, Changes in calpain and calpastatin mRNA induced by beta-adrenergic stimulation of bovine skeletal muscle. Eur J Biochem. 1992 Sep 1;208(2):333-9.

[PubMed ID: 2804140] ... Mellgren RL, Lane RD, Mericle MT, The binding of large calpastatin to biologic membranes is mediated in part by interaction of an amino terminal region with acidic phospholipids. Biochim Biophys Acta. 1989 Nov 9;999(1):71-7.