CaMPDB :: Substrate

SB0024 : Protein tyrosine phosphatase, receptor type, N

* Basic Information

Organism	Homo sapiens (human)
Protein Names	receptor-type tyrosine-protein phosphatase-like N isoform 1 precursor [Homo sapiens]; receptor-type tyrosine-protein phosphatase-like N isoform 1 precursor; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N; islet cell antigen 2; ICA 512; PTP IA-2; Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; Islet cell autoantigen 3
Gene Names	PTPRN; ICA3, ICA512; ICA3; ICA512; protein tyrosine phosphatase, receptor type, N
Gene Locus	2q35-q36.1; chromosome 2
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_002837	NM_002846	5798	Q16849	601773	HGNC:9676	03466	hsa:5798

* Information From OMIM

Text: For general information about protein-tyrosine phosphatases (PTPases), see PTPRA (OMIM:176884).

* Structure Information

1. Primary Information

Length: 979 aa

Average Mass: 105.846 kDa

Monoisotopic Mass: 105.781 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
RESP18 domain 1.	60	155	1.0	0.8
RESP18 domain 2.	335	358	14.0	0.1
Protein-tyrosine phosphatase receptor IA-2 1.	469	557	1.0	0.0
--- cleavage 608 ---
--- cleavage 658 ---
Dual specificity phosphatase, catalytic domain 1.	892	954	64.0	0.0

3. Sequence Information

Fasta Sequence: SB0024.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 2I1Y (X-ray; 223 A; A/B=681-979), 2QT7 (X-ray; 130 A; A/B=468-558), 3N01 (X-ray; 130 A; A/B=470-558), 3N4W (X-ray; 145 A; A/B=470-558), 3NG8 (X-ray; 135 A; A/B=470-558), 3NP5 (X-ray; 180 A; A/B/C/D=470-558)

* Cleavage Information

2 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 11483505] Ort T, Voronov S, Guo J, Zawalich K, Froehner SC, Zawalich W, Solimena M, Dephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion. EMBO J. 2001 Aug 1;20(15):4013-23.

Cleavage sites (±10aa)

[Site 1] CVRQHARQQD⁶⁰⁸-KERLAALGPE

Asp⁶⁰⁸ Lys

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Cys⁵⁹⁹	Val⁶⁰⁰	Arg⁶⁰¹	Gln⁶⁰²	His⁶⁰³	Ala⁶⁰⁴	Arg⁶⁰⁵	Gln⁶⁰⁶	Gln⁶⁰⁷	Asp⁶⁰⁸

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Lys⁶⁰⁹	Glu⁶¹⁰	Arg⁶¹¹	Leu⁶¹²	Ala⁶¹³	Ala⁶¹⁴	Leu⁶¹⁵	Gly⁶¹⁶	Pro⁶¹⁷	Glu⁶¹⁸

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
LTLVALAGVAGLLVALAVALCVRQHARQQDKERLAALGPEGAHGDTTFEYQDLCRQHMAT

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	124.00	8	protein tyrosine phosphatase, receptor type, N pr
2	synthetic construct	124.00	1	Homo sapiens protein tyrosine phosphatase, recept
3	Bos taurus	122.00	1	protein tyrosine phosphatase, receptor type, N
4	Pongo pygmaeus	122.00	1	hypothetical protein
5	Canis familiaris	119.00	2	PREDICTED: similar to Receptor-type tyrosine-prot
6	Mus musculus	118.00	8	AF332083_1 protein tyrosine phosphatase receptor
7	N/A	117.00	7	PTPRN_MOUSE Receptor-type tyrosine-protein phosph
8	Rattus sp.	116.00	1	protein tyrosine phosphatase-like protein
9	Rattus norvegicus	115.00	3	protein tyrosine phosphatase, receptor type, N
10	Tetraodon nigroviridis	55.10	4	unnamed protein product
11	Danio rerio	54.70	1	PREDICTED: similar to islet cell autoantigen 512
12	Homo sapiens	50.10	2	tyrosine phosphatase IA-2beta
13	Macaca nemestrina	49.70	2	PTPR2_MACNE Receptor-type tyrosine-protein phosph
14	Schistosoma japonicum	37.70	1	AF333765_1 DAD-1-like protein
15	Callithrix jacchus	34.30	1	AF452616_1 lymphocyte antigen CD4
16	Caenorhabditis briggsae AF16	33.10	2	Hypothetical protein CBG12659
17	Saimiri sciureus	33.10	1	CD4_SAISC T-cell surface glycoprotein CD4 precurs
18	Cloning vector pMACSiBac	33.10	1	CD4-EGFP
19	Saimiri sciureus	33.10	1	AF452617_1 lymphocyte antigen CD4
20	Macaca mulatta	32.30	2	CD4 precursor
21	Drosophila melanogaster	32.30	1	CG13393 CG13393-PA
22	Macaca fuscata	32.30	1	CD4_MACFU T-cell surface glycoprotein CD4 precurs
23	Macaca fascicularis	32.30	1	CD4_MACFA T-cell surface glycoprotein CD4 precurs
24	Anopheles gambiae	32.00	1	defender against programmed cell death
25	Anopheles gambiae str. PEST	32.00	1	AGAP008491-PA
26	Pan troglodytes	31.60	1	CD4 antigen
27	Burkholderia sp. 383	31.60	1	Major facilitator superfamily, (MFS_1) family
28	Ustilago maydis 521	31.20	1	hypothetical protein UM01289.1
29	Argopecten irradians	30.80	1	defender against apopototic cell death 1
30	Chlorocebus aethiops	30.80	1	CD4

