SB0008 : Phosphoinositide-specific phospholipase C[beta]1
[ CaMP Format ]
* Basic Information
| Organism | Bos taurus (cattle) |
| Protein Names | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [Bos taurus]; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; PLC-I; PLC-154; PLC-beta-1; phospholipase C-beta-1; phosphoinositide phospholipase C; phosphoinositide phospholipase C-beta-1; 3.1.4.11; Phosphoinositide phospholipase C-beta-1; Phospholipase C-beta-1 |
| Gene Names | PLCB1; phospholipase C, beta 1 (phosphoinositide-specific) |
| Gene Locus | 13; chromosome 13 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_777242 | NM_174817 | 287026 | P10894 | N/A | N/A | N/A | bta:287026 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 1216 aa
Average Mass: 138.713 kDa
Monoisotopic Mass: 138.628 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Domain of unknown function (DUF4510) 1. | 138 | 163 | 112.0 | 0.0 |
| Phosphoinositide-specific phospholipase C, efhand-like 1. | 224 | 314 | 1.0 | 0.0 |
| Phosphatidylinositol-specific phospholipase C, X domain 1. | 318 | 468 | 1.0 | 0.0 |
| Phosphatidylinositol-specific phospholipase C, Y domain 1. | 540 | 655 | 1.0 | 1.2 |
| Domain of unknown function (DUF4510) 2. | 707 | 753 | 41.0 | 0.0 |
| PLC-beta C terminal 1. | 816 | 840 | 3.0 | 0.7 |
| --- cleavage 880 --- | ||||
| Phosphatidylinositol-specific phospholipase C, X domain 2. | 913 | 932 | 98.0 | 0.3 |
| Phosphatidylinositol-specific phospholipase C, X domain 3. | 1047 | 1067 | 94.0 | 1.3 |
| Phosphatidylinositol-specific phospholipase C, X domain 4. | 1115 | 1142 | 95.0 | 0.5 |
3. Sequence Information
Fasta Sequence: SB0008.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites] cleaved by Calpain 2
Source Reference: [PubMed ID: 8429045] Park D, Jhon DY, Lee CW, Ryu SH, Rhee SG, Removal of the carboxyl-terminal region of phospholipase C-beta 1 by calpain abolishes activation by G alpha q. J Biol Chem. 1993 Feb 15;268(5):3710-4.
Cleavage sites (±10aa)
[Site 1] TPKPPSQALH880-SQPAPGSVKA
His880 
Ser
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Thr871 | Pro872 | Lys873 | Pro874 | Pro875 | Ser876 | Gln877 | Ala878 | Leu879 | His880 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser881 | Gln882 | Pro883 | Ala884 | Pro885 | Gly886 | Ser887 | Val888 | Lys889 | Ala890 |
Sequence conservation (by blast)
* References
[PubMed ID: 19393038] Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL, A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.