logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0012 : Histone H2B type 1

[ CaMP Format ]

* Basic Information

OrganismBos taurus (cattle)
Protein NamesH2B histone family, member L [Bos taurus]; H2B histone family, member L; Histone H2B type 1
Gene NamesHIST1H2BC
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
ABM06136 N/A N/A P62808 N/A N/A N/A bta:787465

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 126 aa

Average Mass: 13.906 kDa

Monoisotopic Mass: 13.898 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 6 ---
Histone-like transcription factor (CBF/NF-Y) and archaeal histone 1. 162742.00.4
--- cleavage 20 (inside Histone-like transcription factor (CBF/NF-Y) and archaeal histone 16..27) ---
--- cleavage 40 ---
--- cleavage 42 ---
Transcription initiation factor TFIID subunit A 1. 45978.00.0
--- cleavage 46 (inside Transcription initiation factor TFIID subunit A 45..97) ---
--- cleavage 53 (inside Transcription initiation factor TFIID subunit A 45..97) ---
--- cleavage 64 (inside Transcription initiation factor TFIID subunit A 45..97) ---
--- cleavage 81 (inside Transcription initiation factor TFIID subunit A 45..97) ---
--- cleavage 96 (inside Transcription initiation factor TFIID subunit A 45..97) ---

3. Sequence Information

Fasta Sequence: SB0012.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

14 [sites]

Source Reference: [PubMed ID: 3038857] Sakai K, Akanuma H, Imahori K, Kawashima S, A unique specificity of a calcium activated neutral protease indicated in histone hydrolysis. J Biochem. 1987 Apr;101(4):911-8.

Cleavage sites (±10aa)

[Site 1] MPEPAK6-SAPAPKKGSK

Lys6 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
----Met1Pro2Glu3Pro4Ala5Lys6
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser7Ala8Pro9Ala10Pro11Lys12Lys13Gly14Ser15Lys16

Sequence conservation (by blast)

[Site 2] PKKGSKKAVT20-KAQKKDGKKR

Thr20 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro11Lys12Lys13Gly14Ser15Lys16Lys17Ala18Val19Thr20
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys21Ala22Gln23Lys24Lys25Asp26Gly27Lys28Lys29Arg30

Sequence conservation (by blast)

[Site 3] KRSRKESYSV40-YVYKVLKQVH

Val40 Tyr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys31Arg32Ser33Arg34Lys35Glu36Ser37Tyr38Ser39Val40
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Tyr41Val42Tyr43Lys44Val45Leu46Lys47Gln48Val49His50

Sequence conservation (by blast)

[Site 4] SRKESYSVYV42-YKVLKQVHPD

Val42 Tyr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ser33Arg34Lys35Glu36Ser37Tyr38Ser39Val40Tyr41Val42
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Tyr43Lys44Val45Leu46Lys47Gln48Val49His50Pro51Asp52

Sequence conservation (by blast)

[Site 5] SYSVYVYKVL46-KQVHPDTGIS

Leu46 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ser37Tyr38Ser39Val40Tyr41Val42Tyr43Lys44Val45Leu46
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys47Gln48Val49His50Pro51Asp52Thr53Gly54Ile55Ser56

Sequence conservation (by blast)

[Site 6] KVLKQVHPDT53-GISSKAMGIM

Thr53 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys44Val45Leu46Lys47Gln48Val49His50Pro51Asp52Thr53
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gly54Ile55Ser56Ser57Lys58Ala59Met60Gly61Ile62Met63

Sequence conservation (by blast)

[Site 7] ISSKAMGIMN64-SFVNDIFERI

Asn64 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ile55Ser56Ser57Lys58Ala59Met60Gly61Ile62Met63Asn64
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser65Phe66Val67Asn68Asp69Ile70Phe71Glu72Arg73Ile74

Sequence conservation (by blast)

[Site 8] ERIAGEASRL81-AHYNKRSTIT

Leu81 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu72Arg73Ile74Ala75Gly76Glu77Ala78Ser79Arg80Leu81
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala82His83Tyr84Asn85Lys86Arg87Ser88Thr89Ile90Thr91

Sequence conservation (by blast)

[Site 9] RSTITSREIQ96-TAVRLLLPGE

Gln96 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg87Ser88Thr89Ile90Thr91Ser92Arg93Glu94Ile95Gln96
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Thr97Ala98Val99Arg100Leu101Leu102Leu103Pro104Gly105Glu106

Sequence conservation (by blast)

[Site 10] SREIQTAVRL101-LLPGELAKHA

Leu101 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ser92Arg93Glu94Ile95Gln96Thr97Ala98Val99Arg100Leu101
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu102Leu103Pro104Gly105Glu106Leu107Ala108Lys109His110Ala111

Sequence conservation (by blast)

[Site 11] QTAVRLLLPG105-ELAKHAVSEG

Gly105 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gln96Thr97Ala98Val99Arg100Leu101Leu102Leu103Pro104Gly105
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu106Leu107Ala108Lys109His110Ala111Val112Ser113Glu114Gly115

Sequence conservation (by blast)

[Site 12] TAVRLLLPGE106-LAKHAVSEGT

Glu106 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Thr97Ala98Val99Arg100Leu101Leu102Leu103Pro104Gly105Glu106
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu107Ala108Lys109His110Ala111Val112Ser113Glu114Gly115Thr116

Sequence conservation (by blast)

[Site 13] AVRLLLPGEL107-AKHAVSEGTK

Leu107 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala98Val99Arg100Leu101Leu102Leu103Pro104Gly105Glu106Leu107
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala108Lys109His110Ala111Val112Ser113Glu114Gly115Thr116Lys117

Sequence conservation (by blast)

[Site 14] LAKHAVSEGT116-KAVTKYTSSK

Thr116 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Leu107Ala108Lys109His110Ala111Val112Ser113Glu114Gly115Thr116
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys117Ala118Val119Thr120Lys121Tyr122Thr123Ser124Ser125Lys126

Sequence conservation (by blast)

* References

[PubMed ID: 12140684] Sonstegard TS, Capuco AV, White J, Van Tassell CP, Connor EE, Cho J, Sultana R, Shade L, Wray JE, Wells KD, Quackenbush J, Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Mamm Genome. 2002 Jul;13(7):373-9.

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