Top-ranked sequences

organism	matching
Homo sapiens	Query 579 LTLVALAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 638 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 579 LTLVALAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 638
synthetic construct	Query 579 LTLVALAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 638 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 579 LTLVALAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 638
Bos taurus	Query 579 LTLVALAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 638 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 579 LTLVALAGVAGLLVALAVALCVRQHARQRD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 638
Pongo pygmaeus	Query 579 LTLVALAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 638 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 579 LTLVALAGVAGLLVALAVALCVRQHARQRD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 638
Canis familiaris	Query 579 LTLVALAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTFEYQDLCRQHMA 637 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 676 LTLVALAGVAGLLVALAVALCVRQHARQRD#KERLAALGPEGAHGDTTFEYQDLCRQHMA 734
Mus musculus	Query 579 LTLVALAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 638 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\| \|+\|\|+\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 476 LTLVALAGVAGLLVALAVALCMRHHSRQRD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 535
N/A	Query 579 LTLVALAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 638 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\| \|+\|\|+\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 579 LTLVALAGVAGLLVALAVALCMRHHSRQRD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 638
Rattus sp.	Query 579 LTLVALAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 638 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\| \|++\|+\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 522 LTLVALAGVAGLLVALAVALCMRHHSKQRD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 581
Rattus norvegicus	Query 579 LTLVALAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 638 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\| \|++\|+\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 583 LTLVALAGVAGLLVALAVALCMRHHSKQRD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 642
Tetraodon nigroviridis	Query 579 LTLVALAGVAG-LLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTFEYQDLCRQHMA 637 +\|\|\|++\| \| \| \|\|+\|+\|\|\| \| \| + +\| # +\| \|\|\|\|\| +\| \|+\|\|+\|\|\|\|\|\|\| Sbjct 425 ITLVSMAAVGGVLLLAMAVA-CFRHYNQQVA#NGKLG-LGPEGG-AETHFDYQELCRQHMA 481 Query 638 T 638 + Sbjct 482 S 482
Danio rerio	Query 579 LTLVALAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTFEYQDLCRQHMA 637 \| \| +\| + \|\|\|\| \|+\| \|\|\| # +\| \|\|\|\| \| \| +\|\|\|\|\|\|\|\|\|\|\| Sbjct 505 LMFVGVACLGGLLVGALTIACLRTHARHLA#SGKLG-LGPE-AGNVTHYEYQDLCRQHMA 561
Homo sapiens	Query 579 LTLVALAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHG-DTTFEYQDLCRQHMA 637 \|\|\|\|+\|\| + \|+\|+\| + \|+\| ++ + #\|\|+\|+ \|\| \| \| \| \| \|\|+\|\|\|\| \|\| Sbjct 589 LTLVSLACILGVLLASGLIYCLRHSSQHRL#KEKLSGLG--GDPGADATAAYQELCRQRMA 646 Query 638 T 638 \| Query 638 T 638
Macaca nemestrina	Query 579 LTLVALAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTFEYQDLCRQHMAT 638 \|\|\|\|+\|\| + \|+\|+\| + \|+\| ++ + #\|\|+\|+ \|\| \| \| \|\|+\|\|\|\| \|\|\| Sbjct 616 LTLVSLACILGVLLASGLIYCLRHSSQHRL#KEKLSGLG-RDPGADATAAYQELCRQRMAT 674
