SB0015 : Ryanodine receptor
[ CaMP Format ]
* Basic Information
| Organism | Oryctolagus cuniculus (rabbit) |
| Protein Names | ryanodine receptor [Oryctolagus cuniculus]; ryanodine receptor; Ryanodine receptor 1; RYR-1; RyR1; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor |
| Gene Names | RYR1 |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| CAA33279 | N/A | N/A | P11716 | N/A | N/A | N/A | ocu:100009540 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 5037 aa
Average Mass: 565.246 kDa
Monoisotopic Mass: 564.892 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| MIR domain 1. | 103 | 185 | 5.0 | 0.1 |
| Inositol 1,4,5-trisphosphate/ryanodine receptor 1. | 258 | 294 | 143.0 | 0.0 |
| Inositol 1,4,5-trisphosphate/ryanodine receptor 2. | 332 | 360 | 91.0 | 0.0 |
| RyR and IP3R Homology associated 1. | 381 | 461 | 19.0 | 0.0 |
| Replication protein C C-terminal region 1. | 467 | 519 | 90.0 | 0.0 |
| SPRY domain 1. | 661 | 795 | 1.0 | 0.0 |
| RyR domain 1. | 851 | 940 | 1.0 | 0.0 |
| RyR domain 2. | 965 | 1054 | 1.0 | 0.0 |
| SPRY domain 2. | 1087 | 1206 | 1.0 | 0.0 |
| --- cleavage 1400 --- | ||||
| SPRY domain 3. | 1433 | 1568 | 2.0 | 0.3 |
| Presenilin 1. | 1876 | 1918 | 272.0 | 6.1 |
| Domain of unknown function (DUF1840) 1. | 2036 | 2077 | 72.0 | 0.2 |
| RyR and IP3R Homology associated 2. | 2107 | 2161 | 32.0 | 0.0 |
| Domain of unknown function (DUF1840) 2. | 2373 | 2437 | 42.0 | 0.0 |
| RyR domain 3. | 2735 | 2825 | 1.0 | 0.8 |
| --- cleavage 2843 --- | ||||
| RyR domain 4. | 2855 | 2938 | 1.0 | 0.0 |
| DDHD domain 1. | 3460 | 3495 | 100.0 | 0.0 |
| RIH domain 1. | 3824 | 3895 | 28.0 | 0.3 |
| Ion transport protein 1. | 4043 | 4070 | 37.0 | 0.0 |
| EF-hand domain pair 1. | 4084 | 4133 | 1.0 | 0.1 |
| CDC45-like protein 1. | 4302 | 4337 | 382.0 | 0.1 |
| Ryanodine Receptor TM 4-6 1. | 4382 | 4670 | 2.0 | 0.0 |
| Ion transport protein 2. | 4802 | 4947 | 93.0 | 4.5 |
3. Sequence Information
Fasta Sequence: SB0015.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB: 2BCX (X-ray; 200 A; B=3614-3643), 2XOA (X-ray; 250 A; A=1-559), 3HSM (X-ray; 250 A; A/B=1-210), 3ILA (X-ray; 290 A; A/B/C/D/E/F/G/H/I=9-205), 3J8E (EM; 480 A; C/E/G/H=1-5037), 3J8H (EM; 380 A; A/C/E/G=1-5037), 3RQR (X-ray; 216 A; A=2733-2940), 4ERT (X-ray; 195 A; A=2734-2940), 4ESU (X-ray; 159 A; A=2734-2940), 4ETT (X-ray; 220 A; A=2734-2940), 4ETU (X-ray; 219 A; A=2734-2938), 4I0Y (X-ray; 280 A; A=1-536), 4I1E (X-ray; 240 A; A=1-536), 4I2S (X-ray; 250 A; A=1-536), 4I37 (X-ray; 295 A; A=1-536), 4I3N (X-ray; 295 A; A=1-536), 4I6I (X-ray; 250 A; A=1-559), 4I7I (X-ray; 290 A; A=1-536), 4I8M (X-ray; 280 A; A=1-536), 4I96 (X-ray; 273 A; A=217-536), 4P9J (X-ray; 184 A; A/B/C=1070-1246), 4UWA (EM; 610 A; A/B/C/D=1-533, A/B/C/D=649-1571, A/B/C/D=2734-2939), 4UWE (EM; 850 A; A/B/C/D=1-533, A/B/C/D=649-1571, A/B/C/D=2734-2939)
* Cleavage Information
2 [sites] cleaved by Calpain 2
Source Reference: [PubMed ID: 9312113] Wu Y, Aghdasi B, Dou SJ, Zhang JZ, Liu SQ, Hamilton SL, Functional interactions between cytoplasmic domains of the skeletal muscle Ca2+ release channel. J Biol Chem. 1997 Oct 3;272(40):25051-61.
Cleavage sites (±10aa)
[Site 1] FKAKKAAMMT1400-QPPATPALPR
Thr1400 
Gln
iTraq-117 Signal 4310.9 (
) for QPPATPALPR
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Phe1391 | Lys1392 | Ala1393 | Lys1394 | Lys1395 | Ala1396 | Ala1397 | Met1398 | Met1399 | Thr1400 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gln1401 | Pro1402 | Pro1403 | Ala1404 | Thr1405 | Pro1406 | Ala1407 | Leu1408 | Pro1409 | Arg1410 |
Sequence conservation (by blast)
[Site 2] TEKKKTRKIS2843-QTAQTYDPRE
Ser2843 Gln
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Thr2834 | Glu2835 | Lys2836 | Lys2837 | Lys2838 | Thr2839 | Arg2840 | Lys2841 | Ile2842 | Ser2843 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gln2844 | Thr2845 | Ala2846 | Gln2847 | Thr2848 | Tyr2849 | Asp2850 | Pro2851 | Arg2852 | Glu2853 |
Sequence conservation (by blast)
* References
[PubMed ID: 2725677] Takeshima H, Nishimura S, Matsumoto T, Ishida H, Kangawa K, Minamino N, Matsuo H, Ueda M, Hanaoka M, Hirose T, et al., Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor. Nature. 1989 Jun 8;339(6224):439-45.