CaMPDB :: Calpastatin

CT0186 : Chain B, Structure Of Calpain Domain 6 In Complex With Calpastatin Dic

* Basic Information

Organism	Sus scrofa (pig)
Protein Names	Calpain small subunit 1; CSS1; Calcium-dependent protease small subunit 1; Calcium-dependent protease small subunit; CDPS; Calpain regulatory subunit; Calcium-activated neutral proteinase small subunit; CANP small subunit
Gene Names	CAPN4
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
1NX0_B	N/A	N/A	P04574	N/A	N/A	N/A	ssc:397587

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 173 aa

Average Mass: 19.861 kDa

Monoisotopic Mass: 19.849 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
efhand 1.	48	76	18.4	0.03
efhand 2.	78	106	16.5	0.11
efhand 3.	143	170	8.2	2.7

3. Sequence Information

Fasta Sequence: CT0186.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1ALV (X-ray; 190 A; A/B=94-266), 1ALW (X-ray; 203 A; A/B=94-266), 1NX0 (X-ray; 230 A; A/B=94-266), 1NX1 (X-ray; 200 A; A/B=94-266), 1NX2 (X-ray; 220 A; A=94-266), 1NX3 (X-ray; 245 A; A=94-266)

* References

[PubMed ID: 12684003] Todd B, Moore D, Deivanayagam CC, Lin GD, Chattopadhyay D, Maki M, Wang KK, Narayana SV, A structural model for the inhibition of calpain by calpastatin: crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitor. J Mol Biol. 2003 Apr 18;328(1):131-46.