Schistosoma japonicum	Query 584 LAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTF 626 \|+\| + + +\|+\|+\| \|+ \|+#\| \|\| \|+ \| \| Sbjct 78 LSGFISCVASFILAVCLRMHSNPQN#KNVFIPFCPESAYADFIF 120
Callithrix jacchus	Query 579 LTLVALAGVAGLLV--ALAVALCVRQHARQQD#KERLAAL 615 + \|+ \| \|\|\|\|\|\|\| \| + \|\|\|\| \|++ # \|\|++ + Sbjct 396 MALIVLGGVAGLLVFTGLGIFLCVRCRHRRRQ#AERMSQI 434
Caenorhabditis briggsae AF16	Query 584 LAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTF 626 \|+\| + + +\| \|+\| \|++#+ +++ \|\| \| \| \| Sbjct 57 LSGFISTVTSFVLASCLRMQVNQEN#RSEFSSVSPERAFADFLF 99
Saimiri sciureus	Query 579 LTLVALAGVAGLL--VALAVALCVRQHARQQD#KERLAAL 615 + \|+ \| \|\|\|\|\|\| \| + \|\|\|\| \|++ # \|\|++ + Sbjct 396 MVLIVLGGVAGLLAFTGLGIFLCVRCRHRRRQ#AERMSQI 434
Cloning vector pMACSiBac	Query 579 LTLVALAGVAGLL--VALAVALCVRQHARQQD#KERLAAL 615 + \|+ \| \|\|\|\|\|\| + \| + \|\|\| \|++ # \|\|++ + Sbjct 397 MALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ#AERMSQI 435
Saimiri sciureus	Query 579 LTLVALAGVAGLL--VALAVALCVRQHARQQD#KERLAAL 615 + \|+ \| \|\|\|\|\|\| \| + \|\|\|\| \|++ # \|\|++ + Sbjct 396 MVLIVLGGVAGLLAFTGLGIFLCVRCRHRRRQ#AERMSQI 434
Macaca mulatta	Query 579 LTLVALAGVAGLLV--ALAVALCVRQHARQQD#KERLAAL 615 + \|+ \| \|\|\|\|\|\|+ \| + \|\|\| \|++ # \|\|++ + Sbjct 397 MALIVLGGVAGLLLFTGLGIFFCVRCRHRRRQ#AERMSQI 435
Drosophila melanogaster	Query 584 LAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTF 626 \|+\| + +\|+\|+\| \| \|+#\| \| + \|\| \| \| Sbjct 56 LSGFISTVSCFVLAVCLRLQANPQN#KSVFAGISPERGFADFIF 98
Macaca fuscata	Query 579 LTLVALAGVAGLLV--ALAVALCVRQHARQQD#KERLAAL 615 + \|+ \| \|\|\|\|\|\|+ \| + \|\|\| \|++ # \|\|++ + Sbjct 397 MALIVLGGVAGLLLFTGLGIFFCVRCRHRRRQ#AERMSQI 435
Macaca fascicularis	Query 579 LTLVALAGVAGLLV--ALAVALCVRQHARQQD#KERLAAL 615 + \|+ \| \|\|\|\|\|\|+ \| + \|\|\| \|++ # \|\|++ + Sbjct 397 MALIVLGGVAGLLLFTGLGIFFCVRCRHRRRQ#AERMSQI 435
Anopheles gambiae	Query 584 LAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTF 626 \|\|\| + + +\|+\| + \|+#\|\|+ + \|\| \| \| Sbjct 56 LAGFISTVSCFVLGVCLRLQSNPQN#KEQFFGISPERGFADFVF 98
Anopheles gambiae str. PEST	Query 584 LAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTF 626 \|\|\| + + +\|+\| + \|+#\|\|+ + \|\| \| \| Sbjct 56 LAGFISTVSCFVLGVCLRLQSNPQN#KEQFLGISPERGFADFVF 98
Pan troglodytes	Query 579 LTLVALAGVAGLL--VALAVALCVRQHARQQD#KERLAAL 615 + \|+ \| \|\|\|\|\|\| + \| + \|\|\| \|++ # +\|++ + Sbjct 397 MALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQ#AQRMSQI 435
Burkholderia sp. 383	Query 584 LAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTFEYQD 630 \| \|+ \|\|\|\|\| \|\|\| \|\|+ +\|\|\| #+ \| \|\| \|+ ++ Sbjct 229 LVGLPGLLVAAIVALTVREPSRQQV#R--------HSAAGDRTYSLRE 267
Ustilago maydis 521	Query 583 ALAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTT 625 +\| \|\| \|\|+\| + + +\| \|+\| +\|#+ \|\|\| \| \| Sbjct 499 SLGGVGGLIVLILLMVCCRRHCAAED#RHF------RGAHPDDT 535
Argopecten irradians	Query 584 LAGVAGLLVALAVALCVRQHARQQD#KERLAALGPEGAHGDTTF 626 \|+\| + + + +\|+\| \|+#\| +\|\|\| \| \| \| Sbjct 57 LSGFISSVGSFVLGVCLRLQVNPQN#KHDFTGIGPERAFADFIF 99
Chlorocebus aethiops	Query 579 LTLVALAGVAGLLV--ALAVALCVRQHARQQD#KERLAAL 615 + \|+ \| \|\|\|\|\|\|+ \| + \|\|\| \|++ # +\|++ + Sbjct 397 MALIVLGGVAGLLLFTGLGIFFCVRCRHRRRQ#AQRMSQI 435

