Function: Glucocorticoids are among the most potent antiinflammatory and immunosuppressive agents known. They inhibit synthesis of almost all cytokines and of several cell-surface molecules required for immune function. Scheinman et al. (1995) and Auphan et al. (1995) showed that the synthetic glucocorticoid dexamethasone induces transcription of the I-kappa-B-alpha gene, which results in an increased rate of synthesis of the inhibitor protein. The inhibitory protein traps activated NF-kappa-B in inactive cytoplasmic complexes. Because NF-kappa-B activates many immunoregulatory genes in response to proinflammatory stimuli, the inhibition of its activity can be a major component of the antiinflammatory activity of glucocorticoids.

Source Reference: [PubMed ID: 15202778] Schaecher K, Goust JM, Banik NL, The effects of calpain inhibition on IkB alpha degradation after activation of PBMCs: identification of the calpain cleavage sites. Neurochem Res. 2004 Jul;29(7):1443-51.

Summary

Top-ranked sequences

Query    21 KKERLLDDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL   80
            ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query    21 KKERLLDDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL   80

Query    21 KKERLLDDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL   80
            ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query    21 KKERLLDDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL   80

Query    21 KKERLLDDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL   80
            ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query    21 KKERLLDDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL   80

Query    21 KKERLLDDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL   80
            |||||||||||||||||||||||||||||+#|||||||| |||+|||||||||||||||||
Sbjct    21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL   80

Query    21 KKERLLDDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL   80
            |||||||||||||||||||||||||||||+#|||||||| |||+|||||||||||||||||
Sbjct    21 KKERLLDDRHDSGLDSMKDEEYEQMVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL   80

Query    21 KKERLLDDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL   80
            ||||||||||||||||||||||||+||||+#|||||||| |||+|||||||||||||||||
Sbjct   222 KKERLLDDRHDSGLDSMKDEEYEQLVKELR#EIRLEPQEAPRGAEPWKQQLTEDGDSFLHL  281

Query    21 KKERLLDDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL   80
            |||||+|||||||||||||||||||||||+#||||+||| |  +|||||||||||||||||
Sbjct    21 KKERLVDDRHDSGLDSMKDEEYEQMVKELR#EIRLQPQEAPLAAEPWKQQLTEDGDSFLHL   80

Query    21 KKERLLDDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL   80
            |||||+||||||||||||||+||||||||+#||||+||| |  +|||||||||||||||||
Sbjct    21 KKERLVDDRHDSGLDSMKDEDYEQMVKELR#EIRLQPQEAPLAAEPWKQQLTEDGDSFLHL   80

Query    27 DDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL   80
            ||||||||||||+||| |+|+||+#+|||+|+| |     | ||||||||+||||
Sbjct    31 DDRHDSGLDSMKEEEYRQLVRELE#DIRLQPREPPARPHAWAQQLTEDGDTFLHL   84

Query    27 DDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGS---EPWKQQLTEDGDSFLHL   80
            +|| ||||||+||+||  +||||+#++|+ | ||   |   |||++ +||| |+||||
Sbjct    31 EDRFDSGLDSLKDDEYGNLVKELE#DLRVAPVEVKSNSCSNEPWRKTVTEDRDTFLHL   87

Query    21 KKERLL-DDRHDSGLDSMKDEEYEQMVKELQ#EIRLE--PQEVPRGSEPWKQQLTEDGDSF   77
            +|++|| ||| ||||||+|+|||  ++ +| # +|+|  |       ||||+++ ||||+|
Sbjct    21 RKDKLLQDDRIDSGLDSLKEEEYTAIITDLS#NMRMEGPPDTSNYEPEPWKKEVNEDGDTF   80

Query    78 LHL   80
            |||
Query    78 LHL   80

Query    27 DDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRG--SEPWKQQLTEDGDSFLHL   80
            |+| ||||||+|+|||  ++ ++ # +||     |+    |||| ++ ||||| |||
Sbjct    25 DERMDSGLDSLKEEEYSAIISDIN#NLRLHVSPDPQSCDPEPWKTEVNEDGDSLLHL   80

Query    27 DDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL   80
            |+| ||||||+|++     +  |+#| |+     |   ||||++||||||++|||
Sbjct    31 DERLDSGLDSLKEDN----LPSLE#ECRITDFVGPT-DEPWKKELTEDGDTYLHL   79

Query    27 DDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEPWKQQLTEDGDSFLHL   80
            |+| ||||||+|++     +  |+#| |+     |   ||||++||||||++|||
Sbjct    31 DERLDSGLDSLKEDN----LPSLE#ECRITDFVGPT-DEPWKKELTEDGDTYLHL   79

Query    21 KKERLLDDRHDSGLDSMKDEEYEQMVKELQ#EIRLEPQEVPRGSEP--------WKQQLTE   72
            |  +  |+| ||||||+++|||        # +|+| +  |   ||        || |+||
Sbjct    11 KPAQATDERLDSGLDSLREEEY--------#RLRVECEPPPHKPEPAAAAELPEWKTQVTE   62

Query    73 DGDSFLHL   80
            |||+ |||
Sbjct    63 DGDTLLHL   70

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[PubMed ID: 8601309] ... Chen ZJ, Parent L, Maniatis T, Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. Cell. 1996 Mar 22;84(6):853-62.

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[PubMed ID: 3140380] ... Baeuerle PA, Baltimore D, I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science. 1988 Oct 28;242(4878):540-6.