[Site 2] PEPSRVSSVS⁶⁵⁸-SQFSDAAQAS

Ser⁶⁵⁸ Ser

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Pro⁶⁴⁹	Glu⁶⁵⁰	Pro⁶⁵¹	Ser⁶⁵²	Arg⁶⁵³	Val⁶⁵⁴	Ser⁶⁵⁵	Ser⁶⁵⁶	Val⁶⁵⁷	Ser⁶⁵⁸

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ser⁶⁵⁹	Gln⁶⁶⁰	Phe⁶⁶¹	Ser⁶⁶²	Asp⁶⁶³	Ala⁶⁶⁴	Ala⁶⁶⁵	Gln⁶⁶⁶	Ala⁶⁶⁷	Ser⁶⁶⁸

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
QDLCRQHMATKSLFNRAEGPPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMD

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	125.00	7	Islet Cell Antigen 512
2	synthetic construct	125.00	1	Homo sapiens protein tyrosine phosphatase, recept
3	Bos taurus	124.00	1	protein tyrosine phosphatase, receptor type, N
4	Pongo pygmaeus	124.00	1	hypothetical protein
5	Rattus norvegicus	122.00	3	brain-enriched membrane-associated protein tyrosi
6	Mus musculus	121.00	8	PTP 35 protein
7	N/A	121.00	4	PTPRN_RAT Receptor-type tyrosine-protein phosphat
8	Rattus sp.	121.00	1	protein tyrosine phosphatase-like protein
9	Canis familiaris	119.00	2	PREDICTED: similar to Receptor-type tyrosine-prot
10	Tetraodon nigroviridis	65.10	5	unnamed protein product
11	Danio rerio	60.10	1	PREDICTED: similar to islet cell autoantigen 512
12	Macaca nemestrina	50.10	1	PTPR2_MACNE Receptor-type tyrosine-protein phosph
13	Homo sapiens	49.30	2	tyrosine phosphatase IA-2beta
14	Apis mellifera	42.70	1	PREDICTED: similar to ia2 CG31795-PA, isoform A i
15	Arabidopsis thaliana	33.50	1	AF412083_1 AT4g35240/F23E12_200
16	Arabidopsis thaliana	30.80	1	unknown protein

Top-ranked sequences

organism	matching
Homo sapiens	Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688
synthetic construct	Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688
Bos taurus	Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688
Pongo pygmaeus	Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688
Rattus norvegicus	Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 238 QDLCRQHMATKSLFNRAEGQPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 297
Mus musculus	Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 646 QDLCRQHMATKSLFNRAEGQPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 705
N/A	Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 633 QDLCRQHMATKSLFNRAEGQPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 692
Rattus sp.	Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 572 QDLCRQHMATKSLFNRAEGQPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 631
Canis familiaris	Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688 \|\|\|\|\|\|\|\|\| \|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 726 QDLCRQHMAAKSLFSRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 785
Tetraodon nigroviridis	Query 629 QDLCRQHMATKSLFNRAEGPP-----------------------EPSRVSSVS#SQFSDAA 665 \|\|\|\|\|\|\|\|\|+\| \| \| \| \|\|\| \|\|\|#\|\|\|\|\| \| Sbjct 53 QDLCRQHMASKGAFGRLEAAALSAVGGASGAAGAGGGGASVGGGVDSRVGSVS#SQFSDGA 112 Query 666 QASPSSHSSTPSWCEEPAQANMD 688 \| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 113 QPSPSSHSSTPSWCEEPAQANMD 135
Danio rerio	Query 629 QDLCRQHMATKSLFNRAE-------------------GPPEPSRVSSVS#SQFSDAAQASP 669 \|\|\|\|\|\|\|\|\| \|\| \| + \| + \|\|\|\|\|\|\|#\|\|\|\|\|\| \| \|\| Sbjct 553 QDLCRQHMAAKSSLGRQDCGVGAAGGAGPGAVGGGGGGGTDTSRVSSVS#SQFSDAPQPSP 612 Query 670 SSHSSTPSWCEEPAQANMD 688 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\| Sbjct 613 SSHSSTPSWCEEPAQSNMD 631
Macaca nemestrina	Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688 \|+\|\|\|\| \|\|\|+ +\| \|\|\| \|\|+\|\|\|\|#\|\|\|\|\| \|\|\|+ \|\| \|\| \|\|\| \|+\|\|\| Sbjct 665 QELCRQRMATRPP-DRPEGP-HTSRISSVS#SQFSDGPMPSPSARSSASSWSEEPVQSNMD 722
Homo sapiens	Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688 \|+\|\|\|\| \|\|\|+ +\| \|\|\| \|\|+\|\|\|\|#\|\|\|\|\| \|\|\|+ \|\| \|\| \|\|\| \|+\|\|\| Sbjct 638 QELCRQRMATRPP-DRPEGP-HTSRISSVS#SQFSDGPIPSPSARSSASSWSEEPVQSNMD 695
Apis mellifera	Query 629 QDLCRQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANMD 688 \|\|\|\|\| \| \| ++ \| \| \|++\|+\|# + + + \|\|+ \|\|\| \|\| \|\|\| +\|\|\| Sbjct 542 QDLCRARMHAKQTTDKPESP----RITSLS#RE--NESNNLPSNRSSTSSWGEEPTLSNMD 595
Arabidopsis thaliana	Query 633 RQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQ 684 \|+++++\| \|+ \|\| \| \|\| \|\|\| #\| \| \|+\| \|\| + \|++ + \|+ Sbjct 11 RKNVSSKKLY---EGTPSPSVVSSAQ#SSTSKKAKAEASSSVTAPTYADIEAE 59
Arabidopsis thaliana	Query 633 RQHMATKSLFNRAEGPPEPSRVSSVS#SQFSDAAQASPSSHSSTPSWCEEPAQANM 687 \|+++++\| \|+ \|\| \| \|\| \|\|\| #\| \| \|+\| \|\| + \|++ + \|+ + Sbjct 345 RKNVSSKKLY---EGTPSPSVVSSAQ#SSTSKKAKAEASSSVTAPTYADIEAELAL 396

* References

[PubMed ID: 23396399] Long AE, Gillespie KM, Aitken RJ, Goode JC, Bingley PJ, Williams AJ, Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes. Diabetes. 2013 Jun;62(6):2067-71. doi: 10.2337/db12-1468. Epub 2013 Feb 8.

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[PubMed ID: 23110943] ... Krause S, Chmiel R, Bonifacio E, Scholz M, Powell M, Furmaniak J, Rees Smith B, Ziegler AG, Achenbach P, IA-2 autoantibody affinity in children at risk for type 1 diabetes. Clin Immunol. 2012 Dec;145(3):224-9. doi: 10.1016/j.clim.2012.09.010. Epub 2012

[PubMed ID: 11043403] ... Ort T, Maksimova E, Dirkx R, Kachinsky AM, Berghs S, Froehner SC, Solimena M, The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells. Eur J Cell Biol. 2000 Sep;79(9):621-30.

[PubMed ID: 9828138] ... Xie J, Zhang B, Lan MS, Notkins AL, Genomic structure and promoter sequence of the insulin-dependent diabetes mellitus autoantigen, IA-2 (PTPRN). Genomics. 1998 Dec 1;54(2):338-43.

[PubMed ID: 8798755] ... Cui L, Yu WP, DeAizpurua HJ, Schmidli RS, Pallen CJ, Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes. J Biol Chem. 1996 Oct 4;271(40):24817-23.

[PubMed ID: 8641276] ... Solimena M, Dirkx R Jr, Hermel JM, Pleasic-Williams S, Shapiro JA, Caron L, Rabin DU, ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. EMBO J. 1996 May 1;15(9):2102-14.

[PubMed ID: 8646884] ... van den Maagdenberg AM, Olde Weghuis D, Rijss J, van de Wetering RA, Wieringa B, Geurts van Kessel A, Hendriks WJ, Assignment of the human gene for receptor-type protein tyrosine phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and identification of an intragenic genetic marker. Cytogenet Cell Genet. 1996;73(1-2):145-8.

[PubMed ID: 8024693] ... Lan MS, Lu J, Goto Y, Notkins AL, Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol. 1994 May;13(5):505-14.

[PubMed ID: 8144912] ... Rabin DU, Pleasic SM, Shapiro JA, Yoo-Warren H, Oles J, Hicks JM, Goldstein DE, Rae PM, Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunol. 1994 Mar 15;152(6):3183-8.